Depakene Oral Solution 250Mg Drug Medication Dosage Information
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Depakene: Oral solution (250mg)

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Depakene 250mg/5ml Soln

What is this Medicine?

VALPROIC ACID (val PROE ik AS id) is used to treat certain types of seizures in patients with epilepsy.

CVS Pharmacy Patient Statistics for Depakene: Oral solution(250mg)
Generic vs. Brand Name Usage*
*Brand contains same active ingredient but may not represent FDA-approved generic equivalent
Usage By Strength
In-Depth Information

Depakene 250mg/5ml Solution

NDC: 000745682
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Myoclonic Seizures, Absence Seizures, Tonic-clonic Seizures, Partial Seizures

Sometimes used for but not FDA approved for the following conditions:
Agitation, Singultus (hiccups), Diabetic Neuropathy, Nystagmus

Storage Information
Store below 86 degrees F
Depakene 250mg/5ml Solution

Reported Side Effects for Depakene 250mg/5ml Solution

Elated Mood Incidence:
<0.9%*
Severity: MODERATE
Onset: EARLY
Sore Throat Incidence:
0.6-8.0%*
Severity: MILD
Onset: DELAYED
Hypoesthesia Incidence:
0.6%*
Severity: MILD
Onset: DELAYED
Paresthesias Incidence:
0.9-5.0%*
Severity: MILD
Onset: DELAYED
Peripheral Vasodilation Incidence:
0.9-5.0%*
Severity: MODERATE
Onset: RAPID
Loose Stools Incidence:
0.9-23.0%*
Severity: MILD
Onset: EARLY
Mouth Sores Incidence:
>1.0%*
Severity: MODERATE
Onset: DELAYED
Chills Incidence:
>1.0%*
Severity: MILD
Onset: RAPID
Blistery Rash Incidence:
>1.0%*
Severity: MODERATE
Onset: EARLY
Abnormal Heart Rhythm Incidence:
>1.0%*
Severity: SEVERE
Onset: EARLY
Light Sensitivity Incidence:
>1.0%*
Severity: MODERATE
Onset: EARLY
Rash Of Red Skin Bumps Incidence:
>1.0%*
Severity: SEVERE
Onset: DELAYED
Low Platelet Count Incidence:
1.0-27.0%*
Severity: MODERATE
Onset: DELAYED
Ringing In Ears Incidence:
1.0-5.0%*
Severity: MILD
Onset: DELAYED
Vesicular Rash Incidence:
>1.0%*
Severity: MILD
Onset: DELAYED
Difficulty Swallowing Incidence:
>1.0%*
Severity: MODERATE
Onset: DELAYED
Shortness Of Breath Incidence:
1.0-5.0%*
Severity: MODERATE
Onset: EARLY
Hiccups Incidence:
>1.0%*
Severity: MILD
Onset: EARLY
Fast Eye Movements Incidence:
1.0-7.0%*
Severity: MODERATE
Onset: DELAYED
Excessive Mucle Tone Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: DELAYED
Vomiting Of Blood Incidence:
1.1-5.0%*
Severity: SEVERE
Onset: DELAYED
Deafness Incidence:
1.1-5.0%*
Severity: SEVERE
Onset: DELAYED
Painful Urination Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: EARLY
Swelling Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: DELAYED
Inflamed Tongue Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: EARLY
Nose Bleed Incidence:
1.1-5.0%*
Severity: MILD
Onset: DELAYED
Menstrual Cramps Incidence:
1.1-5.0%*
Severity: MILD
Onset: DELAYED
Overactive Reflexes Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: DELAYED
Increased Urination Incidence:
1.1-5.0%*
Severity: MILD
Onset: EARLY
Drowsiness Incidence:
1.1-26.0%*
Severity: MILD
Onset: EARLY
Fecal Incontinence Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: EARLY
Distressed Incidence:
1.1-5.0%*
Severity: MILD
Onset: EARLY
Hair Loss Incidence:
1.1-7.0%*
Severity: MILD
Onset: DELAYED
Lazy Eye Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: DELAYED
Weight Gain Incidence:
1.1-9.0%*
Severity: MILD
Onset: DELAYED
No Menstrual Periods Incidence:
1.1-7.0%*
Severity: MILD
Onset: DELAYED
Decreased Appetite Incidence:
1.1-11.0%*
Severity: MILD
Onset: DELAYED
Nervousness Incidence:
1.1-5.0%*
Severity: MILD
Onset: DELAYED
Rapid Heart Rate Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: RAPID
Dandruff Incidence:
1.1-5.0%*
Severity: MILD
Onset: DELAYED
Rhinitis Incidence:
1.1-5.0%*
Severity: MILD
Onset: EARLY
Skin Rash Incidence:
1.1-6.0%*
Severity: MILD
Onset: EARLY
Red Spotted Rash Incidence:
1.1-5.0%*
Severity: MILD
Onset: DELAYED
Rapid Heart Rate Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: EARLY
Ear Pain Incidence:
1.1-5.0%*
Severity: MILD
Onset: EARLY
Muscle Weakness Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: DELAYED
Feeling Sick Incidence:
1.1-5.0%*
Severity: MILD
Onset: EARLY
Rash With Pustules Incidence:
1.1-5.0%*
Severity: MILD
Onset: EARLY
Constipation Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: DELAYED
Cough Incidence:
1.1-5.0%*
Severity: MILD
Onset: DELAYED
Bladder Infection Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: DELAYED
Lupus-like Symptoms Incidence:
1.1-5.0%*
Severity: SEVERE
Onset: DELAYED
Depression Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: DELAYED
Low Blood Pressure Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: RAPID
Vaginal Bleeding Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: DELAYED
Tardive Dyskinesia Incidence:
1.1-5.0%*
Severity: SEVERE
Onset: DELAYED
Inability To Sleep Incidence:
