Combigan Ophthalmic Drops, Solution 0.2-0.5pct Drug Medication Dosage Information
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Combigan: Ophthalmic drops, solution (0.2-0.5%)

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Combigan 0.2%-0.5% Ophth Soln
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Combigan 0.2%-0.5% Ophth Soln

What is this Medicine?

BRIMONIDINE; TIMOLOL (bri MOE ni deen; TYE moe lole) is used in the eye to treat open-angle glaucoma and high pressure in the eyes.

CVS Pharmacy Patient Statistics for Combigan: Ophthalmic drops, solution(0.2-0.5%)
Generic vs. Brand Name Usage*
*Brand contains same active ingredient but may not represent FDA-approved generic equivalent
Usage By Strength
In-Depth Information

Combigan 0.2%-0.5% Ophthalmic Solution

NDC: 000239211
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Glaucoma, Ocular Hypertension

Storage Information
Protect from light
Store between 59 to 77 degrees F
Combigan 0.2%-0.5% Ophthalmic Solution

Reported Side Effects for Combigan 0.2%-0.5% Ophthalmic Solution

Skin Redness Incidence:
<1.0%*
Severity: MODERATE
Onset: EARLY
Rapid Heart Rate Incidence:
<1.0%*
Severity: MODERATE
Onset: RAPID
Peripheral Vasodilation Incidence:
<1.0%*
Severity: MODERATE
Onset: RAPID
Miosis Incidence:
<1.0%*
Severity: MILD
Onset: EARLY
Inflamed Iris (Eye) Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Inflamed Eye Incidence:
<1.0%*
Severity: SEVERE
Onset: EARLY
Visual Impairment Incidence:
1.0-5.0%*
Severity: SEVERE
Onset: EARLY
Dry Eyes Incidence:
1.0-5.0%*
Severity: MILD
Onset: EARLY
Inflamed Eyes Incidence:
1.0-5.0%*
Severity: MODERATE
Onset: EARLY
Eye Drainage Incidence:
1.0-5.0%*
Severity: MILD
Onset: DELAYED
Corneal Erosion Incidence:
1.0-5.0%*
Severity: SEVERE
Onset: DELAYED
Weakness Incidence:
1.0-5.0%*
Severity: MILD
Onset: DELAYED
Depression Incidence:
1.0-5.0%*
Severity: MODERATE
Onset: DELAYED
Eye Irritation Incidence:
1.0-5.0%*
Severity: MILD
Onset: RAPID
Drowsiness Incidence:
1.0-5.0%*
Severity: MILD
Onset: EARLY
Headache Incidence:
1.0-5.0%*
Severity: MILD
Onset: EARLY
Eye Pain Incidence:
1.0-5.0%*
Severity: MILD
Onset: EARLY
High Blood Pressure Incidence:
1.0-5.0%*
Severity: MODERATE
Onset: EARLY
Epiphora Incidence:
1.0-5.0%*
Severity: MODERATE
Onset: EARLY
Foreign Body Sensation Incidence:
1.0-5.0%*
Severity: MILD
Onset: RAPID
Eye Inflammatoin Incidence:
1.0-5.0%*
Severity: SEVERE
Onset: DELAYED
Red Eyes Incidence:
5.0-15.0%*
Severity: MODERATE
Onset: EARLY
Conjunctivitis Incidence:
5.0-15.0%*
Severity: MODERATE
Onset: DELAYED
Itchy Eyes Incidence:
5.0-15.0%*
Severity: MILD
Onset: RAPID
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for Combigan 0.2%-0.5% Ophthalmic Solution

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Major Lifestyle Interaction
Marijuana and Combigan 0.2%-0.5% Ophthalmic Solution(Timolol Maleate)
Marijuana and Beta-blockers(Timolol Maleate)
Do not take Marijuana, Medical and Beta-Blockers (examples: Coreg, Metoprolol or Lopressor or Toprol, Nadolol or Corgard, Propranolol or Inderal) together without talking to your health care provider. Marijuana, Medical may decrease the effectiveness of Beta-Blockers. It is possible that Marijuana, Medical can cause high blood pressure, increased heart rate or other heart-related side effects in persons predisposed to these conditions, which may make the Beta-Blocker-type drug less effective at treating heart or blood pressure related problems.
Moderate Lifestyle Interaction
Alcohol and Combigan 0.2%-0.5% Ophthalmic Solution(Brimonidine Tartrate)
Alcohol and Brimonidine Tartrate(Brimonidine Tartrate)
Avoid or minimize your intake of Ethanol (alcohol-containing drinks) while taking Brimonidine Eye Solution. You may feel drowsy or more tired; do not drive or operate machinery while taking these products together.
Moderate Lifestyle Interaction
Alcohol and Combigan 0.2%-0.5% Ophthalmic Solution(Timolol Maleate)
Alcohol and Antihypertensives(Timolol Maleate)
Although an interaction is possible, Ethanol (alchohol) and Antihypertensive Agents (drugs used to reduce high blood pressure) may be used together. Ethanol or alchohol-containing beverages may increase the effects of Antihypertensive Agents on your blood pressure. If the blood pressure drops too low while taking Ethanol and Antihypertensive Agents, you may become dizzy or feel faint. To limit this interaction, avoid alcohol-containing beverages while taking medicines to lower your blood pressure. Do not stand or sit up too quickly. Contact your prescriber if you have dizziness which does not go away.
Pregnancy & Lactation Information
FIRST Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

SECOND Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

THIRD Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

Lactation

Caution - Not enough information is available to rule out harm to infants when this drug is taken by nursing mothers.


Learning More About
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