Imbruvica Oral Capsule 140Mg Drug Medication Dosage Information
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IMBRUVICA: Oral capsule (140mg)

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What is this Medicine?

IBRUTINIB (eye BROO ti nib) is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat mantle cell lymphoma, chronic lymphocytic leukemia, small lymphocytic lymphoma, marginal zone lymphoma, and Waldenstrom macroglobulinemia.

In-Depth Information

IMBRUVICA 140mg Capsule

NDC: 579620140
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Mantle Cell Lymphoma (MCL), Chronic Lymphocytic Leukemia (CLL), Macroglobulinemia

Storage Information
Store in original container
Store between 68 to 77 degrees F, excursions permitted 59 to 86 degrees F
IMBRUVICA 140mg Capsule

Reported Side Effects for IMBRUVICA 140mg Capsule

Brain Bruise Incidence:
<6.0%*
Severity: SEVERE
Onset: EARLY
Skin Rash Incidence:
<4.0%*
Severity: SEVERE
Onset: EARLY
Secretion Of Tears Incidence:
<13.0%*
Severity: MILD
Onset: EARLY
Weakness Incidence:
<4.0%*
Severity: SEVERE
Onset: DELAYED
Muscle Cramps Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Bleeding In The Brain Incidence:
<6.0%*
Severity: SEVERE
Onset: DELAYED
Blood In The Urine Incidence:
<6.0%*
Severity: SEVERE
Onset: DELAYED
Intestinal Bleeding Incidence:
<6.0%*
Severity: SEVERE
Onset: DELAYED
Bleeding Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Dry Eyes Incidence:
<17.0%*
Severity: MILD
Onset: EARLY
Sinus Infection Incidence:
<6.0%*
Severity: SEVERE
Onset: DELAYED
Joint Pain Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Shortness Of Breath Incidence:
<4.0%*
Severity: SEVERE
Onset: EARLY
Anemia Incidence:
<9.0%*
Severity: SEVERE
Onset: DELAYED
Tired Incidence:
<5.0%*
Severity: SEVERE
Onset: EARLY
Fever Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Headache Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Muscle And/Or Bone Pain Incidence:
1.0-6.0%*
Severity: SEVERE
Onset: EARLY
Decreased Appetite Incidence:
2.0%*
Severity: SEVERE
Onset: DELAYED
Fluid Retention Incidence:
>3.0%*
Severity: SEVERE
Onset: DELAYED
High Blood Pressure Incidence:
4.0-8.0%*
Severity: SEVERE
Onset: EARLY
Dehydration Incidence:
4.0%*
Severity: SEVERE
Onset: DELAYED
Low Platelet Count Incidence:
5.0-17.0%*
Severity: SEVERE
Onset: DELAYED
Secondary Malignancy Incidence:
5.0-16.0%*
Severity: MODERATE
Onset: DELAYED
Irregular Heart Beat Incidence:
6.0-9.0%*
Severity: SEVERE
Onset: EARLY
Irregular Heart Rate Incidence:
6.0-9.0%*
Severity: SEVERE
Onset: EARLY
Infection Incidence:
8.0-26.0%*
Severity: SEVERE
Onset: DELAYED
Nerve Pain Incidence:
10.0%*
Severity: MODERATE
Onset: DELAYED
Blurred Vision Incidence:
10.0-13.0%*
Severity: MODERATE
Onset: EARLY
Inability To Sleep Incidence:
10.0%*
Severity: MILD
Onset: EARLY
Nervousness Incidence:
10.0%*
Severity: MILD
Onset: DELAYED
Red Spotted Rash Incidence:
11.0-17.0%*
Severity: MILD
Onset: DELAYED
Visual Impairment Incidence:
11.0%*
Severity: SEVERE
Onset: EARLY
Lightheadedness Incidence:
11.0-21.0%*
Severity: MILD
Onset: EARLY
Nose Bleed Incidence:
11.0-19.0%*
Severity: MILD
Onset: DELAYED
Heartburn Incidence:
13.0%*
Severity: MILD
Onset: DELAYED
Chills Incidence:
13.0%*
Severity: MILD
Onset: RAPID
Arthropathy Incidence:
13.0%*
Severity: MILD
Onset: DELAYED
Cough Incidence:
13.0-22.0%*
Severity: MILD
Onset: DELAYED
High Uric Acid Level Incidence:
15.0-40.0%*
Severity: MODERATE
Onset: DELAYED
Low White Blood Cells Incidence:
19.0-29.0%*
Severity: SEVERE
Onset: DELAYED
High Lymphocytes Incidence:
33.0-66.0%*
Severity: MODERATE
Onset: DELAYED
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for IMBRUVICA 140mg Capsule

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Severe Lifestyle Interaction
Grapefruit juice and IMBRUVICA 140mg Capsule(Ibrutinib)
Grapefruit juice and Ibrutinib(Ibrutinib)
Do not take these drugs together. Discuss possible alternative treatment options with your health care provider. Taking these drugs together can increase the risk of bleeding, infection, low blood counts, and other ibrutinib side effects.
Pregnancy & Lactation Information
FIRST Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

SECOND Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

THIRD Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

Lactation

Caution - Not enough information is available to rule out harm to infants when this drug is taken by nursing mothers.


Learning More About
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Patient Experiences with IMBRUVICA

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