Orinase Oral Tablet 500Mg Drug Medication Dosage Information
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Orinase: Oral tablet (500mg)

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Drug Image file DrugItem_2798.JPG
Tolbutamide 500mg Tab
Mylan Institutional LLC
Pill Identification: M 13 
Drug Image file DrugItem_5982.JPG
Orinase 500mg Tab
Pfizer Inc.
Pill Identification: ORINASE 500 
Drug Image file DrugItem_595.JPG
Tolbutamide 500mg Tab
Mylan Pharmaceuticals Inc.
Pill Identification: M 13 

What is this Medicine?

TOLBUTAMIDE (tole BYOO ta mide) helps to treat type 2 diabetes. Treatment is combined with diet and exercise. This drug helps your body to use insulin better.

Similar Generic Drugs : Tolbutamide: Oral tablet (500mg)
In-Depth Information

Orinase 500mg Tablet

NDC: 000090100
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Type 2 Diabetes Mellitus

Orinase 500mg Tablet
Drug Image file DrugItem_5982.JPG
Pfizer Inc.
Pill Identification: ORINASE 500 
Shape: round
Color: white

Reported Side Effects for Orinase 500mg Tablet

Photosensitivity Incidence:
<1.0%*
Severity: MILD
Onset: DELAYED
Pancytopenia Incidence:
<0.1%*
Severity: SEVERE
Onset: DELAYED
Liver Failure Incidence:
<0.1%*
Severity: SEVERE
Onset: DELAYED
Hemolysis Incidence:
<0.1%*
Severity: MODERATE
Onset: EARLY
Elevated Hepatic Enzymes Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Inflamed Blood Vessels Incidence:
<0.1%*
Severity: SEVERE
Onset: DELAYED
Low White Blood Cell Counts Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
Yellow Skin Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Liver Infection Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Cholestasis Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
No White Blood Cells Incidence:
<0.1%*
Severity: SEVERE
Onset: DELAYED
Angioedema Incidence:
<0.1%*
Severity: SEVERE
Onset: RAPID
Low Platelet Count Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
SIADH Incidence:
<0.1%*
Severity: SEVERE
Onset: DELAYED
Aplastic Anemia Incidence:
<0.1%*
Severity: SEVERE
Onset: DELAYED
Joint Pain Incidence:
<0.1%*
Severity: MILD
Onset: DELAYED
Muscle Pain Incidence:
<0.1%*
Severity: MILD
Onset: EARLY
Low Blood Sodium Levels Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
Hemolytic Anemia Incidence:
<0.1%*
Severity: SEVERE
Onset: DELAYED
Metallic Taste Incidence:
1.0-10.0%*
Severity: MILD
Onset: EARLY
Headache Incidence:
1.0-10.0%*
Severity: MILD
Onset: EARLY
Rash With Pustules Incidence:
1.1%*
Severity: MILD
Onset: EARLY
Skin Redness Incidence:
1.1%*
Severity: MODERATE
Onset: EARLY
Itching Incidence:
1.1%*
Severity: MILD
Onset: RAPID
Hives Incidence:
1.1%*
Severity: MILD
Onset: RAPID
Heartburn Incidence:
1.4%*
Severity: MILD
Onset: EARLY
Upset Stomach Incidence:
1.4%*
Severity: MILD
Onset: EARLY
Low Blood Sugar Incidence:
1.8-39.0%*
Severity: MODERATE
Onset: EARLY
Secondary Failure Incidence:
>10.0%*
Severity: SEVERE
Onset: DELAYED
Weight Gain Incidence:
>10.0%*
Severity: MILD
Onset: DELAYED
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for Orinase 500mg Tablet

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Moderate Lifestyle Interaction
Alcohol and Orinase 500mg Tablet(Tolbutamide)
Alcohol and Sulfonylureas(Tolbutamide)
Alcohol may interfere with the actions of Antidiabetic agents (Insulin or other drugs used to treat Diabetes). Alcoholic beverages can increase the risk of low blood sugar, or can cause increased blood sugar due to the calories in these beverages. Limit alcohol containing medicines and beverages if you are on Antidiabetic Agents. You should also learn how to recognize the signs of low blood sugar.
Minor Lifestyle Interaction
Tobacco and Orinase 500mg Tablet(Tolbutamide)
Tobacco and Sulfonylureas(Tolbutamide)
If you use tobacco or are trying to quit tobacco use, you may need to monitor your blood sugar more frequently. Nicotine, a component of tobacco, can increase the blood sugar. Also, if you are trying to quit smoking, as your body adjusts to not smoking, your blood sugar levels may change; the actions of Antidiabetic Agents (medicines used to treat diabetes) may be increased and this could lead to low blood sugar. Know the symptoms of low or high blood sugar and report them if they occur. Monitor your blood sugar regularly.
Pregnancy & Lactation Information
FIRST Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

SECOND Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

THIRD Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

Lactation

Caution - Not enough information is available to rule out harm to infants when this drug is taken by nursing mothers.


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