Vfend Lyophilisate For Solution For Injection 200Mg Drug Medication Dosage Information
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VFEND: Lyophilisate for solution for injection (200mg)

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What is this Medicine?

VORICONAZOLE (vohr ih KON uh zohl) is an antifungal medicine. It is used to treat certain kinds of fungal or yeast infections.

In-Depth Information

Vfend 200mg Powder for Injection

NDC: 000493190
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Peritonitis, Aspergillosis, Pericarditis, Myocarditis, Endocarditis, Infectious Arthritis, Candidiasis, Candidemia, Osteomyelitis, Tracheobronchitis, Fusariosis, Sinusitis, Scedosporiosis

Sometimes used for but not FDA approved for the following conditions:
Febrile Neutropenia, Fungal Keratitis, Meningitis, Esophageal Candidiasis, Endophthalmitis, Penicilliosis

Storage Information
Store at room temperature (between 59 to 86 degrees F)
Store reconstituted product upright in the refrigerator for use within 24 hours
Vfend 200mg Powder for Injection

Reported Side Effects for Vfend 200mg Powder for Injection

Convulsions Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Brain Attack Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Thoughts Of Suicide Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Fainting Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Moschcowitz Syndrome Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Vaginal Bleeding Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Restlessness Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Loss Of Memory Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Anaphylactoid Reactions Incidence:
<2.0%*
Severity: SEVERE
Onset: RAPID
Abnormal Heart Rhythm Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Weakness Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Incoordination Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Low Kidney Function Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Back Pain Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Inflammation Of The Lip Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Chest Pain Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Confusion Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Conjunctivitis Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Corneal Opacification Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Cyanosis Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Double Vision Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Lightheadedness Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Metallic Taste Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Bruise Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Stomach Pain Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
No White Blood Cells Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Inability To Urinate Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Bundle-branch Block Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Cholestasis Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Difficulty Swallowing Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Brain Dysfunction Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Intestinal Bleeding Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Hole In Intestines Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Blood In The Urine Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Liver Infection Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Increased Blood Sugar Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
High Sodium Levels Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Increased Blood Volume Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Infection Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Flu Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Low White Blood Cell Counts Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Muscle Cramps Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Heart Attack Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Muscle Disease Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Inflamed Pancreas Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Optic Disc Swelling Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Fluid Retention Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Nerve Pain Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Psychosis Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Long Qt Syndrome Incidence:
<2.0%*
Severity: MODERATE
Onset: RAPID
Nightmares Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Bleeding Within The Eye Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Optic Atrophy Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Mouth Sores Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Ear Pain Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Rapid Heart Rate Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Pancytopenia Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Paresthesias Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Pelvic Pain Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Stomach Ulcer Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Peripheral Vasodilation Incidence:
<2.0%*
Severity: MODERATE
Onset: RAPID
Red Spotted Rash Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Irritated Blood Vessels Incidence:
<2.0%*
Severity: MODERATE
Onset: RAPID
Photosensitivity Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Pseudoporphyria Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Bruises Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Kidney Damage Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Bleeding In Eye Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Rhinitis Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Skin Discoloration Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Removal Of Spleen Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Rapid Heart Rate Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Testicular Swelling Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Lyell'S Syndrome Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Dead Bone Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Eosinophilia Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Throat Ulcers Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Elated Mood Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Back Pain Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Flushing Incidence:
<2.0%*
Severity: MILD
Onset: RAPID
Gingival Hyperplasia Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Inflamed Tongue Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Glycosuria Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Deafness Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Vomiting Of Blood Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Coughing Up Blood Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Liver Failure Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Enlarged Liver Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Excessive Mucle Tone Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Hypoxia Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Impotence (erectile Dysfunction) Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Injection Site Reaction Incidence:
<2.0%*
Severity: MILD
Onset: RAPID
Decreased Sexual Desire Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Lupus-like Symptoms Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Enlarged Lymph Nodes Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Rash With Pustules Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Melena Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Muscle Weakness Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Large Pupil Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Night Blindness Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Loose Stools Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Disseminated Intravascular Coagulation (DIC) Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Drowsiness Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Menstrual Cramps Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Upset Stomach Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Shortness Of Breath Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Painful Urination Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Eczema Vaccinatum Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Swelling Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Epididymis Inflammation Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Nose Bleed Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Erythema Multiforme Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Throat Inflammation Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Exfoliative Dermatitis Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Gas Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Boils Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Gum Inflammation Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Guillain-Barre Syndrome Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Heart Failure Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Hemolytic Anemia Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Painful Bloody Urine Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
High Calcium Levels Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
High Cholesterol Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
High Potassium Level Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
High Magnesium Level Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Distressed Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Hair Loss Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Anemia Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Angioedema Incidence:
<2.0%*
Severity: SEVERE
Onset: RAPID
Decreased Appetite Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Nervousness Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Aplastic Anemia Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Joint Pain Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Extra Abdominal Fluid Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Irregular Heart Beat Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Heart Block Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Inflamed Eyes Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Bone Pain Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Slow Heart Beat Incidence:
<2.0%*
Severity: SEVERE
Onset: RAPID
Suddenly Stopped Heart Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Heart Muscle Disease Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Swelling Of The Brain Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Cholecystitis Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Gallstones Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Coma Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Constipation Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Allergic Skin Reaction Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Cough Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Delirium Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Depression Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Diabetes Insipidus Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Eye Pain Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Decreased Urination Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Inflamed Optic Nerve Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Postural Low Blood Pressure Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Soft Bones Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Osteoporosis Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Sore Throat Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Retaining Urine Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Fluid Around The Lungs Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Rectal Infection Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Itching Incidence:
<2.0%*
Severity: MILD
Onset: RAPID
Pseudomembranous Colitis Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Psoriasis Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Fluid In Lungs Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Blood Clot In Lung Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Sinus Infection Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Stevens-Johnson Syndrome Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Mouth Ulcers Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Low Platelet Count Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Ringing In Ears Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Torsade De Pointes Incidence:
<2.0%*
Severity: SEVERE
Onset: RAPID
Shaking Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Uncontrolled Urination Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
High Blood Pressure Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Overactive Thyroid Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
High Uric Acid Level Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Low Calcium Levels Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Dry Mouth Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Low Blood Sugar Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Dry Skin Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Dry Eyes Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Balance Problems Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Low Magnesium Levels Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Rapid Heart Rate Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Low Blood Sodium Levels Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Low Phosphate Level Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Low Blood Pressure Incidence:
<2.0%*
Severity: MODERATE
Onset: RAPID
Rapid Heart Rate Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Underactive Thyroid Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Eye Inflammation Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Inability To Sleep Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Eye Inflammatoin Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Inflamed Eye Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Megaloblastic Anemia Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Muscle Pain Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Hives Incidence:
<2.0%*
Severity: MILD
Onset: RAPID
Fast Eye Movements Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Kidney Failure Incidence:
0.4%*
Severity: SEVERE
Onset: DELAYED
Yellow Skin Incidence:
1.0%*
Severity: MODERATE
Onset: DELAYED
Light Sensitivity Incidence:
2.2%*
Severity: MODERATE
Onset: EARLY
Rapid Heart Rate Incidence:
2.4%*
Severity: MODERATE
Onset: RAPID
Hallucinations Incidence:
2.4%*
Severity: MODERATE
Onset: EARLY
Headache Incidence:
3.0%*
Severity: MILD
Onset: EARLY
Chills Incidence:
3.7%*
Severity: MILD
Onset: RAPID
High Bilirubin Level Incidence:
4.3-19.4%*
Severity: MODERATE
Onset: DELAYED
Vomiting Incidence:
4.4%*
Severity: MILD
Onset: EARLY
Skin Rash Incidence:
5.3%*
Severity: MILD
Onset: EARLY
Upset Stomach Incidence:
5.4%*
Severity: MILD
Onset: EARLY
Fever Incidence:
5.7%*
Severity: MILD
Onset: EARLY
Elevated Hepatic Enzymes Incidence:
8.4-20.3%*
Severity: MODERATE
Onset: DELAYED
Low Potassium Levels Incidence:
16.6-16.7%*
Severity: MODERATE
Onset: DELAYED
Visual Impairment Incidence:
18.7%*
Severity: SEVERE
Onset: EARLY
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for Vfend 200mg Powder for Injection

