Actoplus Met Xr Oral Tablet, Biphasic Release 15-1000Mg Drug Medication Dosage Information
show timeout overlay link

Your Session Is About to Expire

This online session is about to expire due to inactivity. Click Continue to return to page.

  • myWeekly Ad

Actoplus Met XR: Oral tablet, biphasic release (15-1000mg)

Also see:
  • Get answers to Frequently Asked Questions (FAQs)
  • Find other class related drugs
  • Find additional patient usage statistics

Visit Drug Summary Page
Drug Image file default-drug-image.png
Actoplus Met XR 15-1000mg Tab

What is this Medicine?

METFORMIN; PIOGLITAZONE (met FOR min; pye oh GLI ta zone) helps to treat type 2 diabetes. It helps to control blood sugar. Treatment is combined with diet and exercise.

CVS Pharmacy Patient Statistics for Actoplus Met XR: Oral tablet, biphasic release(15-1000mg)
Generic vs. Brand Name Usage*
*Brand contains same active ingredient but may not represent FDA-approved generic equivalent
Usage By Strength
In-Depth Information

Actoplus Met XR 15mg-1000mg Extended-Release Tablet

NDC: 647640510
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Type 2 Diabetes Mellitus

Storage Information
Avoid excessive humidity
Store at 77 degrees F; excursions permitted to 59-86 degrees F
Avoid excessive heat (above 104 degrees F)
Actoplus Met XR 15mg-1000mg Extended-Release Tablet

Reported Side Effects for Actoplus Met XR 15mg-1000mg Extended-Release Tablet

Electrolyte Imbalance Incidence:
<0.1%*
Severity: SEVERE
Onset: DELAYED
Electrolyte Imbalance Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
Megaloblastic Anemia Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Anemia Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Low Blood Sugar Incidence:
<8.5%*
Severity: MODERATE
Onset: EARLY
Elevated Hepatic Enzymes Incidence:
0.3%*
Severity: MODERATE
Onset: DELAYED
Stomach Pain Incidence:
1.0-10.0%*
Severity: MILD
Onset: EARLY
Gas Incidence:
1.0-10.0%*
Severity: MILD
Onset: EARLY
Metallic Taste Incidence:
1.0-10.0%*
Severity: MILD
Onset: EARLY
Muscle Pain Incidence:
1.0-5.4%*
Severity: MILD
Onset: EARLY
Upset Stomach Incidence:
1.0-10.0%*
Severity: MILD
Onset: EARLY
Feeling Sick Incidence:
1.0-5.0%*
Severity: MILD
Onset: EARLY
Decreased Appetite Incidence:
1.0-10.0%*
Severity: MILD
Onset: DELAYED
Metallic Taste Incidence:
1.0-10.0%*
Severity: MILD
Onset: EARLY
Heart Failure Incidence:
1.1-5.7%*
Severity: SEVERE
Onset: DELAYED
Fluid Retention Incidence:
1.6-26.7%*
Severity: MODERATE
Onset: DELAYED
Weight Gain Incidence:
2.7-13.9%*
Severity: MILD
Onset: DELAYED
Swelling Incidence:
3.0-6.0%*
Severity: MODERATE
Onset: DELAYED
Fluid Retention Incidence:
3.0-6.0%*
Severity: MODERATE
Onset: DELAYED
Upset Stomach Incidence:
3.6-5.8%*
Severity: MILD
Onset: EARLY
Infection Incidence:
4.4-16.0%*
Severity: MILD
Onset: DELAYED
Sinus Infection Incidence:
4.4-5.0%*
Severity: MILD
Onset: DELAYED
Headache Incidence:
4.6-6.0%*
Severity: MILD
Onset: EARLY
Lightheadedness Incidence:
4.8-5.4%*
Severity: MILD
Onset: EARLY
Loose Stools Incidence:
4.8-5.8%*
Severity: MILD
Onset: EARLY
Broken Bones Incidence:
5.1%*
Severity: SEVERE
Onset: DELAYED
Sore Throat Incidence:
5.1%*
Severity: MILD
Onset: DELAYED
Lack Of Vitamin B12 Incidence:
7.0%*
Severity: MODERATE
Onset: DELAYED
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for Actoplus Met XR 15mg-1000mg Extended-Release Tablet