1.1-15.0%*
Severity: MILD
Onset: EARLY
Muscle Pain Incidence:
1.1-5.0%*
Severity: MILD
Onset: EARLY
Fluid Retention Incidence:
1.1-8.0%*
Severity: MODERATE
Onset: DELAYED
Inflamed Pancreas Incidence:
1.1-5.0%*
Severity: SEVERE
Onset: DELAYED
Muscle Cramps Incidence:
1.1-5.0%*
Severity: MILD
Onset: DELAYED
Irregular Periods Incidence:
1.1-5.0%*
Severity: MILD
Onset: DELAYED
Flu Incidence:
1.1-5.0%*
Severity: MILD
Onset: DELAYED
Infection Incidence:
1.1-5.0%*
Severity: MILD
Onset: DELAYED
Eye Pain Incidence:
1.1-5.0%*
Severity: MILD
Onset: EARLY
Postural Low Blood Pressure Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: DELAYED
Stomach Pain Incidence:
1.1-12.0%*
Severity: MILD
Onset: EARLY
Dry Mouth Incidence:
1.1-5.0%*
Severity: MILD
Onset: EARLY
Dry Skin Incidence:
1.1-5.0%*
Severity: MILD
Onset: DELAYED
Dry Eyes Incidence:
1.1-5.0%*
Severity: MILD
Onset: EARLY
Balance Problems Incidence:
1.1-5.0%*
Severity: MILD
Onset: EARLY
Vaginal Infection Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: DELAYED
Uncontrolled Urination Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: EARLY
Shaking Incidence:
1.1-9.0%*
Severity: MILD
Onset: EARLY
Mouth Ulcers Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: DELAYED
Sinus Infection Incidence:
1.1-5.0%*
Severity: MILD
Onset: DELAYED
Itching Incidence:
1.1-5.0%*
Severity: MILD
Onset: RAPID
Fever Incidence:
1.1-5.0%*
Severity: MILD
Onset: EARLY
Gas Incidence:
1.1-5.0%*
Severity: MILD
Onset: EARLY
Belching Incidence:
1.1-5.0%*
Severity: MILD
Onset: EARLY
Boils Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: DELAYED
Emotional Lability Incidence:
1.1-5.0%*
Severity: MILD
Onset: EARLY
Elevated Hepatic Enzymes Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: DELAYED
Bruise Incidence:
1.1-5.0%*
Severity: MILD
Onset: DELAYED
Metallic Taste Incidence:
1.1-5.0%*
Severity: MILD
Onset: EARLY
Dysarthria Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: DELAYED
Lightheadedness Incidence:
1.1-12.0%*
Severity: MILD
Onset: EARLY
Conjunctivitis Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: DELAYED
Confusion Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: EARLY
Chest Pain Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: EARLY
Blurred Vision Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: EARLY
Back Pain Incidence:
1.1-8.0%*
Severity: MILD
Onset: DELAYED
Incoordination Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: DELAYED
Arthropathy Incidence:
1.1-5.0%*
Severity: MILD
Onset: DELAYED
Causing To Be Hungry Incidence:
1.1-6.0%*
Severity: MILD
Onset: DELAYED
High Blood Pressure Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: EARLY
Loss Of Memory Incidence:
1.1-5.0%*
Severity: MODERATE
Onset: DELAYED
Vomiting Incidence:
1.3-23.0%*
Severity: MILD
Onset: EARLY
Hirsutism Incidence:
3.0%*
Severity: MILD
Onset: DELAYED
Upset Stomach Incidence:
3.2-34.0%*
Severity: MILD
Onset: EARLY
Headache Incidence:
4.3%*
Severity: MILD
Onset: EARLY
Weakness Incidence:
6.0-20.0%*
Severity: MILD
Onset: DELAYED
Upset Stomach Incidence:
7.0-23.0%*
Severity: MILD
Onset: EARLY
Light Menstrual Period Incidence:
14.0%*
Severity: MILD
Onset: DELAYED
Double Vision Incidence:
16.0%*
Severity: MILD
Onset: EARLY
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for Depakene 250mg/5ml Solution

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Moderate Lifestyle Interaction
Alcohol and Depakene 250mg/5ml Solution(Valproic Acid)
Alcohol and Valproic Acid(Valproic Acid)
Ethanol may decrease the actions of Valproic Acid, Divalproex Sodium (Depakote, Depakene). In general, it is best to limit or avoid alcoholic beverages while on Valproic acid or Divalproex. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery while drinking alcoholic beverages.
Moderate Lifestyle Interaction
Marijuana and Depakene 250mg/5ml Solution(Valproic Acid)
Marijuana and Valproic Acid(Valproic Acid)
Valproic Acid, Divalproex Sodium can theoretically decrease the elimination of Marijuana, Medical from the body. Side effects from Marijuana, Medical may get worse if you take Valproic Acid, Divalproex Sodium. You may feel drowsy or more tired. Do not drive or operate machinery until you know how these drugs affect you. Contact your health care provider immediately if you notice slurred speech, confusion, increases heart rate, or palpitations while taking Marijuana, Medical.
Pregnancy & Lactation Information
FIRST Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

SECOND Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

THIRD Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

Lactation

Caution - Not enough information is available to rule out harm to infants when this drug is taken by nursing mothers.


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Patient Experiences with Depakene

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