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Treanda: Solution for injection (45mg)

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What is this Medicine?

BENDAMUSTINE (BEN da MUS teen) is a chemotherapy drug. It is used to treat chronic lymphocytic leukemia and non-Hodgkin lymphoma.

In-Depth Information

Treanda 45mg/0.5mL Solution for Injection

NDC: 634590395
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Non-Hodgkin's Lymphoma (NHL), Chronic Lymphocytic Leukemia (CLL)

Sometimes used for but not FDA approved for the following conditions:
Mantle Cell Lymphoma (MCL), Acute Lymphocytic Leukemia (ALL)

Storage Information
Refrigerate (between 36 and 46 degrees F)
Use diluted product within 24 hours when stored refrigerated (36 to 46 degrees F) or within 2 hours when stored at room temperature (59 to 86 degrees F)
Store in original package until time of use
Protect from light
Discard product if it contains particulate matter, is cloudy, or discolored
Discard unused portion. Do not store for later use.
Treanda 45mg/0.5mL Solution for Injection

Reported Side Effects for Treanda 45mg/0.5mL Solution for Injection

High Blood Pressure Incidence:
<1.0%*
Severity: MODERATE
Onset: EARLY
Chest Pain Incidence:
<1.0%*
Severity: SEVERE
Onset: EARLY
Weakness Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Anaphylactoid Reactions Incidence:
<1.0%*
Severity: SEVERE
Onset: RAPID
Vomiting Incidence:
<3.0%*
Severity: SEVERE
Onset: EARLY
Stevens-Johnson Syndrome Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Mouth Ulcers Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Fluid Retention Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Dry Mouth Incidence:
<1.0%*
Severity: SEVERE
Onset: EARLY
Upset Stomach Incidence:
<4.0%*
Severity: SEVERE
Onset: EARLY
Weight Loss Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Nervousness Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Lyell'S Syndrome Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Constipation Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Cough Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Loose Stools Incidence:
<3.0%*
Severity: SEVERE
Onset: EARLY
Skin Rash Incidence:
<3.0%*
Severity: SEVERE
Onset: EARLY
Headache Incidence:
<21.0%*
Severity: MILD
Onset: EARLY
High Blood Pressure Incidence:
<1.0%*
Severity: SEVERE
Onset: EARLY
Elevated Hepatic Enzymes Incidence:
1.0-3.0%*
Severity: SEVERE
Onset: DELAYED
Stomach Pain Incidence:
1.0%*
Severity: SEVERE
Onset: EARLY
Low Blood Pressure Incidence:
1.0%*
Severity: SEVERE
Onset: RAPID
Tired Incidence:
1.0-11.0%*
Severity: SEVERE
Onset: EARLY
High Uric Acid Level Incidence:
2.0%*
Severity: SEVERE
Onset: DELAYED
Low Calcium Levels Incidence:
2.0%*
Severity: MODERATE
Onset: DELAYED
Fever Incidence:
2.0-4.0%*
Severity: SEVERE
Onset: EARLY
Low Blood Sodium Levels Incidence:
2.0%*
Severity: MODERATE
Onset: DELAYED
Decreased Appetite Incidence:
2.0%*
Severity: SEVERE
Onset: DELAYED
Shortness Of Breath Incidence:
2.0%*
Severity: SEVERE
Onset: EARLY
Back Pain Incidence:
3.0%*
Severity: SEVERE
Onset: DELAYED
High Bilirubin Level Incidence:
3.0%*
Severity: SEVERE
Onset: DELAYED
Increased Blood Sugar Incidence:
3.0%*
Severity: MODERATE
Onset: DELAYED
Stuffy Nose Incidence:
5.0%*
Severity: MILD
Onset: EARLY
Bone Pain Incidence:
5.0%*
Severity: MODERATE
Onset: DELAYED
Itching Incidence:
5.0-6.0%*
Severity: MILD
Onset: RAPID
Wheezing Incidence:
5.0%*
Severity: MODERATE
Onset: RAPID
Dry Skin Incidence:
5.0%*
Severity: MILD
Onset: DELAYED
Dehydration Incidence:
5.0%*
Severity: SEVERE
Onset: DELAYED
Low Potassium Levels Incidence:
5.0%*
Severity: SEVERE
Onset: DELAYED
Night Sweats Incidence:
5.0%*
Severity: MILD
Onset: EARLY
Excessive Sweating Incidence:
5.0%*
Severity: MILD
Onset: DELAYED
Depression Incidence:
6.0%*
Severity: MODERATE
Onset: DELAYED
Chills Incidence:
6.0-14.0%*
Severity: MILD
Onset: RAPID
Joint Pain Incidence:
6.0%*
Severity: MILD
Onset: DELAYED
Sore Throat Incidence:
6.0-7.0%*
Severity: MILD
Onset: DELAYED
Metallic Taste Incidence:
7.0%*
Severity: MILD
Onset: EARLY
Rapid Heart Rate Incidence:
7.0%*
Severity: MODERATE
Onset: RAPID
Drowsiness Incidence:
>10.0%*
Severity: MILD
Onset: EARLY
Heartburn Incidence:
10.0%*
Severity: MILD
Onset: DELAYED
Infusion-related Reactions Incidence:
>10.0%*
Severity: MODERATE
Onset: RAPID
Upset Stomach Incidence:
11.0%*
Severity: MILD
Onset: EARLY
Low Platelet Count Incidence:
11.0-25.0%*
Severity: SEVERE
Onset: DELAYED
Anemia Incidence:
11.0-13.0%*
Severity: SEVERE
Onset: DELAYED
Inability To Sleep Incidence:
13.0%*
Severity: MILD
Onset: EARLY
Lightheadedness Incidence:
14.0%*
Severity: MILD
Onset: EARLY
Low White Blood Cell Counts Incidence:
28.0-56.0%*
Severity: SEVERE
Onset: DELAYED
Low White Blood Cells Incidence:
43.0-60.0%*
Severity: SEVERE
Onset: DELAYED
Low Lymphocytes Incidence:
47.0-94.0%*
Severity: SEVERE
Onset: DELAYED
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for Treanda 45mg/0.5mL Solution for Injection

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Moderate Lifestyle Interaction
Tobacco and Treanda 45mg/0.5mL Solution for Injection(Bendamustine HCl)
Tobacco and Bendamustine HCl(Bendamustine HCl)
Smoking Tobacco and Bendamustine may interact. Smoking Tobacco may cause a decrease in the effects of Bendamustine. Bendamustine is only used in a hospital or clinic and your health care provider will closely monitor its effects. Tell your doctor if you have been Smoking Tobacco.
Pregnancy & Lactation Information
FIRST Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

SECOND Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

THIRD Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

Lactation

Avoid - This drug is known to cause harm to infants when taken by nursing mothers.


Learning More About
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Patient Experiences with Treanda

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