Promethazine Information - Side Effects, Drug Interactions, Conditions
show timeout overlay link

Your Session Is About to Expire

This online session is about to expire due to inactivity. Click Continue to return to page.

Promethazine

Also see:
  • Get answers to Frequently Asked Questions (FAQs)
  • Find other class related drugs
  • Find additional patient usage statistics

Most Commonly Used
Drug Image file DrugItem_9737.JPG
Promethazine 12.5mg Tab
Qualitest Pharmaceuticals Inc
Pill Identification: V  |  51 38
Drug Image file default-drug-image.png
Promethazine 25mg Rectal Supp
Drug Image file DrugItem_11018.JPG
Promethazine 25mg Tab
Sandoz Inc
Pill Identification: GG 225 
Drug Image file default-drug-image.png
Promethazine 6.25mg/5ml Soln
Drug Image file DrugItem_13735.JPG
Promethazine 25mg Tab
Qualitest Pharmaceuticals Inc
Pill Identification: V  |  51 37
Overview Information on Promethazine
Pharmacist Tip
Don't drink alcohol while taking promethazine. It can make side effects worse.     
Promethazine is in a class of medicines called phenothiazines. Doctors prescribe promethazine for a variety of medical conditions. Promethazine can be used to treat hay fever and allergy symptoms, such as runny nose, sneezing, itchy or watery eyes, and itching. Promethazine is also used to prevent and treat nausea and vomiting, motion sickness, and dizziness. And doctors sometimes use promethazine to relax patients and prevent nausea before or during surgery and labor.

Promethazine comes as the brand names Phenadoz® and Phenergan®. Your doctor may have prescribed promethazine for you as a tablet, liquid, or rectal suppository form to treat your symptoms. Your doctor will tell you how much to take and how often. It is important to carefully follow your doctor's instructions for taking promethazine. Never take more promethazine than prescribed. Do not take extra promethazine to make up for a missed dose.

Tell your doctor if you have ever had a bad reaction to any medicine, including medicines similar to promethazine.

Promethazine is not for everyone. Promethazine should not be given to children younger than 2 years. It is not known whether promethazine is harmful to take during pregnancy or if you are breast-feeding. Tell your doctor if you are pregnant or breast-feeding, or if you plan to become pregnant while taking promethazine. If you do become pregnant while on promethazine, notify your doctor right away.

Tell your doctor about all your medical conditions. Your doctor will decide whether promethazine is right to treat your symptoms.

Before you take promethazine, your doctor will want to know if you have had:
  • An enlarged prostate
  • Seizures
  • Glaucoma
  • Stomach or digestive problems
  • Bladder or urinary issues
  • Lung or breathing problems
  • Sleep apnea
  • Cancer
  • Blood disorder
  • Heart or liver disease
Some medicines have interactions with promethazine. Make sure your doctor knows about all of the medicines you take, including over-the-counter medicines, herbal remedies, vitamins, and supplements. Give your doctor a complete and up-to-date list of all the medicines you take, so that your doctor can let you know if they can be taken with promethazine.

Promethazine may cause side effects. Some common side effects include:
  • Dry mouth
  • Drowsiness or listlessness
  • Trouble sleeping or nightmares
  • Blurred or double vision
  • Mild nausea or vomiting
  • Nervousness or restlessness
  • Stuffy or runny nose
  • Ringing in the ears
Promethazine can cause other side effects that are more serious. Get emergency help right away if you have signs of an allergic reaction that include itching or hives; swelling or tingling in the face, mouth, throat, or hands; chest pain or tightness; or trouble breathing or swallowing.

Other side effects that you should report to your doctor as soon as possible include:
  • Irregular heartbeat, palpitations, or chest pain
  • Muscle or facial twitches
  • Pain or difficulty passing urine
  • Seizures
  • Skin rash
  • Slowed or shallow breathing
  • Unusual bleeding or bruising
  • Yellowing of the eyes or skin
  • Blurred vision
This is not a complete list. Tell your doctor about these or other side effects that may happen while you are taking promethazine. Let your doctor know if any side effects worsen, worry you, or will not go away.


