What is this medicine?
DAUNORUBICIN (daw noe ROO bi sin) is a chemotherapy drug. This medicine is used to treat acute leukemias.
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What should I tell my health care provider before I take this medicine?
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They need to know if you have any of these conditions:
-blood disorders
-heart disease
-infection (especially a virus infection such as chickenpox, cold sores, or herpes)
-kidney disease
-liver disease
-recent or ongoing radiation therapy
-an unusual or allergic reaction to daunorubicin, other chemotherapy agents, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding
How should I use this medicine?
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This drug is given as an infusion into a vein. It is administered in a hospital or clinic by a specially trained health care professional. If you have pain, swelling, burning or any unusual feeling around the site of your injection, tell your health care professional right away.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What if I miss a dose?
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It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.
What may interact with this medicine?
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Do not take this medicine with any of the following medications:
-chloroquine
-cisapride
-droperidol
-halofantrine
-pimozide
This medicine may also interact with the following medications:
-chlorpromazine
-clarithromycin
-cyclophosphamide
-cyclosporine
-erythromycin
-medicines for depression, anxiety, or psychotic disturbances
-medicines for irregular heart beat like amiodarone, bepridil, dofetilide, encainide, flecainide, propafenone, quinidine
-medicines for nausea, vomiting like dolasetron, ondansetron, palonosetron
-medicines to increase blood counts like filgrastim, pegfilgrastim, sargramostim
-methadone
-methotrexate
-pentamidine
-vaccines
Talk to your doctor or health care professional before taking any of these medicines:
-acetaminophen
-aspirin
-ibuprofen
-ketoprofen
-naproxen
What should I watch for while using this medicine?
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Your condition will be monitored carefully while you are receiving this medicine. You will need important blood work done while you are taking this medicine.
This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.
You urine may turn red for a few days after your dose. This is not blood. If your urine is dark or brown, call your doctor.
In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.
This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.
Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.
Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.
Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.
Men may have a lower sperm count while taking this medicine. Talk to your doctor if you plan to father a child.
What side effects may I notice from receiving this medicine?
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Side effects that you should report to your doctor or health care professional as soon as possible:
-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-low blood counts - this medicine may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk for infections and bleeding.
-signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine
-signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine
-signs of decreased red blood cells - unusually weak or tired, fainting spells, lightheadedness
-breathing problems
-chest pain
-gout pain
-fast, irregular heartbeat
-mouth sores
-pain, swelling, redness at site where injected
-swelling of ankles, feet, or hands
-unusual bleeding or bruising
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
-diarrhea
-hair loss
-loss of appetite
-nausea, vomiting
-red colored urine
-stomach upset
Where should I keep my medicine?
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This drug is given in a hospital or clinic and will not be stored at home.
Information on use before, during and after pregnancy.
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FIRST Trimester
Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.
SECOND Trimester
Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.
THIRD Trimester
Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.
Lactation
Avoid - This drug is known to cause harm to infants when taken by nursing mothers.
