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Diphenhydramine: Oral tablet

Also see:
  • Reported side effects
  • Daily life interactions

Available Strengths
Drug Image file DrugItem_13320.JPG
Allergy 25mg Tablet
Publix Super Markets, Inc
Pill Identification: L479  |  25
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Nighttime Sleep Aid 25mg Tab
AmerisourceBergen Corporation
Pill Identification: L431 
Drug Image file DrugItem_14723.JPG
Allergyl 25mg Tab
AmerisourceBergen Corporation
Pill Identification: L479  |  25
Drug Image file DrugItem_691.JPG
Allergyl 25mg Tab
AmerisourceBergen Corporation
Pill Identification: L479  |  25
Drug Image file DrugItem_16841.JPG
Diphenhist 25mg Tab
Rugby Laboratories a Division of The Harvard Drug Group, LLC
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Diphenhydramine 25mg Tab
United Research Laboratories, Inc. a subsidiary of Sun Pharmaceutical Industries, Inc.
Pill Identification: K 115 
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Nighttime Sleep-Aid 25mg Tab
CVS Pharmacy, Inc
Pill Identification: 44-367 
Drug Image file DrugItem_9274.JPG
Sleep Aid 25mg NT Caplet
Walgreen Co
Pill Identification: 44-367 
Drug Image file DrugItem_8299.JPG
Diphenhist 25mg Tab
Rugby Laboratories a Division of The Harvard Drug Group, LLC
Drug Image file DrugItem_9278.JPG
Sleep II Tab
Walgreen Co
Pill Identification: 44 189 
Drug Image file DrugItem_9434.JPG
Wal-dryl Allergy Minitab
Walgreen Co
Pill Identification: 44-329 
Drug Image file DrugItem_2668.JPG
GS Diphedryl 25mg Tab
Goodsense a Division of Perrigo
Pill Identification: 205 
Drug Image file DrugItem_16250.JPG
BANOPHEN 25mg Minitabs
Major Pharmaceuticals Inc
Pill Identification: 44-329 
Drug Image file DrugItem_4681.JPG
Diphedryl 25mg Tab
Cardinal Health
Pill Identification: 205 
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Diphedryl 25mg Tab
Cardinal Health
Pill Identification: 205 
How This Drug Works
Antihistamines, H1
Histamine antagonists or antihistamines are drugs that relieve allergy symptoms. Histamine is a chemical used to identify and remove substances that trigger an allergic response.
Histamine antagonists or antihistamines are drugs that relieve allergy symptoms.<br><br>Histamine is a chemical used to identify and remove substances that trigger an allergic response.  There are four histamine receptors &#40;designated H<sub>1</sub>, H<sub>2</sub>, H<sub>3</sub>, H<sub>4</sub>&#41;. When histamine activates H<sub>1</sub> receptors, symptoms such as rashes, itching, watery eyes and trouble breathing may begin. <br><br>Antihistamines prevent histamine from stimulating the H<sub>1</sub> receptors located in the eyes, nose and throat to relieve swelling and stop leaking fluid.  First generation antihistamines were non-selective for H<sub>1</sub> receptors and crossed into the brain resulting in drowsiness.  Newer antihistamines are more selective, reducing this side effect.
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Frequently Asked Questions (FAQs) on Diphenhydramine: Oral tablet

What is this medicine?

DIPHENHYDRAMINE (dye fen HYE dra meen) is an antihistamine. It is used to treat the symptoms of an allergic reaction. It is also used to treat Parkinson's disease. This medicine is also used to prevent and to treat motion sickness and as a nighttime sleep aid.


What should I tell my health care provider before I take this medicine?

How should I use this medicine?

What if I miss a dose?

What may interact with this medicine?

What should I watch for while using this medicine?

What side effects may I notice from receiving this medicine?

Where should I keep my medicine?

Drugs Related by Class to Diphenhydramine: Oral tablet
Previous Class name
Class Name : First generation (sedating) Antihistamines

Related Brand Name Drugs :

AHIST: Oral tablet  |  Aldex AN: Chewable tablet  |  Alka-Seltzer Plus Allergy: Oral tablet  |  Aller-Chlor: Oral tablet  |  Arbinoxa: Oral solution  |  Arbinoxa: Oral tablet  |  Atarax: Oral solution  |  Atarax: Oral tablet  |  Benadryl Allergy Children's: Oral solution  |  Benadryl Allergy Dye Free: Oral capsule  |  Benadryl Allergy Dye Free: Oral capsule, liquid filled  |  Benadryl Allergy Kapgel: Oral tablet  |  Benadryl Allergy Ultratab: Oral tablet  |  Benadryl Allergy: Oral capsule  |  Benadryl Allergy: Oral solution  |  Benadryl Children's Allergy Fastmelt: Oral disintegrating tablet  |  Benadryl Children's Allergy: Chewable tablet  |  Benadryl Children's Allergy: Oral solution  |  Benadryl Children's Perfect Measure: Oral solution  |  Benadryl: Solution for injection  |  Benadryl: Topical cream  |  Benadryl: Topical solution  |  Benadryl: Topical spray, solution  |  BroveX CT: Chewable tablet  |  Chlor-Trimeton Allergy 12 Hour: Oral tablet, extended release 12 hour  |  Chlor-Trimeton Allergy: Oral tablet  |  Chlor-Trimeton: Oral tablet  |  Chlorphen SR: Oral tablet, extended release 12 hour  |  Doxytex: Oral solution  |  ElixSure Allergy: Oral solution  |  Histex PD: Oral solution  |  Lodrane: Oral capsule  |  Lodrane: Oral tablet, extended release  |  Nytol: Oral capsule, liquid filled  |  Nytol: Oral tablet  |  Palgic: Oral solution  |  Palgic: Oral tablet  |  PediaCare Children's Allergy: Oral solution  |  PediaCare Nighttime Cough: Oral solution  |  Pediox: Oral solution  |  Periactin: Oral tablet  |  Respa-BR: Oral tablet, extended release  |  RyVent: Oral tablet  |  Tavist Allergy: Oral tablet  |  Unisom: Oral capsule, liquid filled  |  Unisom: Oral tablet  |  VANAHIST PD: Oral solution  |  VanaClear PD: Oral solution  |  Vistaril: Oral capsule  |  Vistaril: Oral suspension  |  Vistaril: Solution for injection
Most Commonly Used Drugs by Class

Related Generic Drugs :

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CVS Pharmacy Patient Statistics for Diphenhydramine: Oral tablet
Usage by Gender
62.7%
37.3%
Generic vs. Brand Name Usage*
*Brand contains same active ingredient but may not represent FDA-approved generic equivalent
Usage by Age
25.39%
17.55%
36.05%
21.0%
In-Depth Information on This Drug
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  • Reported side effects
  • Daily life interactions
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Patient Experiences with Diphenhydramine

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Average Scores
Easy to Take 
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Works as Intended 
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Tolerable 
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