Symbyax Oral Capsule 12-25Mg Drug Medication Dosage Information
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Symbyax: Oral capsule (12-25mg)

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Drug Image file DrugItem_5695.JPG
Symbyax 12mg-25mg Capsule
Eli Lilly and Co
Pill Identification: Lilly 3232 12/25 

What is this Medicine?

FLUOXETINE; OLANZAPINE (floo OX e teen; oh LAN za peen) is used to treat episodes of depression that have not been relieved by the use of other medicines and depression caused by bipolar disorder.

CVS Pharmacy Patient Statistics for Symbyax: Oral capsule(12-25mg)
Generic vs. Brand Name Usage*
*Brand contains same active ingredient but may not represent FDA-approved generic equivalent
Usage By Strength
In-Depth Information

Symbyax 12mg-25mg Capsule

NDC: 000023232
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Bipolar Depression, Depression

Storage Information
Store at room temperature (between 59 to 86 degrees F)
Protect from moisture
Symbyax 12mg-25mg Capsule
Drug Image file DrugItem_5695.JPG
Eli Lilly and Co
Pill Identification: Lilly 3232 12/25 
Shape: capsule
Color: red,yellow

Reported Side Effects for Symbyax 12mg-25mg Capsule

Inflamed Pancreas Incidence:
<0.1%*
Severity: SEVERE
Onset: DELAYED
Low White Blood Cell Counts Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
Intestinal Blockage Incidence:
<0.1%*
Severity: SEVERE
Onset: DELAYED
Intestinal Bleeding Incidence:
<0.1%*
Severity: SEVERE
Onset: DELAYED
Dry Eyes Incidence:
<0.1%*
Severity: MILD
Onset: EARLY
Bruises Incidence:
<0.1%*
Severity: MILD
Onset: DELAYED
Increased Sexual Desire Incidence:
<0.1%*
Severity: MILD
Onset: DELAYED
Vocal Cord Spasm Incidence:
<0.1%*
Severity: SEVERE
Onset: RAPID
Hyperkinesis Incidence:
<0.1%*
Severity: MILD
Onset: DELAYED
Elevated Hepatic Enzymes Incidence:
<9.0%*
Severity: MODERATE
Onset: DELAYED
Dystonic Reaction Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
High Triglycerides Incidence:
<15.1%*
Severity: MODERATE
Onset: DELAYED
Gout Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
High Bilirubin Level Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
Exfoliative Dermatitis Incidence:
<0.1%*
Severity: SEVERE
Onset: DELAYED
Osteoporosis Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
Nose Bleed Incidence:
0.1-1.0%*
Severity: MILD
Onset: DELAYED
Elated Mood Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: EARLY
Emotional Lability Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Inflamed Stomach Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Rapid Muscle Twitches Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Stomach Ulcer Incidence:
0.1-1.0%*
Severity: SEVERE
Onset: DELAYED
Coma Incidence:
0.1-1.0%*
Severity: SEVERE
Onset: EARLY
Withdrawal Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: EARLY
Yawning Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Upset Stomach Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Anemia Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
No Menstrual Periods Incidence:
0.1-1.0%*
Severity: MILD
Onset: DELAYED
Hair Loss Incidence:
0.1-1.0%*
Severity: MILD
Onset: DELAYED
Retaining Urine Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: EARLY
Urinary Urgency Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Dry Skin Incidence:
0.1-1.0%*
Severity: MILD
Onset: DELAYED
Low Platelet Count Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Itching Incidence:
0.1-1.0%*
Severity: MILD
Onset: RAPID
Long Qt Syndrome Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: RAPID
Vomiting Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Incoordination Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Dysarthria Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Metallic Taste Incidence:
>1.0%*
Severity: MILD
Onset: EARLY
Bruise Incidence:
>1.0%*
Severity: MILD
Onset: DELAYED
Increased Urination Incidence:
>1.0%*
Severity: MILD
Onset: EARLY
Uncontrolled Urination Incidence:
>1.0%*
Severity: MODERATE
Onset: EARLY
Irregular Periods Incidence:
>1.0%*
Severity: MILD
Onset: DELAYED
Weight Loss Incidence:
>1.0%*
Severity: MILD
Onset: DELAYED
Loss Of Memory Incidence:
>1.0%*
Severity: MODERATE
Onset: DELAYED
Heavy Menstrual Period Incidence:
>1.0%*
Severity: MILD
Onset: DELAYED
Breast Pain Incidence:
>1.0%*
Severity: MILD
Onset: DELAYED
Photosensitivity Incidence:
>1.0%*
Severity: MILD
Onset: DELAYED
Loose Stools Incidence:
>1.0%*
Severity: MILD
Onset: EARLY
Chills Incidence:
>1.0%*
Severity: MILD
Onset: RAPID
Peripheral Vasodilation Incidence:
>1.0%*
Severity: MODERATE
Onset: RAPID
Increased Blood Sugar Incidence:
1.9-34.1%*
Severity: MODERATE
Onset: DELAYED
Rapid Heart Rate Incidence:
>2.0%*
Severity: MODERATE
Onset: RAPID
Sinus Infection Incidence:
2.0%*
Severity: MILD
Onset: DELAYED
Fever Incidence:
2.0%*
Severity: MILD
Onset: EARLY
Stomach Pain Incidence:
2.0%*
Severity: MILD
Onset: EARLY
Impotence (erectile Dysfunction) Incidence:
2.0%*
Severity: MODERATE
Onset: DELAYED
High Cholesterol Incidence:
2.5-36.2%*
Severity: MODERATE
Onset: DELAYED
Restlessness Incidence:
3.0-4.0%*
Severity: MILD
Onset: EARLY
Muscle And/Or Bone Pain Incidence:
3.0%*
Severity: MILD
Onset: EARLY
Weakness Incidence:
3.0%*
Severity: MILD
Onset: DELAYED
Gas Incidence:
3.0%*
Severity: MILD
Onset: EARLY
Joint Pain Incidence:
4.0%*
Severity: MILD
Onset: DELAYED
Blurred Vision Incidence:
5.0%*
Severity: MODERATE
Onset: EARLY
Shaking Incidence:
9.0%*
Severity: MILD
Onset: EARLY
Tired Incidence:
12.0%*
Severity: MILD
Onset: EARLY
Dry Mouth Incidence:
15.0%*
Severity: MILD
Onset: EARLY
Swelling Incidence:
15.0%*
Severity: MODERATE
Onset: DELAYED
Causing To Be Hungry Incidence:
17.0-20.0%*
Severity: MILD
Onset: DELAYED
Weight Gain Incidence:
20.0-25.0%*
Severity: MILD
Onset: DELAYED
Drowsiness Incidence:
24.0-27.0%*
Severity: MILD
Onset: EARLY
High Prolactin Level Incidence:
>28.0%*
Severity: MODERATE
Onset: DELAYED
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for Symbyax 12mg-25mg Capsule

