Zelapar Oral Disintegrating Tablet 1.25Mg Drug Medication Dosage Information
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Zelapar: Oral disintegrating tablet (1.25mg)

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What is this Medicine?

SELEGILINE (se LE ji leen) is an monoamine oxidase inhibitor (MAOI). It is used with levodopa-carbidopa in the treatment of Parkinson's disease. It is usually added to therapy when there is a decrease in response to levodopa.

In-Depth Information

Zelapar 1.25mg Orally Disintegrating Tablet

NDC: 001870453
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Parkinson's Disease, Parkinsonism

Sometimes used for but not FDA approved for the following conditions:
Depression, Alzheimer's Disease

Storage Information
Store in original container
Product should be used within 3 months after opening
Store at 77 degrees F; excursions permitted to 59-86 degrees F
Zelapar 1.25mg Orally Disintegrating Tablet

Reported Side Effects for Zelapar 1.25mg Orally Disintegrating Tablet

Skin Redness Incidence:
<3.0%*
Severity: MODERATE
Onset: EARLY
Postural Low Blood Pressure Incidence:
<21.0%*
Severity: MODERATE
Onset: DELAYED
Mouth Sores Incidence:
2.0%*
Severity: MODERATE
Onset: DELAYED
Difficulty Swallowing Incidence:
2.0%*
Severity: MODERATE
Onset: DELAYED
Low Potassium Levels Incidence:
2.0%*
Severity: MODERATE
Onset: DELAYED
Bruise Incidence:
2.0%*
Severity: MILD
Onset: DELAYED
Chest Pain Incidence:
2.0%*
Severity: MODERATE
Onset: EARLY
Gas Incidence:
2.0%*
Severity: MILD
Onset: EARLY
Loose Stools Incidence:
2.0%*
Severity: MILD
Onset: EARLY
Depression Incidence:
2.0%*
Severity: MODERATE
Onset: DELAYED
Vomiting Incidence:
3.0%*
Severity: MILD
Onset: EARLY
Shaking Incidence:
3.0%*
Severity: MILD
Onset: EARLY
Muscle Cramps Incidence:
3.0%*
Severity: MILD
Onset: DELAYED
Shortness Of Breath Incidence:
3.0%*
Severity: MODERATE
Onset: EARLY
Incoordination Incidence:
3.0%*
Severity: MODERATE
Onset: DELAYED
Drowsiness Incidence:
3.0%*
Severity: MILD
Onset: EARLY
High Blood Pressure Incidence:
3.0%*
Severity: MODERATE
Onset: EARLY
Constipation Incidence:
4.0%*
Severity: MODERATE
Onset: DELAYED
Sore Throat Incidence:
4.0%*
Severity: MILD
Onset: DELAYED
Hallucinations Incidence:
4.0-6.1%*
Severity: MODERATE
Onset: EARLY
Skin Rash Incidence:
4.0%*
Severity: MILD
Onset: EARLY
Dry Mouth Incidence:
4.0-6.1%*
Severity: MILD
Onset: EARLY
Headache Incidence:
4.1-7.0%*
Severity: MILD
Onset: EARLY
Upset Stomach Incidence:
5.0%*
Severity: MILD
Onset: EARLY
Back Pain Incidence:
5.0%*
Severity: MILD
Onset: DELAYED
Mouth Ulcers Incidence:
5.0%*
Severity: MODERATE
Onset: DELAYED
Dyskinesia Incidence:
6.0%*
Severity: MODERATE
Onset: DELAYED
Confusion Incidence:
6.1%*
Severity: MODERATE
Onset: EARLY
Rhinitis Incidence:
7.0%*
Severity: MILD
Onset: EARLY
Inability To Sleep Incidence:
7.0%*
Severity: MILD
Onset: EARLY
Stomach Pain Incidence:
8.2%*
Severity: MILD
Onset: EARLY
Lightheadedness Incidence:
11.0-14.3%*
Severity: MILD
Onset: EARLY
Upset Stomach Incidence:
11.0-20.4%*
Severity: MILD
Onset: EARLY
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for Zelapar 1.25mg Orally Disintegrating Tablet

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Severe Lifestyle Interaction
Tyramine-containing foods and Zelapar 1.25mg Orally Disintegrating Tablet(Selegiline Hydrochloride)
Tyramine-containing foods and Monoamine oxidase inhibitors(Selegiline Hydrochloride)
Avoid foods and beverages containing tyramine while taking this medicine. The following foods can cause sudden blood pressure increases and should also be avoided: aged cheese; yeast extract; protein extract; soy sauce; fava bean or broad bean pods; smoked meats; pickled meats; smoked poultry; pickled poultry; smoked fish (lox, smoked salmon); pickled fish (pickled herring); fermented sausage (bologna, pepperoni, salami, summer sausage); bananas; avocados; any over-ripe fruit. Selegiline products have specific guidelines. Dietary and beverage restrictions should continue for at least 2 weeks after stopping this medicine.
Severe Lifestyle Interaction
Alcohol and Zelapar 1.25mg Orally Disintegrating Tablet(Selegiline Hydrochloride)
Alcohol and Monoamine oxidase inhibitors(Selegiline Hydrochloride)
Alcohol interactions with this medicine can be serious and may cause increased sedation, increased blood pressure ('hypertensive crisis') or other side effects. Ask your health care provider for a list of items to avoid. You must adhere to all dietary restrictions. Alcoholic beverages to avoid include beer; wine; sherry; hard liquor; or liqueurs. Dietary and beverage restrictions should continue for at least 2 weeks after stopping this medicine.
Severe Lifestyle Interaction
Caffeine-containing Foods/Beverages and Zelapar 1.25mg Orally Disintegrating Tablet(Selegiline Hydrochloride)
Caffeine-containing Foods/Beverages and Monoamine oxidase inhibitors(Selegiline Hydrochloride)
Do not take this medicine with caffeine-containing dietary supplements, medicines, foods or beverages without talking to your health care provider. Food, medicine, and dietary interactions can be serious. Rapid heartbeats or serious increases in blood pressure, known as "hypertensive crisis", may occur. Try to avoid or limit the intake of all items containing caffeine such as tea, coffee, chocolate, and cola. Do not take nonprescription medicines that contain Caffeine, like "stay awake" or weight loss products, including herbal diet aids. Caffeine restrictions should continue for at least 1 to 2 weeks after stopping this medicine.
Pregnancy & Lactation Information
FIRST Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

SECOND Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

THIRD Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

Lactation

Caution - Not enough information is available to rule out harm to infants when this drug is taken by nursing mothers.


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