Clinical Review by Jodi Grimm, RPh and Ann Ciemnoczolowski, MS, ELS on May 15, 2013
Promethazine is in a class of medicines called phenothiazines. Doctors prescribe promethazine for a variety of medical conditions. Promethazine can be used to treat hay fever and allergy symptoms, such as runny nose, sneezing, itchy or watery eyes, and itching. Promethazine is also used to prevent and treat nausea and vomiting, motion sickness, and dizziness. And doctors sometimes use promethazine to relax patients and prevent nausea before or during surgery and labor.

Promethazine comes as the brand names Phenadoz® and Phenergan®. Your doctor may have prescribed promethazine for you as a tablet, liquid, or rectal suppository form to treat your symptoms. Your doctor will tell you how much to take and how often. It is important to carefully follow your doctor's instructions for taking promethazine. Never take more promethazine than prescribed. Do not take extra promethazine to make up for a missed dose.

Tell your doctor if you have ever had a bad reaction to any medicine, including medicines similar to promethazine.

Promethazine is not for everyone. Promethazine should not be given to children younger than 2 years. It is not known whether promethazine is harmful to take during pregnancy or if you are breast-feeding. Tell your doctor if you are pregnant or breast-feeding, or if you plan to become pregnant while taking promethazine. If you do become pregnant while on promethazine, notify your doctor right away.

Tell your doctor about all your medical conditions. Your doctor will decide whether promethazine is right to treat your symptoms.

Before you take promethazine, your doctor will want to know if you have had:
  • An enlarged prostate
  • Seizures
  • Glaucoma
  • Stomach or digestive problems
  • Bladder or urinary issues
  • Lung or breathing problems
  • Sleep apnea
  • Cancer
  • Blood disorder
  • Heart or liver disease
Some medicines have interactions with promethazine. Make sure your doctor knows about all of the medicines you take, including over-the-counter medicines, herbal remedies, vitamins, and supplements. Give your doctor a complete and up-to-date list of all the medicines you take, so that your doctor can let you know if they can be taken with promethazine.

Promethazine may cause side effects. Some common side effects include:
  • Dry mouth
  • Drowsiness or listlessness
  • Trouble sleeping or nightmares
  • Blurred or double vision
  • Mild nausea or vomiting
  • Nervousness or restlessness
  • Stuffy or runny nose
  • Ringing in the ears
Promethazine can cause other side effects that are more serious. Get emergency help right away if you have signs of an allergic reaction that include itching or hives; swelling or tingling in the face, mouth, throat, or hands; chest pain or tightness; or trouble breathing or swallowing.

Other side effects that you should report to your doctor as soon as possible include:
  • Irregular heartbeat, palpitations, or chest pain
  • Muscle or facial twitches
  • Pain or difficulty passing urine
  • Seizures
  • Skin rash
  • Slowed or shallow breathing
  • Unusual bleeding or bruising
  • Yellowing of the eyes or skin
  • Blurred vision
This is not a complete list. Tell your doctor about these or other side effects that may happen while you are taking promethazine. Let your doctor know if any side effects worsen, worry you, or will not go away.


Clinical Review by Jodi Grimm, RPh and Ann Ciemnoczolowski, MS, ELS on May 15, 2013

CVS Patient Statistics for Promethazine
Usage by Age
8.39%
under20_base
26.32%
20to40_base
39.36%
40to60_base
25.93%
over60_base
Most Commonly Used By CVS Patients
Usage by Gender
female_fill_graph
77.89%
female_fill_graph
male_fill_graph
22.11%
male_fill_graph
Learn More About Promethazine
Select a specific form of this drug to visit the summary page where you can:
  • Get answers to Frequently Asked Questions (FAQs)
  • Find other class related drugs
  • Find additional patient usage statistics
Select a Form

Patient Experiences with Promethazine

We want to help you stay educated about the medications you are taking. View other
patient's observations and share your own.

Be sure to consult your health care provider before taking any medications. Other
patient's comments should not be considered medical advice or health care provider
recommendations.