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Major Lifestyle Interaction
Alcohol and Symbyax 12mg-25mg Capsule(Olanzapine)
Alcohol and CNS Depressants(Olanzapine)
Avoid alcohol-containing drinks while taking this medicine. Using this drug along with alcohol can lead to serious side effects. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery until you know how this drug affects you, and especially if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Moderate Lifestyle Interaction
Marijuana and Symbyax 12mg-25mg Capsule(Fluoxetine Hydrochloride)
Marijuana and Fluoxetine(Fluoxetine Hydrochloride)
Fluoxetine can theoretically decrease the elimination of Marijuana, Medical from the body. Side effects from Marijuana, Medical may get worse if you take Fluoxetine. You may feel drowsy or more tired. Do not drive or operate machinery until you know how these drugs affect you. Contact your health care provider immediately if you notice slurred speech, confusion, increases heart rate, or palpitations while taking Marijuana, Medical.
Moderate Lifestyle Interaction
Tobacco and Symbyax 12mg-25mg Capsule(Olanzapine)
Tobacco and Olanzapine(Olanzapine)
Tobacco smoke may decrease the effectiveness of Olanzapine by increasing the elimination of Olanzapine from the body. If you smoke tobacco, notify your prescriber if you experience changes in mood (like agitation or hearing or seeing things that are not really there) that may indicate that Olanzapine is not working as well for you. If you suddenly stop smoking tobacco, this may increase the actions of Olanzapine; notify your prescriber if you notice increased drowsiness, dizziness or other unusual side effects.
Moderate Lifestyle Interaction
Marijuana and Symbyax 12mg-25mg Capsule(Olanzapine)
Marijuana and Antipsychotics(Olanzapine)
Marijuana smoke may decrease the effectiveness of Antipsychotics by increasing the elimination of Antipsychotic medications from the body. If you smoke Marijuana, Medical, notify your prescriber if you experience changes in mood (like agitation or hearing or seeing things that are not really there) that may indicate your Antipsychotic medication is not working as well for you. If you suddenly stop smoking Marijuana, Medical, this may increase the actions of Antipsychotics; notify your prescriber if you notice increased drowsiness, dizziness or other unusual side effects.
Pregnancy & Lactation Information
FIRST Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

SECOND Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

THIRD Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

Lactation

Caution - Not enough information is available to rule out harm to infants when this drug is taken by nursing mothers.


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