Zemplar Solution For Injection 2Mcg Drug Medication Dosage Information
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Zemplar: Solution for injection (2mcg)

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What is this Medicine?

PARICALCITOL (par i KAL si trole) is a man made form of vitamin D. It is used in patients with chronic renal failure. It helps your body maintain the right amount of calcium and phosphorus for healthy bones and teeth.

In-Depth Information

Zemplar 2mcg/ml Solution for Injection

NDC: 000744637
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Hyperparathyroidism

Sometimes used for but not FDA approved for the following conditions:
Renal Osteodystrophy

Storage Information
Discard unused portion. Do not store for later use.
Store at 77 degrees F; excursions permitted to 59-86 degrees F
Zemplar 2mcg/ml Solution for Injection

Reported Side Effects for Zemplar 2mcg/ml Solution for Injection

Itching Incidence:
<2.8%*
Severity: MILD
Onset: RAPID
Fluid In Lungs Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Hives Incidence:
<2.0%*
Severity: MILD
Onset: RAPID
Dry Mouth Incidence:
<3.2%*
Severity: MILD
Onset: EARLY
Stomach Pain Incidence:
<3.7%*
Severity: MILD
Onset: EARLY
Difficulty Swallowing Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Infection Incidence:
<8.2%*
Severity: MILD
Onset: DELAYED
Fluid Retention Incidence:
<3.3%*
Severity: MODERATE
Onset: DELAYED
Fainting Incidence:
<2.8%*
Severity: MILD
Onset: EARLY
Secondary Malignancy Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Abnormal Heart Rhythm Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Weakness Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Low Colon Blood Flow Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Chest Pain Incidence:
<2.8%*
Severity: MODERATE
Onset: EARLY
Confusion Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Conjunctivitis Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Night Sweats Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Wheezing Incidence:
<2.0%*
Severity: MODERATE
Onset: RAPID
Weight Loss Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Restlessness Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Skin Rash Incidence:
<3.7%*
Severity: MILD
Onset: EARLY
Prolonged Bleeding Time Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Paresthesias Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Rapid Muscle Twitches Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Enlarged Lymph Nodes Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Injection Site Reaction Incidence:
<2.0%*
Severity: MILD
Onset: RAPID
Impotence (erectile Dysfunction) Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Hypoesthesia Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Engorgement With Blood Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Heartburn Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Metallic Taste Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Lightheadedness Incidence:
<6.6%*
Severity: MILD
Onset: EARLY
Hirsutism Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Headache Incidence:
<4.7%*
Severity: MILD
Onset: EARLY
Inflamed Stomach Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Tired Incidence:
<3.3%*
Severity: MILD
Onset: EARLY
Shortness Of Breath Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Loose Stools Incidence:
<11.5%*
Severity: MILD
Onset: EARLY
Delirium Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Cough Incidence:
<2.8%*
Severity: MILD
Onset: DELAYED
Constipation Incidence:
<4.9%*
Severity: MODERATE
Onset: DELAYED
Suddenly Stopped Heart Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Irregular Heart Rate Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Nervousness Incidence:
<3.3%*
Severity: MILD
Onset: DELAYED
Anemia Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Hair Loss Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Distressed Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Acne Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
High Calcium Levels Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Inability To Sleep Incidence:
<4.9%*
Severity: MILD
Onset: EARLY
High Potassium Level Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Low Blood Pressure Incidence:
<4.7%*
Severity: MODERATE
Onset: RAPID
Sore Throat Incidence:
<8.2%*
Severity: MILD
Onset: DELAYED
High Eye Blood Pressure Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
High Phosphate Levels Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Muscle Pain Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
High Blood Pressure Incidence:
<6.5%*
Severity: MODERATE
Onset: EARLY
Low Calcium Levels Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Dehydration Incidence:
2.8%*
Severity: MODERATE
Onset: DELAYED
Skin Ulcer Incidence:
2.8%*
Severity: MODERATE
Onset: DELAYED
Depression Incidence:
2.8%*
Severity: MODERATE
Onset: DELAYED
Muscle Cramps Incidence:
2.8%*
Severity: MILD
Onset: DELAYED
Sinus Infection Incidence:
2.8-3.3%*
Severity: MILD
Onset: DELAYED
Back Pain Incidence:
2.8%*
Severity: MILD
Onset: DELAYED
Feeling Sick Incidence:
3.2%*
Severity: MILD
Onset: EARLY
Rapid Heart Rate Incidence:
3.2%*
Severity: MODERATE
Onset: EARLY
Low Blood Sugar Incidence:
3.3%*
Severity: MODERATE
Onset: EARLY
Kidney Failure Incidence:
3.3%*
Severity: SEVERE
Onset: DELAYED
Vomiting Incidence:
4.7-8.1%*
Severity: MILD
Onset: EARLY
Joint Pain Incidence:
4.7%*
Severity: MILD
Onset: DELAYED
Balance Problems Incidence:
4.7%*
Severity: MILD
Onset: EARLY
Intestinal Bleeding Incidence:
4.8%*
Severity: SEVERE
Onset: DELAYED
Flu Incidence:
4.8%*
Severity: MILD
Onset: DELAYED
Fever Incidence:
4.8%*
Severity: MILD
Onset: EARLY
Chills Incidence:
4.8%*
Severity: MILD
Onset: RAPID
Swelling Incidence:
5.6%*
Severity: MODERATE
Onset: DELAYED
Upset Stomach Incidence:
5.6-12.9%*
Severity: MILD
Onset: EARLY
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for Zemplar 2mcg/ml Solution for Injection

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Moderate Lifestyle Interaction
Grapefruit juice and Zemplar 2mcg/ml Solution for Injection(Paricalcitol)
Grapefruit juice and Paricalcitol(Paricalcitol)
Grapefruit juice and grapefruit-containing foods may increase the side effects of Paricalcitol (Zemplar). Do not significantly increase grapefruit juice intake while taking this drug, or avoid grapefruit juice if possible. Side effects from Paricalcitol include dizziness, fatigue or sleepiness, loss of appetite, dry mouth or metallic taste, nausea or vomiting, stomach cramps, constipation or diarrhea, ringing in the ears, loss of balance, skin rash, muscle or joint pain, or general irritability. Report any unexplained or persistent side effects to your health care provider.
Pregnancy & Lactation Information
FIRST Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

SECOND Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

THIRD Trimester

Class C - Animal studies have shown an adverse effect and there are no adequate and well-controlled studies in pregnant women. OR No animal studies have been conducted and there are no adequate and well-controlled studies in pregnant women.

Lactation

Caution - Not enough information is available to rule out harm to infants when this drug is taken by nursing mothers.


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