Dihydroergotamine Nasal Spray, Solution 4Mg Drug Medication Dosage Information
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Dihydroergotamine: Nasal spray, solution (4mg)

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What is this Medicine?

DIHYDROERGOTAMINE (dye hye droe er GOT a meen) is part of a group of medicines called ergot alkaloids. It is used to treat migraine headaches with or without aura. It should not be used to prevent migraine headaches.

Similar Brand Name Drugs : Migranal: Nasal spray, solution (4mg)
In-Depth Information

Dihydroergotamine Mesylate 4mg/ml Nasal Spray

NDC: 686820357
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Migraine, Cluster Headache

Storage Information
Do not refrigerate
Do not freeze
Store below 77 degrees F
Dihydroergotamine Mesylate 4mg/ml Nasal Spray

Reported Side Effects for Dihydroergotamine Mesylate 4mg/ml Nasal Spray

Hives Incidence:
<0.1%*
Severity: MILD
Onset: RAPID
Vaginal Infection Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
Breathing Difficulties Incidence:
<0.1%*
Severity: SEVERE
Onset: RAPID
Hyperkinesis Incidence:
<0.1%*
Severity: MILD
Onset: DELAYED
Inflamed Vocal Cords Incidence:
<0.1%*
Severity: MILD
Onset: DELAYED
Rash With Pustules Incidence:
<0.1%*
Severity: MILD
Onset: EARLY
Rapid Muscle Twitches Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
Nose Bleed Incidence:
<0.1%*
Severity: MILD
Onset: DELAYED
Extra Saliva Production Incidence:
<0.1%*
Severity: MILD
Onset: EARLY
Yawning Incidence:
<0.1%*
Severity: MILD
Onset: EARLY
High Blood Pressure Incidence:
<1.0%*
Severity: MODERATE
Onset: EARLY
Low Blood Pressure Incidence:
<0.1%*
Severity: MODERATE
Onset: RAPID
Depression Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
Chest Pain Incidence:
<0.1%*
Severity: MODERATE
Onset: EARLY
Decreased Appetite Incidence:
<0.1%*
Severity: MILD
Onset: DELAYED
Nervousness Incidence:
<0.1%*
Severity: MILD
Onset: DELAYED
Joint Pain Incidence:
<0.1%*
Severity: MILD
Onset: DELAYED
Eye Pain Incidence:
<0.1%*
Severity: MILD
Onset: EARLY
Migraine Incidence:
<0.1%*
Severity: MODERATE
Onset: EARLY
Hiccups Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Feeling Sick Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Weakness Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Hypoesthesia Incidence:
0.1-1.0%*
Severity: MILD
Onset: DELAYED
Secretion Of Tears Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Upset Stomach Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Elated Mood Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: EARLY
Dystonic Reaction Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Dysosmia Incidence:
0.1-1.0%*
Severity: MILD
Onset: DELAYED
Rapid Heart Rate Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: EARLY
Bladder Infection Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Shortness Of Breath Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: EARLY
Itching Incidence:
0.1-1.0%*
Severity: MILD
Onset: RAPID
Light Sensitivity Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: EARLY
Ringing In Ears Incidence:
0.1-1.0%*
Severity: MILD
Onset: DELAYED
Shaking Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Muscle Pain Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Balance Problems Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Inability To Sleep Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Stomach Pain Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Difficulty Swallowing Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Muscle Cramps Incidence:
0.1-1.0%*
Severity: MILD
Onset: DELAYED
Inceased Urination Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Skin Rash Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Red Spotted Rash Incidence:
0.1-1.0%*
Severity: MILD
Onset: DELAYED
Fever Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Visual Impairment Incidence:
0.1-1.0%*
Severity: SEVERE
Onset: EARLY
Chills Incidence:
0.1-1.0%*
Severity: MILD
Onset: RAPID
Confusion Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: EARLY
Conjunctivitis Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Diaphoresis Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Weakness Incidence:
1.0%*
Severity: MILD
Onset: DELAYED
Dry Mouth Incidence:
1.0%*
Severity: MILD
Onset: EARLY
Sinus Infection Incidence:
1.0%*
Severity: MILD
Onset: DELAYED
Hot Flashes Incidence:
1.0%*
Severity: MODERATE
Onset: EARLY
Tired Incidence:
1.0%*
Severity: MILD
Onset: EARLY
Paresthesias Incidence:
2.0%*
Severity: MILD
Onset: DELAYED
Loose Stools Incidence:
2.0%*
Severity: MILD
Onset: EARLY
Sore Throat Incidence:
3.0%*
Severity: MILD
Onset: DELAYED
Drowsiness Incidence:
3.0%*
Severity: MILD
Onset: EARLY
Lightheadedness Incidence:
4.0%*
Severity: MILD
Onset: EARLY
Vomiting Incidence:
4.0%*
Severity: MILD
Onset: EARLY
Metallic Taste Incidence:
8.0%*
Severity: MILD
Onset: EARLY
Upset Stomach Incidence:
10.0%*
Severity: MILD
Onset: EARLY
Rhinitis Incidence:
26.0%*
Severity: MILD
Onset: EARLY
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for Dihydroergotamine Mesylate 4mg/ml Nasal Spray

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Major Lifestyle Interaction
Tobacco and Dihydroergotamine Mesylate 4mg/ml Nasal Spray(Dihydroergotamine Mesylate)
Tobacco and Ergot Alkaloids(Dihydroergotamine Mesylate)
It is recommended to avoid nicotine (examples: Nicotine patches or gum) and tobacco while taking any Ergot-type medications. Side effects from Ergot Alkaloids may get worse if you take Nicotine or if you smoke tobacco. Side effects might include anxiety, chest pain, numbness in the fingers or toes, tingling, or vision changes.
Major Lifestyle Interaction
Grapefruit juice and Dihydroergotamine Mesylate 4mg/ml Nasal Spray(Dihydroergotamine Mesylate)
Grapefruit juice and Dihydroergotamine Mesylate(Dihydroergotamine Mesylate)
Taking grapefruit juice with Dihydroergotamine might increase the risk of nausea, nervousness, chest pain, high blood pressure, palpitations, or other serious side effects, like pain, numbness or reduced circulation to the hands, feet or legs.Use caution by not changing the amount of grapefruit juice you drink while taking Dihydroergotamine.
Pregnancy & Lactation Information
FIRST Trimester

Class X - Adequate well-controlled or observational studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities or risks. The use of the product is contraindicated in women who are or may become pregnant.

SECOND Trimester

Class X - Adequate well-controlled or observational studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities or risks. The use of the product is contraindicated in women who are or may become pregnant.

THIRD Trimester

Class X - Adequate well-controlled or observational studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities or risks. The use of the product is contraindicated in women who are or may become pregnant.

Lactation

Avoid - This drug is known to cause harm to infants when taken by nursing mothers.


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