Rapamune Oral Tablet 0.5Mg Drug Medication Dosage Information
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Rapamune: Oral tablet (0.5mg)

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Rapamune 0.5mg Tab
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Rapamune 0.5mg Tab

What is this Medicine?

SIROLIMUS (sir OH li mus) is used to decrease the immune system's response to a transplanted organ.

CVS Pharmacy Patient Statistics for Rapamune: Oral tablet(0.5mg)
Generic vs. Brand Name Usage*
*Brand contains same active ingredient but may not represent FDA-approved generic equivalent
Usage By Strength
In-Depth Information

Rapamune 0.5mg Tablet

NDC: 000081040
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Kidney Transplant Rejection Prophylaxis, Lymphangioleiomyomatosis

Sometimes used for but not FDA approved for the following conditions:
Heart Transplant Rejection Prophylaxis

Storage Information
Store in original package until time of use
Protect from light
Store at controlled room temperature (between 68 and 77 degrees F)
Rapamune 0.5mg Tablet

Reported Side Effects for Rapamune 0.5mg Tablet

Infection Incidence:
<33.0%*
Severity: MILD
Onset: DELAYED
Inflamed Pancreas Incidence:
<3.0%*
Severity: SEVERE
Onset: DELAYED
Secondary Malignancy Incidence:
1.0-10.0%*
Severity: MODERATE
Onset: DELAYED
Post-transplant Lymphoproliferative Disorder (PTLD) Incidence:
1.0-10.0%*
Severity: SEVERE
Onset: DELAYED
Blood Clot Incidence:
3.0-19.9%*
Severity: SEVERE
Onset: DELAYED
Low White Blood Cell Counts Incidence:
3.0-19.9%*
Severity: MODERATE
Onset: DELAYED
Moschcowitz Syndrome Incidence:
3.0-19.9%*
Severity: SEVERE
Onset: DELAYED
Blood Clot Incidence:
3.0-19.9%*
Severity: SEVERE
Onset: DELAYED
Hemolytic-uremic Syndrome Incidence:
3.0-19.9%*
Severity: SEVERE
Onset: DELAYED
No Menstrual Periods Incidence:
3.0-19.9%*
Severity: MILD
Onset: DELAYED
Diabetes Incidence:
3.0-19.0%*
Severity: MODERATE
Onset: DELAYED
Heavy Menstrual Period Incidence:
3.0-19.9%*
Severity: MILD
Onset: DELAYED
Cyst Of Lymph Fluid Incidence:
3.0-19.9%*
Severity: MODERATE
Onset: DELAYED
Low Potassium Levels Incidence:
3.0-19.9%*
Severity: MODERATE
Onset: DELAYED
Decreased Healing Incidence:
3.0-19.9%*
Severity: MODERATE
Onset: DELAYED
Nose Bleed Incidence:
3.0-19.9%*
Severity: MILD
Onset: DELAYED
Blood Clot In Lung Incidence:
3.0-19.9%*
Severity: SEVERE
Onset: DELAYED
Rapid Heart Rate Incidence:
3.0-19.9%*
Severity: MODERATE
Onset: RAPID
Itching Incidence:
>10.0%*
Severity: MILD
Onset: RAPID
Increased Blood Fats Incidence:
>10.0%*
Severity: MODERATE
Onset: DELAYED
Skin Rash Incidence:
10.0-20.0%*
Severity: MILD
Onset: EARLY
Inflamed Hair Follicles Incidence:
>10.0%*
Severity: MILD
Onset: DELAYED
Gum Inflammation Incidence:
>10.0%*
Severity: MILD
Onset: DELAYED
Mouth Sores Incidence:
>10.0%*
Severity: MODERATE
Onset: DELAYED
Onycholysis Incidence:
>10.0%*
Severity: MILD
Onset: DELAYED
Ambras Syndrome Incidence:
>10.0%*
Severity: MILD
Onset: DELAYED
Drug-Induced Acne Incidence:
>10.0%*
Severity: MILD
Onset: DELAYED
Dry Skin Incidence:
>10.0%*
Severity: MILD
Onset: DELAYED
Hair Loss Incidence:
>10.0%*
Severity: MILD
Onset: DELAYED
Low Platelet Count Incidence:
14.0-30.0%*
Severity: MODERATE
Onset: DELAYED
Swelling Incidence:
18.0-20.0%*
Severity: MODERATE
Onset: DELAYED
Acne Incidence:
>20.0%*
Severity: MILD
Onset: DELAYED
Upset Stomach Incidence:
>20.0%*
Severity: MILD
Onset: EARLY
Loose Stools Incidence:
>20.0%*
Severity: MILD
Onset: EARLY
Headache Incidence:
>20.0%*
Severity: MILD
Onset: EARLY
High Cholesterol Incidence:
>20.0%*
Severity: MODERATE
Onset: DELAYED
Muscle Pain Incidence:
>20.0%*
Severity: MILD
Onset: EARLY
Sore Throat Incidence:
>20.0%*
Severity: MILD
Onset: DELAYED
Mouth Ulcers Incidence:
>20.0%*
Severity: MODERATE
Onset: DELAYED
Stomach Pain Incidence:
>20.0%*
Severity: MILD
Onset: EARLY
Fluid Retention Incidence:
>20.0%*
Severity: MODERATE
Onset: DELAYED
Lightheadedness Incidence:
>20.0%*
Severity: MILD
Onset: EARLY
Chest Pain Incidence:
>20.0%*
Severity: MODERATE
Onset: EARLY
Fever Incidence:
23.0-34.0%*
Severity: MILD
Onset: EARLY
Anemia Incidence:
23.0-33.0%*
Severity: MODERATE
Onset: DELAYED
Joint Pain Incidence:
25.0-31.0%*
Severity: MILD
Onset: DELAYED
Constipation Incidence:
36.0-38.0%*
Severity: MODERATE
Onset: DELAYED
High Triglycerides Incidence:
45.0-57.0%*
Severity: MODERATE
Onset: DELAYED
High Blood Pressure Incidence:
45.0-49.0%*
Severity: MODERATE
Onset: EARLY
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for Rapamune 0.5mg Tablet

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Severe Lifestyle Interaction
Grapefruit juice and Rapamune 0.5mg Tablet(Sirolimus)
Grapefruit juice and Sirolimus(Sirolimus)
Avoid Grapefruit Juice while taking Sirolimus. Grapefruits and Grapefruit juice may increase Sirolimus blood levels significantly leading to side effects like abdominal pain, confusion, decreased urination, dizziness, headache, mood changes, nausea-vomiting, tremor, yellowing of skin or eyes, weakness, or other problems.
Major Lifestyle Interaction
High Fat Foods and Rapamune 0.5mg Tablet(Sirolimus)
High Fat Foods and Sirolimus(Sirolimus)
Sirolimus may be taken with or without food, but it is critical that you always take sirolimus consistently with or without food to maintain consistent blood levels of this drug. Avoid grapefruit while taking Sirolimus as grapefruits or grapefruit juice can increase sirolimus concentrations, causing side effects.
Pregnancy & Lactation Information
FIRST Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

SECOND Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

THIRD Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

Lactation

Avoid - This drug is known to cause harm to infants when taken by nursing mothers.


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