Stivarga Oral Tablet 40Mg Drug Medication Dosage Information
show timeout overlay link

Your Session Is About to Expire

This online session is about to expire due to inactivity. Click Continue to return to page.

  • Weekly Ad

Stivarga: Oral tablet (40mg)

Also see:
  • Get answers to Frequently Asked Questions (FAQs)
  • Find other class related drugs
  • Find additional patient usage statistics

Visit Drug Summary Page
Drug Image file default-drug-image.png


What is this Medicine?

REGORAFENIB (RE goe RAF e nib) is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat colorectal cancer, gastrointestinal stromal tumors (GIST), and liver cancer.

In-Depth Information

Stivarga 40mg Tablet

NDC: 504190171
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Colorectal Cancer, Gastrointestinal Stromal Tumors (GIST)

Storage Information
Store in original container
Use within 7 weeks of first opening the bottle
Protect from moisture
Store at 77 degrees F; excursions permitted to 59-86 degrees F
Stivarga 40mg Tablet

Reported Side Effects for Stivarga 40mg Tablet

Weight Loss Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Brain Deterioration Incidence:
<0.1%*
Severity: SEVERE
Onset: DELAYED
Secondary Malignancy Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
Vomiting Incidence:
<1.0%*
Severity: SEVERE
Onset: EARLY
Intestinal Bleeding Incidence:
<21.0%*
Severity: SEVERE
Onset: DELAYED
Protein In The Urine Incidence:
<3.0%*
Severity: SEVERE
Onset: DELAYED
Headache Incidence:
<1.0%*
Severity: SEVERE
Onset: EARLY
Fever Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Hair Loss Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Decreased Appetite Incidence:
<5.0%*
Severity: SEVERE
Onset: DELAYED
Lyell'S Syndrome Incidence:
0.2%*
Severity: SEVERE
Onset: DELAYED
Stevens-Johnson Syndrome Incidence:
0.2%*
Severity: SEVERE
Onset: DELAYED
Erythema Multiforme Incidence:
0.2%*
Severity: SEVERE
Onset: DELAYED
High Blood Pressure Incidence:
0.3%*
Severity: SEVERE
Onset: EARLY
Stomach Abnormality Incidence:
0.6%*
Severity: SEVERE
Onset: DELAYED
Hole In Intestines Incidence:
0.6%*
Severity: SEVERE
Onset: DELAYED
Liver Failure Incidence:
0.8-1.6%*
Severity: SEVERE
Onset: DELAYED
Low White Blood Cells Incidence:
1.0-2.0%*
Severity: SEVERE
Onset: DELAYED
Low Platelet Count Incidence:
1.0-3.0%*
Severity: SEVERE
Onset: DELAYED
Heart Attack Incidence:
1.2%*
Severity: SEVERE
Onset: DELAYED
Heartburn Incidence:
1.4%*
Severity: MILD
Onset: DELAYED
Upset Stomach Incidence:
2.0%*
Severity: SEVERE
Onset: EARLY
Bleeding Incidence:
2.0-4.0%*
Severity: SEVERE
Onset: EARLY
Low Calcium Levels Incidence:
2.0%*
Severity: SEVERE
Onset: DELAYED
Shaking Incidence:
2.0%*
Severity: MILD
Onset: EARLY
Low Potassium Levels Incidence:
3.0-4.0%*
Severity: SEVERE
Onset: DELAYED
High Amylase Levels Incidence:
3.0%*
Severity: SEVERE
Onset: DELAYED
High Bilirubin Level Incidence:
4.0-13.0%*
Severity: SEVERE
Onset: DELAYED
Prolonged Bleeding Time Incidence:
4.0%*
Severity: SEVERE
Onset: DELAYED
Elevated Hepatic Enzymes Incidence:
4.0-6.0%*
Severity: SEVERE
Onset: DELAYED
Weakness Incidence:
4.0-15.0%*
Severity: SEVERE
Onset: DELAYED
Tired Incidence:
4.0-15.0%*
Severity: SEVERE
Onset: EARLY
Underactive Thyroid Incidence:
4.2-18.0%*
Severity: MODERATE
Onset: DELAYED
Dry Mouth Incidence:
4.8%*
Severity: MILD
Onset: EARLY
Infection Incidence:
5.0-9.0%*
Severity: SEVERE
Onset: DELAYED
Anemia Incidence:
6.0%*
Severity: SEVERE
Onset: DELAYED
Skin Rash Incidence:
6.0-7.0%*
Severity: SEVERE
Onset: EARLY
Metallic Taste Incidence:
7.6%*
Severity: MILD
Onset: EARLY
Low Blood Sodium Levels Incidence:
8.0%*
Severity: SEVERE
Onset: DELAYED
Low Lymphocytes Incidence:
8.0-9.0%*
Severity: SEVERE
Onset: DELAYED
Loose Stools Incidence:
8.0%*
Severity: SEVERE
Onset: EARLY
High Blood Pressure Incidence:
8.0-28.0%*
Severity: SEVERE
Onset: EARLY
Hand And Foot Syndrome Incidence:
17.0-22.0%*
Severity: SEVERE
Onset: DELAYED
Low Phosphate Level Incidence:
22.0-32.0%*
Severity: SEVERE
Onset: DELAYED
Hoarseness Incidence:
30.0-39.0%*
Severity: MODERATE
Onset: DELAYED
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for Stivarga 40mg Tablet

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Major Lifestyle Interaction
Grapefruit juice and Stivarga 40mg Tablet(Regorafenib)
Grapefruit juice and Regorafenib(Regorafenib)
Do not take these drugs together without talking to your health care professional. Taking these drugs together may result in altered levels of regorafenib in your body.
Pregnancy & Lactation Information
FIRST Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

SECOND Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

THIRD Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

Lactation

Avoid - This drug is known to cause harm to infants when taken by nursing mothers.


Learning More About
Visit the Drug Summary page where you can:
  • Get answers to Frequently Asked Questions (FAQs)
  • Find other class related drugs
  • Find additional patient usage statistics
Learn More
Patient Experiences with Stivarga

Be the first to share your experience!

We want to help our customers stay educated about the medications they are taking. Submit your own observations and experiences to benefit others.

Average Scores
Easy to Take 
0 / 5
0 / 5
Works as Intended 
0 / 5
0 / 5
Tolerable 
0 / 5
0 / 5