Irinotecan Solution For Injection 20Mg Drug Medication Dosage Information
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Irinotecan: Solution for injection (20mg)

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What is this Medicine?

IRINOTECAN (ir in oh TEE kan ) is a chemotherapy drug. It is used to treat colon and rectal cancer.

In-Depth Information
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Irinotecan Hydrochloride 100mg/5ml Solution for Injection

NDC: 007034434
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved





Sometimes used for but not FDA approved for the following conditions:
Malignant Glioma, Small Cell Lung Cancer (SCLC), Non-small Cell Lung Cancer (NSCLC), Gastric Cancer, Pancreatic Cancer, Glioblastoma Multiforme, Rhabdomyosarcoma

Storage Information
Protect from light
Store in original container
Store between 68 to 77 degrees F, excursions permitted 59 to 86 degrees F
Irinotecan Hydrochloride 100mg/5ml Solution for Injection

Reported Side Effects for Irinotecan Hydrochloride 100mg/5ml Solution for Injection

Exfoliative Dermatitis Incidence:
0.9%*
Severity: SEVERE
Onset: DELAYED
Bleeding Incidence:
1.0-5.0%*
Severity: MODERATE
Onset: EARLY
Infection Incidence:
1.0-14.0%*
Severity: MILD
Onset: DELAYED
Confusion Incidence:
2.7%*
Severity: MODERATE
Onset: EARLY
Anemia Incidence:
4.5-7.0%*
Severity: SEVERE
Onset: DELAYED
Blood Clot Incidence:
5.4%*
Severity: SEVERE
Onset: DELAYED
Low Blood Pressure Incidence:
5.8%*
Severity: MODERATE
Onset: RAPID
Loose Stools Incidence:
6.7-31.0%*
Severity: SEVERE
Onset: EARLY
Flushing Incidence:
9.0-11.0%*
Severity: MILD
Onset: RAPID
Drowsiness Incidence:
9.4%*
Severity: MILD
Onset: EARLY
Upset Stomach Incidence:
10.0%*
Severity: MILD
Onset: EARLY
Elevated Hepatic Enzymes Incidence:
10.0%*
Severity: MODERATE
Onset: DELAYED
Swelling Incidence:
10.0%*
Severity: MODERATE
Onset: DELAYED
Hand And Foot Syndrome Incidence:
10.3%*
Severity: MODERATE
Onset: DELAYED
Mouth Ulcers Incidence:
12.0-29.6%*
Severity: MODERATE
Onset: DELAYED
Gas Incidence:
12.0%*
Severity: MILD
Onset: EARLY
Skin Rash Incidence:
13.0-14.3%*
Severity: MILD
Onset: EARLY
Low White Blood Cells Incidence:
14.0-31.4%*
Severity: SEVERE
Onset: DELAYED
Chills Incidence:
14.0%*
Severity: MILD
Onset: RAPID
Back Pain Incidence:
14.0%*
Severity: MILD
Onset: DELAYED
Lightheadedness Incidence:
15.0-21.1%*
Severity: MILD
Onset: EARLY
Dehydration Incidence:
15.0%*
Severity: MODERATE
Onset: DELAYED
Rhinitis Incidence:
16.0%*
Severity: MILD
Onset: EARLY
Cough Incidence:
17.0-20.2%*
Severity: MILD
Onset: DELAYED
Headache Incidence:
17.0%*
Severity: MILD
Onset: EARLY
Inability To Sleep Incidence:
19.0%*
Severity: MILD
Onset: EARLY
Shortness Of Breath Incidence:
22.0%*
Severity: MODERATE
Onset: EARLY
Weight Loss Incidence:
30.0%*
Severity: MILD
Onset: DELAYED
Constipation Incidence:
30.0-32.3%*
Severity: MODERATE
Onset: DELAYED
Fever Incidence:
43.5-45.0%*
Severity: MILD
Onset: EARLY
Decreased Appetite Incidence:
43.9-55.0%*
Severity: MILD
Onset: DELAYED
Hair Loss Incidence:
46.1-72.0%*
Severity: MILD
Onset: DELAYED
Stomach Pain Incidence:
57.0-67.7%*
Severity: MILD
Onset: EARLY
Vomiting Incidence:
62.0-67.0%*
Severity: MILD
Onset: EARLY
Low White Blood Cell Counts Incidence:
63.0-96.4%*
Severity: MODERATE
Onset: DELAYED
Weakness Incidence:
69.1-76.0%*
Severity: MILD
Onset: DELAYED
Upset Stomach Incidence:
70.0-86.0%*
Severity: MILD
Onset: EARLY
High Bilirubin Level Incidence:
83.9%*
Severity: MODERATE
Onset: DELAYED
Low Platelet Count Incidence:
96.0%*
Severity: MODERATE
Onset: DELAYED
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for Irinotecan Hydrochloride 100mg/5ml Solution for Injection

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Major Lifestyle Interaction
Grapefruit juice and Irinotecan Hydrochloride 100mg/5ml Solution for Injection(Irinotecan Hydrochloride)
Grapefruit juice and Irinotecan(Irinotecan Hydrochloride)
Do not take Irinotecan and grapefruit juice together without talking to your health care provider. Taking these drugs together can increase the risk of serious side effects such as severe, persistent or watery diarrhea, signs of infection or bleeding, pinpoint red spots on the skin, black, tarry stools, sore throat, fever, chills, sores in your mouth or throat, unusual sweating, lightheadedness, dizziness, or fainting spells, or unusual tiredness or weakness. Discuss any new or worsening side effects with your health care provider.
Pregnancy & Lactation Information
FIRST Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

SECOND Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

THIRD Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

Lactation

Avoid - This drug is known to cause harm to infants when taken by nursing mothers.


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