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Moderate Lifestyle Interaction
Marijuana and Vfend 200mg Powder for Injection(Voriconazole)
Marijuana and Voriconazole(Voriconazole)
Voriconazole can theoretically decrease the elimination of Marijuana, Medical from the body. Side effects from Marijuana, Medical may get worse if you take Voriconazole. You may feel drowsy or more tired. Do not drive or operate machinery until you know how these drugs affect you. Contact your health care provider immediately if you notice slurred speech, confusion, increases heart rate, or palpitations while taking Marijuana, Medical.
Minor Lifestyle Interaction
Grapefruit juice and Vfend 200mg Powder for Injection(Voriconazole)
Grapefruit juice and Voriconazole(Voriconazole)
Side effects from Voriconazole may get worse if you drink grapefruit juice. Grapefruit juice may decrease the elimination of Voriconazole from your body. If possible, avoid drinking grapefruit juice while you are taking Voriconazole therapy. You may drink other types of juice, such as orange juice.
Minor Lifestyle Interaction
Food and Vfend 200mg Powder for Injection(Voriconazole)
Food and Voriconazole(Voriconazole)
Take oral voriconazole one hour before or one hour after meals. Food may decrease the amount of voriconazole that is absorbed into your body.
Pregnancy & Lactation Information
FIRST Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

SECOND Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

THIRD Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

Lactation

Avoid - This drug is known to cause harm to infants when taken by nursing mothers.


Learning More About
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