Kadcyla Lyophilisate For Solution For Injection 100Mg Drug Medication Dosage Information
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Kadcyla: Lyophilisate for solution for injection (100mg)

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What is this Medicine?

Ado-trastuzumab emtansine (ADD oh traz TOO zuh mab em TAN zine) is a monoclonal antibody combined with chemotherapy. It targets a protein called HER2. This protein is found in some stomach and breast cancers. This medicine can stop cancer cell growth.

In-Depth Information

Kadcyla 100mg Powder for Injection

NDC: 502420088
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Breast Cancer

Storage Information
Store unreconstituted product in refrigerator (36 to 46 degrees F)
Discard product if it contains particulate matter, is cloudy, or discolored
Diluted product if not used immediately can be stored at 36 to 46 degrees F for up to 24 hours
Reconstituted product may be stored refrigerated in its carton at 36 to 46 degrees F for up to 24 hours if not used immediately
Do not freeze
Kadcyla 100mg Powder for Injection

Reported Side Effects for Kadcyla 100mg Powder for Injection

Anaphylactoid Reactions Incidence:
<1.0%*
Severity: SEVERE
Onset: RAPID
Hepatic Encephalopathy Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Acute Lung Injury Incidence:
<1.0%*
Severity: SEVERE
Onset: EARLY
Decreased Appetite Incidence:
<0.7%*
Severity: SEVERE
Onset: DELAYED
Cough Incidence:
0.1-0.2%*
Severity: SEVERE
Onset: DELAYED
Nose Bleed Incidence:
0.2-0.5%*
Severity: SEVERE
Onset: DELAYED
Mouth Ulcers Incidence:
>0.2%*
Severity: SEVERE
Onset: DELAYED
Itching Incidence:
>0.2%*
Severity: SEVERE
Onset: RAPID
Liver Failure Incidence:
0.2%*
Severity: SEVERE
Onset: DELAYED
Fever Incidence:
0.2-0.3%*
Severity: SEVERE
Onset: EARLY
Lightheadedness Incidence:
>0.4%*
Severity: SEVERE
Onset: EARLY
Constipation Incidence:
0.4-0.6%*
Severity: SEVERE
Onset: DELAYED
Inability To Sleep Incidence:
>0.4%*
Severity: SEVERE
Onset: EARLY
Weakness Incidence:
>0.4%*
Severity: SEVERE
Onset: DELAYED
Heart Failure Incidence:
>0.4%*
Severity: SEVERE
Onset: DELAYED
Muscle Pain Incidence:
>0.6%*
Severity: SEVERE
Onset: EARLY
Joint Pain Incidence:
0.6-0.9%*
Severity: SEVERE
Onset: DELAYED
Headache Incidence:
0.6-0.8%*
Severity: SEVERE
Onset: EARLY
Infection Incidence:
>0.6%*
Severity: SEVERE
Onset: DELAYED
Vomiting Incidence:
0.8-0.9%*
Severity: SEVERE
Onset: EARLY
Upset Stomach Incidence:
0.8-1.1%*
Severity: SEVERE
Onset: EARLY
Stomach Pain Incidence:
>0.8%*
Severity: SEVERE
Onset: EARLY
Shortness Of Breath Incidence:
>0.8%*
Severity: SEVERE
Onset: EARLY
Loose Stools Incidence:
1.0-1.6%*
Severity: SEVERE
Onset: EARLY
Lung Inflammation Incidence:
>1.2%*
Severity: MODERATE
Onset: DELAYED
Infusion-related Reactions Incidence:
>1.4%*
Severity: MODERATE
Onset: RAPID
Bleeding Incidence:
1.8%*
Severity: SEVERE
Onset: EARLY
Muscle And/Or Bone Pain Incidence:
>1.8%*
Severity: SEVERE
Onset: EARLY
Low White Blood Cells Incidence:
2.0-4.0%*
Severity: SEVERE
Onset: DELAYED
Nerve Pain Incidence:
2.2-2.4%*
Severity: SEVERE
Onset: DELAYED
Tired Incidence:
2.5-3.2%*
Severity: SEVERE
Onset: EARLY
Low Potassium Levels Incidence:
2.7-3.3%*
Severity: SEVERE
Onset: DELAYED
Anemia Incidence:
2.9-5.0%*
Severity: SEVERE
Onset: DELAYED
Elevated Hepatic Enzymes Incidence:
3.1-8.0%*
Severity: SEVERE
Onset: DELAYED
Secretion Of Tears Incidence:
>3.3%*
Severity: MILD
Onset: EARLY
Conjunctivitis Incidence:
>3.9%*
Severity: MODERATE
Onset: DELAYED
High Blood Pressure Incidence:
>3.9%*
Severity: MODERATE
Onset: EARLY
Dry Eyes Incidence:
>3.9%*
Severity: MILD
Onset: EARLY
Blurred Vision Incidence:
>4.5%*
Severity: MODERATE
Onset: EARLY
Fluid Retention Incidence:
>7.1%*
Severity: MODERATE
Onset: DELAYED
Chills Incidence:
>7.6%*
Severity: MILD
Onset: RAPID
Metallic Taste Incidence:
>8.0%*
Severity: MILD
Onset: EARLY
Metallic Taste Incidence:
>8.0%*
Severity: MILD
Onset: EARLY
Upset Stomach Incidence:
>9.2%*
Severity: MILD
Onset: EARLY
Skin Rash Incidence:
>11.6%*
Severity: MILD
Onset: EARLY
Low Platelet Count Incidence:
11.9-17.0%*
Severity: SEVERE
Onset: DELAYED
Dry Mouth Incidence:
>16.7%*
Severity: MILD
Onset: EARLY
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Pregnancy & Lactation Information
FIRST Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

SECOND Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

THIRD Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

Lactation

Avoid - This drug is known to cause harm to infants when taken by nursing mothers.


Learning More About
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