Mekinist Oral Tablet 0.5Mg Drug Medication Dosage Information
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Mekinist: Oral tablet (0.5mg)

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What is this Medicine?

TRAMETINIB (tra me ti nib) is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat certain types of melanoma, a skin cancer.

In-Depth Information
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Mekinist 0.5mg Tablet

NDC: 000780666
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Malignant Melanoma

Storage Information
Refrigerate (between 36 and 46 degrees F)
Protect from light
Store and dispense in original container
Do not freeze
Protect from moisture
Mekinist 0.5mg Tablet

Reported Side Effects for Mekinist 0.5mg Tablet

Bleeding Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Intestinal Bleeding Incidence:
<6.0%*
Severity: SEVERE
Onset: DELAYED
Blood In The Urine Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Infection Incidence:
<10.0%*
Severity: MILD
Onset: DELAYED
Bleeding In The Brain Incidence:
<1.4%*
Severity: SEVERE
Onset: DELAYED
Fluid Retention Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Long Qt Syndrome Incidence:
<3.8%*
Severity: MODERATE
Onset: RAPID
Breakdown Of Muscle Incidence:
<10.0%*
Severity: SEVERE
Onset: DELAYED
Vaginal Bleeding Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Vomiting Incidence:
<1.1%*
Severity: SEVERE
Onset: EARLY
Drug-Induced Acne Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Blurred Vision Incidence:
<10.0%*
Severity: MODERATE
Onset: EARLY
Lightheadedness Incidence:
<10.8%*
Severity: MILD
Onset: EARLY
Metallic Taste Incidence:
<10.0%*
Severity: MILD
Onset: EARLY
Skin Redness Incidence:
<32.0%*
Severity: MODERATE
Onset: EARLY
Low Lymphocytes Incidence:
<8.0%*
Severity: SEVERE
Onset: DELAYED
Macular Edema Incidence:
<0.2%*
Severity: SEVERE
Onset: DELAYED
Rash With Pustules Incidence:
<32.0%*
Severity: MILD
Onset: EARLY
Melena Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Bleeding Within The Eye Incidence:
<13.0%*
Severity: SEVERE
Onset: DELAYED
Mouth Sores Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Blood Clot Incidence:
<2.8%*
Severity: SEVERE
Onset: DELAYED
Blood Clot Incidence:
<2.8%*
Severity: SEVERE
Onset: DELAYED
Vesicular Rash Incidence:
<32.0%*
Severity: MILD
Onset: DELAYED
Visual Impairment Incidence:
<0.2%*
Severity: SEVERE
Onset: EARLY
Upset Stomach Incidence:
<0.4%*
Severity: SEVERE
Onset: EARLY
Inflamed Hair Follicles Incidence:
<10.0%*
Severity: MILD
Onset: DELAYED
Nose Bleed Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Heart Failure Incidence:
<11.0%*
Severity: SEVERE
Onset: DELAYED
Swelling Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Hemorrhoids Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Low Blood Sodium Levels Incidence:
<8.0%*
Severity: SEVERE
Onset: DELAYED
Low White Blood Cells Incidence:
<7.0%*
Severity: SEVERE
Onset: DELAYED
Loose Stools Incidence:
<1.3%*
Severity: SEVERE
Onset: EARLY
Itching Incidence:
<2.0%*
Severity: SEVERE
Onset: RAPID
Blood Clot In Lung Incidence:
<2.8%*
Severity: SEVERE
Onset: DELAYED
Low Platelet Count Incidence:
<0.7%*
Severity: SEVERE
Onset: DELAYED
Dry Eyes Incidence:
<10.0%*
Severity: MILD
Onset: EARLY
Dry Skin Incidence:
<11.0%*
Severity: MILD
Onset: DELAYED
Dry Mouth Incidence:
<11.0%*
Severity: MILD
Onset: EARLY
Slow Heart Beat Incidence:
<10.0%*
Severity: SEVERE
Onset: RAPID
Secondary Malignancy Incidence:
0.5-3.3%*
Severity: MODERATE
Onset: DELAYED
Chills Incidence:
0.5%*
Severity: SEVERE
Onset: RAPID
Kidney Failure Incidence:
0.5%*
Severity: SEVERE
Onset: DELAYED
Fainting Incidence:
0.7%*
Severity: MILD
Onset: EARLY
Bruises Incidence:
>1.0%*
Severity: MILD
Onset: DELAYED
Bruise Incidence:
>1.0%*
Severity: MODERATE
Onset: EARLY
Lung Inflammation Incidence:
1.0-2.4%*
Severity: MODERATE
Onset: DELAYED
Stomach Pain Incidence:
1.0-1.9%*
Severity: SEVERE
Onset: EARLY
Skin Rash Incidence:
1.1-8.0%*
Severity: SEVERE
Onset: EARLY
Low Albumin In Blood Incidence:
1.1-2.0%*
Severity: SEVERE
Onset: DELAYED
Dehydration Incidence:
1.8%*
Severity: MODERATE
Onset: DELAYED
Elevated Hepatic Enzymes Incidence:
2.0-4.5%*
Severity: SEVERE
Onset: DELAYED
Mouth Ulcers Incidence:
2.0%*
Severity: SEVERE
Onset: DELAYED
Anemia Incidence:
2.0-2.3%*
Severity: SEVERE
Onset: DELAYED
Increased Blood Sugar Incidence:
4.7%*
Severity: SEVERE
Onset: DELAYED
Fever Incidence:
5.0%*
Severity: SEVERE
Onset: EARLY
Heart Muscle Disease Incidence:
6.0-11.0%*
Severity: SEVERE
Onset: DELAYED
Decreased Appetite Incidence:
9.0-21.0%*
Severity: MILD
Onset: DELAYED
High Blood Pressure Incidence:
11.0-12.0%*
Severity: SEVERE
Onset: EARLY
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Pregnancy & Lactation Information
FIRST Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

SECOND Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

THIRD Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

Lactation

Avoid - This drug is known to cause harm to infants when taken by nursing mothers.


Learning More About
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