Diflunisal Oral Tablet 500Mg Drug Medication Dosage Information
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Diflunisal: Oral tablet (500mg)

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Drug Image file DrugItem_1915.JPG
Diflunisal 500mg Tab
Teva Pharmaceuticals USA Inc
Pill Identification: 755/93 
Drug Image file DrugItem_23125.JPG
Diflunisal 500mg Tab
Rising Pharmaceuticals Inc
Pill Identification: EP 170 

What is this Medicine?

DIFLUNISAL (dye FLOO ni sal) is used to treat osteoarthritis, rheumatoid arthritis, or mild to moderate pain.

Similar Brand Name Drugs : Dolobid: Oral tablet (500mg)
CVS Pharmacy Patient Statistics for Diflunisal: Oral tablet(500mg)
Generic vs. Brand Name Usage*
*Brand contains same active ingredient but may not represent FDA-approved generic equivalent
Usage By Strength
In-Depth Information
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Diflunisal 500mg Tablet

NDC: 000930755
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Mild Pain, Moderate Pain, Rheumatoid Arthritis, Osteoarthritis

Sometimes used for but not FDA approved for the following conditions:
Bone Pain, Dysmenorrhea, Migraine, Myalgia, Arthralgia, Dental Pain, Headache

Storage Information
Store between 59 to 77 degrees F, limited excursions permitted up to 86 degrees F
Diflunisal 500mg Tablet
Drug Image file DrugItem_1915.JPG
Teva Pharmaceuticals USA Inc
Pill Identification: 755/93 
Shape: oblong
Color: blue

Reported Side Effects for Diflunisal 500mg Tablet

Blood In The Urine Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Liver Infection Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Yellow Skin Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Anaphylactoid Reactions Incidence:
<1.0%*
Severity: SEVERE
Onset: RAPID
Weakness Incidence:
<1.0%*
Severity: MILD
Onset: DELAYED
Blurred Vision Incidence:
<1.0%*
Severity: MODERATE
Onset: EARLY
Breathing Difficulties Incidence:
<1.0%*
Severity: SEVERE
Onset: RAPID
Confusion Incidence:
<1.0%*
Severity: MODERATE
Onset: EARLY
Diaphoresis Incidence:
<1.0%*
Severity: MILD
Onset: EARLY
Elevated Hepatic Enzymes Incidence:
<15.0%*
Severity: MODERATE
Onset: DELAYED
Belching Incidence:
<1.0%*
Severity: MILD
Onset: EARLY
Flushing Incidence:
<1.0%*
Severity: MILD
Onset: RAPID
Hallucinations Incidence:
<1.0%*
Severity: MODERATE
Onset: EARLY
Kidney Inflammation Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Paresthesias Incidence:
<1.0%*
Severity: MILD
Onset: DELAYED
Photosensitivity Incidence:
<1.0%*
Severity: MILD
Onset: DELAYED
Kidney Failure Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Lyell'S Syndrome Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Visual Impairment Incidence:
<1.0%*
Severity: SEVERE
Onset: EARLY
Erythema Multiforme Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Exfoliative Dermatitis Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Painful Urination Incidence:
<1.0%*
Severity: MODERATE
Onset: EARLY
Inflamed Stomach Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Hemolytic Anemia Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Protein In The Urine Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Itching Incidence:
<1.0%*
Severity: MILD
Onset: RAPID
Depression Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Stevens-Johnson Syndrome Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Mouth Ulcers Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Low Platelet Count Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Hives Incidence:
<1.0%*
Severity: MILD
Onset: RAPID
Balance Problems Incidence:
<1.0%*
Severity: MILD
Onset: EARLY
Decreased Appetite Incidence:
<1.0%*
Severity: MILD
Onset: DELAYED
No White Blood Cells Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Angioedema Incidence:
<1.0%*
Severity: SEVERE
Onset: RAPID
Anemia Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Cholestasis Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Stomach Ulcer Incidence:
1.0-4.0%*
Severity: SEVERE
Onset: DELAYED
Constipation Incidence:
1.0-3.0%*
Severity: MODERATE
Onset: DELAYED
Drowsiness Incidence:
1.0-3.0%*
Severity: MILD
Onset: EARLY
Tired Incidence:
1.0-3.0%*
Severity: MILD
Onset: EARLY
Gas Incidence:
1.0-3.0%*
Severity: MILD
Onset: EARLY
Lightheadedness Incidence:
1.0-3.0%*
Severity: MILD
Onset: EARLY
Inability To Sleep Incidence:
1.0-3.0%*
Severity: MILD
Onset: EARLY
Vomiting Incidence:
1.0-3.0%*
Severity: MILD
Onset: EARLY
Ringing In Ears Incidence:
1.0-3.0%*
Severity: MILD
Onset: DELAYED
Hole In Intestines Incidence:
1.0-4.0%*
Severity: SEVERE
Onset: DELAYED
Intestinal Bleeding Incidence:
1.0-4.0%*
Severity: SEVERE
Onset: DELAYED
Upset Stomach Incidence:
3.0-9.0%*
Severity: MILD
Onset: EARLY
Headache Incidence:
3.0-9.0%*
Severity: MILD
Onset: EARLY
Loose Stools Incidence:
3.0-9.0%*
Severity: MILD
Onset: EARLY
Skin Rash Incidence:
3.0-9.0%*
Severity: MILD
Onset: EARLY
Stomach Pain Incidence:
3.0-9.0%*
Severity: MILD
Onset: EARLY
Upset Stomach Incidence:
3.0-9.0%*
Severity: MILD
Onset: EARLY
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for Diflunisal 500mg Tablet

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Major Lifestyle Interaction
Alcohol and Diflunisal 500mg Tablet(Diflunisal)
Alcohol and Salicylates(Diflunisal)
Side effects from this drug may get worse if you drink alcohol-containing drinks. If you have persistent stomach upset, vomit blood or what looks like coffee grounds, or have black, tarry stools, contact your health care provider immediately. Avoid alcohol containing drinks while taking aspirin. Alcohol intake should be limited even with short term use of aspirin or related pain relievers.
Moderate Lifestyle Interaction
Tobacco and Diflunisal 500mg Tablet(Diflunisal)
Tobacco and Diflunisal(Diflunisal)
Side effects from Nonsteroidal anti-inflammatory drugs may get worse if you use tobacco-containing products such as cigarettes. If you have persistent stomach upset, vomit blood or what looks like coffee grounds, or have black, tarry stools, contact your health care provider immediately. Many non-prescription products contain NSAIDs; closely read labels before taking any medicines. Eye or Skin products containing NSAIDs should not interact with tobacco.
Pregnancy & Lactation Information
FIRST Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

SECOND Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

THIRD Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

Lactation

Caution - Not enough information is available to rule out harm to infants when this drug is taken by nursing mothers.


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