Antitussive With Antihistamines Oral Syrup 15-6.25Mg Drug Medication Dosage Information
show timeout overlay link

Your Session Is About to Expire

This online session is about to expire due to inactivity. Click Continue to return to page.

  • myWeekly Ad

Antitussive with Antihistamines: Oral syrup (15-6.25mg)

Also see:
  • Get answers to Frequently Asked Questions (FAQs)
  • Find other class related drugs
  • Find additional patient usage statistics

Visit Drug Summary Page
Drug Image file default-drug-image.png
Promethazine/DM Syrup
Drug Image file default-drug-image.png
Promethazine DM Syrup
Drug Image file default-drug-image.png
Promethazine DM Syrup
Drug Image file default-drug-image.png
Promethazine/DM Syrup

What is this Medicine?

DEXTROMETHORPHAN; PROMETHAZINE (dex troe meth OR fan; proe METH a zeen) is a cough suppressant and an antihistamine. It is used to treat coughing due to colds or allergies. This medicine will not treat an infection.

CVS Pharmacy Patient Statistics for Antitussive with Antihistamines: Oral syrup(15-6.25mg)
Generic vs. Brand Name Usage*
*Brand contains same active ingredient but may not represent FDA-approved generic equivalent
Usage By Strength
In-Depth Information
Select a Medication

Promethazine Hydrochloride/Dextromethorphan Hydrobromide 6.25mg-15mg/5ml Syrup

NDC: 604320604
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Cough, Common Cold

Storage Information
Store at controlled room temperature (between 68 and 77 degrees F)
Promethazine Hydrochloride/Dextromethorphan Hydrobromide 6.25mg-15mg/5ml Syrup
Daily Life Interactions for Promethazine Hydrochloride/Dextromethorphan Hydrobromide 6.25mg-15mg/5ml Syrup

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Major Lifestyle Interaction
Alcohol and Promethazine Hydrochloride/Dextromethorphan Hydrobromide 6.25mg-15mg/5ml Syrup(Promethazine Hydrochloride)
Alcohol and CNS Depressants(Promethazine Hydrochloride)
Avoid alcohol-containing drinks while taking this medicine. Using this drug along with alcohol can lead to serious side effects. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery until you know how this drug affects you, and especially if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Moderate Lifestyle Interaction
Tobacco and Promethazine Hydrochloride/Dextromethorphan Hydrobromide 6.25mg-15mg/5ml Syrup(Promethazine Hydrochloride)
Tobacco and Phenothiazines(Promethazine Hydrochloride)
Tobacco smoking may reduce the effectiveness of this drug in treating your condition; Tobacco smoke contains substances that speed the removal of this drug from the body. Alternatively, if you take this drug and suddenly stop Tobacco smoking, you may feel more drowsy or tired, or may experience confusion, dizziness, difficulty in movement or other side effects. If you will stop smoking, use care in driving or operating machinery until you know how this drug will affect you. Make sure your prescriber is aware that you smoke Tobacco or if you plan to stop smoking. Report any unusual side effects promptly.
Minor Lifestyle Interaction
Grapefruit juice and Promethazine Hydrochloride/Dextromethorphan Hydrobromide 6.25mg-15mg/5ml Syrup(Dextromethorphan Hydrobromide)
Grapefruit juice and Dextromethorphan(Dextromethorphan Hydrobromide)
Grapefruit juice may increase the actions of Dextromethorphan. Side effects from the Dextromethorphan may get worse if you drink grapefruit juice. It may be best to avoid drinking grapefruit juice while you are taking Dextromethorphan.
Pregnancy & Lactation Information
FIRST Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

SECOND Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

THIRD Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.


Learning More About
Visit the Drug Summary page where you can:
  • Get answers to Frequently Asked Questions (FAQs)
  • Find other class related drugs
  • Find additional patient usage statistics
Learn More
Patient Experiences with Antitussive with Antihistamines

We want to help you stay educated about the medications you are taking. View other
patient's observations and share your own.

Be sure to consult your health care provider before taking any medications. Other
patient's comments should not be considered medical advice or health care provider
recommendations.