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Moderate Lifestyle Interaction
Alcohol and Actoplus Met XR 15mg-1000mg Extended-Release Tablet(Metformin Hydrochloride)
Alcohol and Metformin Hydrochloride(Metformin Hydrochloride)
Alcohol may interfere with the actions of Antidiabetic agents (Insulin or other drugs used to treat Diabetes). Alcoholic beverages can increase the risk of low blood sugar, or can cause increased blood sugar due to the calories in these beverages. Limit alcohol containing medicines and beverages if you are on Antidiabetic Agents. You should also learn how to recognize the signs of low blood sugar.
Moderate Lifestyle Interaction
Alcohol and Actoplus Met XR 15mg-1000mg Extended-Release Tablet(Pioglitazone Hydrochloride)
Alcohol and Thiazolidinediones(Pioglitazone Hydrochloride)
While a single moderate serviing of alcohol may be okay from time to time, in general excess use of Alcoholic beverages can increase the risk of low blood sugar, or can cause increased blood sugar due to the calories in these beverages. Limit alcohol containing medicines and beverages if you are take medicines for diabetes. You should also learn how to recognize the signs of low blood sugar.
Moderate Lifestyle Interaction
Marijuana and Actoplus Met XR 15mg-1000mg Extended-Release Tablet(Pioglitazone Hydrochloride)
Marijuana and Pioglitazine(Pioglitazone Hydrochloride)
Pioglitazone can theoretically increase the elimination of Marijuana, Medical from the body. The side effects profile of Marijuana, Medical may be altered if you take Pioglitazone. You may feel drowsy or more tired. Do not drive or operate machinery until you know how these drugs affect you. Contact your health care provider immediately if you notice slurred speech, confusion, increases heart rate, or palpitations while taking Marijuana, Medical.
Minor Lifestyle Interaction
Tobacco and Actoplus Met XR 15mg-1000mg Extended-Release Tablet(Metformin Hydrochloride)
Tobacco and Metformin Hydrochloride(Metformin Hydrochloride)
If you use tobacco or are trying to quit tobacco use, you may need to monitor your blood sugar more frequently. Nicotine, a component of tobacco, can increase the blood sugar. Also, if you are trying to quit smoking, as your body adjusts to not smoking, your blood sugar levels may change; the actions of Antidiabetic Agents (medicines used to treat diabetes) may be increased and this could lead to low blood sugar. Know the symptoms of low or high blood sugar and report them if they occur. Monitor your blood sugar regularly.
Minor Lifestyle Interaction
Tobacco and Actoplus Met XR 15mg-1000mg Extended-Release Tablet(Pioglitazone Hydrochloride)
Tobacco and Thiazolidinediones(Pioglitazone Hydrochloride)
If you use tobacco or are trying to quit tobacco use, you may need to monitor your blood sugar more frequently. Nicotine, a component of tobacco, can increase the blood sugar. Also, if you are trying to quit smoking, as your body adjusts to not smoking, your blood sugar levels may change; the actions of Antidiabetic Agents (medicines used to treat diabetes) may be increased and this could lead to low blood sugar. Know the symptoms of low or high blood sugar and report them if they occur. Monitor your blood sugar regularly.
Pregnancy & Lactation Information
FIRST Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

SECOND Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

THIRD Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

Lactation

Caution - Not enough information is available to rule out harm to infants when this drug is taken by nursing mothers.


Learning More About
Visit the Drug Summary page where you can:
  • Get answers to Frequently Asked Questions (FAQs)
  • Find other class related drugs
  • Find additional patient usage statistics
Learn More
Patient Experiences with Actoplus Met XR

Be the first to share your experience!

We want to help our customers stay educated about the medications they are taking. Submit your own observations and experiences to benefit others.

Average Scores
Easy to Take 
0 / 5
0 / 5
Works as Intended 
0 / 5
0 / 5
Tolerable 
0 / 5
0 / 5