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A more affordable
EpiPen® alternative

Epipen Alternative, Epinephrine OTC, CVS Pharmacy
Epipen Alternative, Epinephrine OTC, CVS Pharmacy
Epipen Alternative, Epinephrine OTC, CVS Pharmacy

The generic epinephrine auto-injector is easy to use1 and contains the same active medicine as EpiPen®. Here's a video on how to use the epinephrine auto-injector, provided by Lineage Therapeutics, Inc.

Lowest Cash Price Epinephrine Auto-Injector Now Available at CVS Pharmacy®

Patients with life-threatening allergies need immediate access to injectable epinephrine. But over time, the brand-name epinephrine auto-injector pens that make it easy to quickly and safely administer the medication have become increasingly expensive.

We recognized the urgent need for a less-expensive epinephrine auto-injector, and are proud to offer a low-cost option at all CVS Pharmacy locations. Patients can now purchase the authorized generic for Adrenaclick® at a cash price of $109.99 for a two-pack – the lowest cash price in the market. This authorized generic is a Food and Drug Administration (FDA)-approved device with the same active ingredient as other epinephrine auto-injector devices.

Frequently asked questions

Are the EpiPen® auto-injector and the authorized generic for Adrenaclick® approved by the FDA?

Both the EpiPen auto-injectors and the authorized generic of Adrenaclick are approved by the Food and Drug Administration and contain the same active ingredient as other epinephrine auto-injector devices. In addition, the American Academy of Allergy, Asthma, and Immunology includes generic Adrenaclick among therapeutic options in an anaphylaxis emergency action plan2.

How can a patient switch a prescription from EpiPen to the lowest-cost epinephrine auto-injector?

First, the patient should speak with his or her prescriber about whether the authorized generic for Adrenaclick is a good fit for their specific medical needs. The prescriber can then write a prescription for an "epinephrine auto-injector" to ensure the lowest-cost product is filled. Patients who already have a prescription on file with CVS Pharmacy can ask their pharmacist to check with the prescriber about making the change.

How does this affect patients who have insurance?

Our pharmacy staff is always available to help patients understand their medication costs under various health insurance and discount plans. This includes exploring every opportunity to enable patients to reduce their out-of-pocket costs by seeking cheaper but effective generic alternatives. In addition to reducing costs for cash-paying customers, these activities can be beneficial to insured patients who have consumer-directed health plans and have not yet met their deductible for the plan year.

See below for Important Safety Information for Epinephrine Injection, USP Auto-Injector

Epinephrine Injection, USP Auto-Injector

Important Safety Information

Indications and Usage

The epinephrine injection, USP auto-injector is indicated in the emergency treatment of allergic reactions (Type I) including anaphylaxis to stinging insects and biting insects, allergen immunotherapy, foods, drugs, diagnostic testing substances, and other allergens, as well as idiopathic anaphylaxis or exercise-induced anaphylaxis.

Warnings and Precautions

Emergency Treatment: The epinephrine injection, USP auto-injector is intended for immediate administration as emergency supportive therapy and is not intended as a substitute for immediate medical care. In conjunction with the administration of epinephrine, the patient should seek immediate medical or hospital care. More than two sequential doses of epinephrine should only be administered under direct medical supervision.

Incorrect Locations of Injection: The epinephrine injection, USP auto-injector should ONLY be injected into the anterolateral aspect of the thigh. Do not inject intravenously. Large doses or accidental intravenous injection of epinephrine may result in cerebral hemorrhage due to a sharp rise in blood pressure. Rapidly acting vasodilators can counteract the marked pressor effects of epinephrine if there is such inadvertent administration. Do not inject into buttock. Injection into the buttock may not provide effective treatment of anaphylaxis. Advise the patient to go immediately to the nearest emergency room for further treatment of anaphylaxis. Injection into the buttock has been associated with the development of Clostridial infections (gas gangrene). Cleansing with alcohol does not kill bacterial spores, and therefore, does not lower the risk. Do not inject into fingers, hands or feet. Since epinephrine is a strong vasoconstrictor, accidental injection into the fingers, hands or feet may result in loss of blood flow to the affected area. Advise the patient to go immediately to the nearest emergency room and to inform the healthcare provider in the emergency room of the location of the accidental injection. Treatment of such inadvertent administration should consist of vasodilation, in addition to further appropriate treatment of anaphylaxis. Hold leg firmly during injection. Lacerations, bent needles, and embedded needles have been reported when epinephrine has been injected into the thigh of young children who are uncooperative and kick or move during an injection. To minimize the risk of injection related injury when administering epinephrine injection, USP auto-injector to young children, instruct caregivers to hold the child's leg firmly in place and limit movement prior to and during injection.

