Topotecan Powder For Solution For Injection 4Mg Drug Medication Dosage Information
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Topotecan: Powder for solution for injection (4mg)

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What is this Medicine?

TOPOTECAN (TOE poe TEE kan) is a chemotherapy drug. It is used to treat lung cancer, ovarian cancer, and cervical cancer.

In-Depth Information
Select a Medication

Topotecan Hydrochloride 4mg Powder for Injection

NDC: 000690075
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Cervical Cancer, Ovarian Cancer

Sometimes used for but not FDA approved for the following conditions:
Small Cell Lung Cancer (SCLC), Non-small Cell Lung Cancer (NSCLC), Rhabdomyosarcoma

Storage Information
Reconstituted product should be used immediately. Discard unused portion
Protect from light
Store in carton
Store at controlled room temperature (between 68 and 77 degrees F)
Topotecan Hydrochloride 4mg Powder for Injection

Reported Side Effects for Topotecan Hydrochloride 4mg Powder for Injection

Vomiting Incidence:
<3.4%*
Severity: SEVERE
Onset: EARLY
Anaphylactoid Reactions Incidence:
<1.0%*
Severity: SEVERE
Onset: RAPID
Weakness Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Upset Stomach Incidence:
<3.0%*
Severity: SEVERE
Onset: EARLY
Angioedema Incidence:
<1.0%*
Severity: SEVERE
Onset: RAPID
Decreased Appetite Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
High Bilirubin Level Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Tired Incidence:
<4.1%*
Severity: SEVERE
Onset: EARLY
Hair Loss Incidence:
0.1%*
Severity: SEVERE
Onset: DELAYED
Fever Incidence:
1.0-2.0%*
Severity: SEVERE
Onset: EARLY
Superinfection Incidence:
2.0-5.0%*
Severity: SEVERE
Onset: DELAYED
Loose Stools Incidence:
4.0-5.0%*
Severity: SEVERE
Onset: EARLY
Elevated Hepatic Enzymes Incidence:
4.0%*
Severity: SEVERE
Onset: DELAYED
Intestinal Blockage Incidence:
5.0%*
Severity: SEVERE
Onset: DELAYED
Anemia Incidence:
22.0-42.0%*
Severity: SEVERE
Onset: DELAYED
Low Platelet Count Incidence:
27.0-37.0%*
Severity: SEVERE
Onset: DELAYED
Low White Blood Cells Incidence:
48.0-80.0%*
Severity: SEVERE
Onset: DELAYED
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for Topotecan Hydrochloride 4mg Powder for Injection

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Major Lifestyle Interaction
Grapefruit juice and Topotecan Hydrochloride 4mg Powder for Injection(Topotecan Hydrochloride)
Grapefruit juice and Topotecan Hydrochloride(Topotecan Hydrochloride)
Do not take Topotecan and Grapefruit Juice together without talking with your health care provider. Increased side effects of Topotecan may occur if you also take Grapefruit Juice. Immediately call your prescriber if you experience severe diarrhea; unusual bleeding or bruising; symptoms of an infection such as fever, chills, or sore throat.
Pregnancy & Lactation Information
FIRST Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

SECOND Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

THIRD Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

Lactation

Avoid - This drug is known to cause harm to infants when taken by nursing mothers.


Learning More About
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