Allergic Reactions Associated with Sulfite: The presence of a sulfite in this product should not deter administration of the drug for treatment of serious allergic or other emergency situations even if the patient is sulfite–sensitive.

Serious Infections at the Injection Site: Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by Clostridia (gas gangrene), have been reported at the injection site following epinephrine injection for anaphylaxis. Clostridium spores can be present on the skin and introduced into the deep tissue with subcutaneous or intramuscular injection.

Disease Interactions: Some patients may be at greater risk for developing adverse reactions after epinephrine administration. Patients with Heart Disease. Epinephrine should be administered with caution to patients who have heart disease, including patients with cardiac arrhythmias, coronary artery or organic heart disease, or hypertension. In such patients, or in patients who are on drugs that may sensitize the heart to arrhythmias, epinephrine may precipitate or aggravate angina pectoris as well as produce ventricular arrhythmias. Other Patients and Diseases. Epinephrine should be administered with caution to patients with hyperthyroidism, diabetes, elderly individuals, and pregnant women. Patients with Parkinson's disease may notice a temporary worsening of symptoms.

Adverse Reactions

Common adverse reactions to systemically administered epinephrine include anxiety; apprehensiveness; restlessness; tremor; weakness; dizziness; sweating; palpitations; pallor; nausea and vomiting; headache, and/or respiratory difficulties.

Arrhythmias, including fatal ventricular fibrillation, have been reported, particularly in patients with underlying cardiac disease or those receiving certain drugs. Rapid rises in blood pressure have produced cerebral hemorrhage, particularly in elderly patients with cardiovascular disease. Angina may occur in patients with coronary artery disease.

Accidental injection into the fingers, hands or feet may result in loss of blood flow to the affected area.

Adverse events experienced as a result of accidental injections may include increased heart rate, local reactions including injection site pallor, coldness and hypoesthesia or injury at the injection site resulting in bruising, bleeding, discoloration, erythema or skeletal injury.

Lacerations, bent needles, and embedded needles have been reported when epinephrine injection, USP auto-injector has been injected into the thigh of young children who are uncooperative and kick or move during an injection.

Injection into the buttock has resulted in cases of gas gangrene.

Rare cases of serious skin and soft tissue infections caused by Clostridia (gas gangrene), have been reported following epinephrine injection in the thigh.

Use in Specific Populations

Elderly patients may be at greater risk of developing adverse reactions.

You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For full prescribing information and video instructions on the use of the epinephrine injection, USP auto-injector, go to www.epinephrineautoinject.com or call 1-888-894-6528.

This website and its contents are intended for use only by residents of the United States. Products discussed may have different label regulatory requirements, and/or medical practices in other countries that may require adherence to different or additional information.

EpiPen® is the registered trademark of Mylan Inc.

Adrenaclick® is the registered trademark of Lineage Therapeutics, Inc., which is a wholly-owned subsidiary of Impax Laboratories, Inc.

1Data on file, Impax Labs: AdrenaClick Auto-injector Formal Summative Study Report, Human Factors Use Model Comparison Study (Human Factors Testing of Adolescents 12 to 18 Years of Age and Adults) (Protocol AM-14-001 v2.1), 2014.

2American Academy of Allergy, Asthma & Immunology (AAAAI)

https://www.aaaai.org/Aaaai/media/MediaLibrary/PDF%20Documents/Libraries/Anaphylaxis-Emergency-Action-Plan.pdf


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