Zonalon Topical Cream 5pct Drug Medication Dosage Information
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Zonalon: Topical cream (5%)

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Zonalon 5% Cream
Drug Image file default-drug-image.png
Zonalon 5% Cream

What is this Medicine?

DOXEPIN (DOX e pin) is used on the skin to treat itching caused by certain types of skin disorders.

Similar Brand Name Drugs : Prudoxin: Topical cream (5%)
CVS Pharmacy Patient Statistics for Zonalon: Topical cream(5%)
Generic vs. Brand Name Usage*
*Brand contains same active ingredient but may not represent FDA-approved generic equivalent
Usage By Strength
In-Depth Information
Select a Medication

Zonalon 5% Topical Cream

NDC: 103370804
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Lichen Simplex, Eczema, Atopic Dermatitis

Storage Information
Store below 80 degrees F
Zonalon 5% Topical Cream

Reported Side Effects for Zonalon 5% Topical Cream

Eosinophilia Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Elevated Hepatic Enzymes Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Dystonic Reaction Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Dyskinesia Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Metallic Taste Incidence:
<1.0%*
Severity: MILD
Onset: EARLY
Double Vision Incidence:
<0.1%*
Severity: MILD
Onset: EARLY
Chills Incidence:
<0.1%*
Severity: MILD
Onset: RAPID
Broken Bones Incidence:
<0.1%*
Severity: SEVERE
Onset: DELAYED
Weakness Incidence:
<1.0%*
Severity: MILD
Onset: DELAYED
Vomiting Incidence:
<1.0%*
Severity: MILD
Onset: EARLY
Fainting Incidence:
<1.0%*
Severity: MILD
Onset: EARLY
Convulsions Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Muscle Cramps Incidence:
<0.1%*
Severity: MILD
Onset: DELAYED
Low White Blood Cell Counts Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Yellow Skin Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Flu Incidence:
<0.1%*
Severity: MILD
Onset: DELAYED
Infection Incidence:
<1.0%*
Severity: MILD
Onset: DELAYED
ST-T Wave Changes Incidence:
<0.1%*
Severity: MODERATE
Onset: RAPID
Rapid Heart Rate Incidence:
<0.1%*
Severity: MODERATE
Onset: RAPID
Serotonin Syndrome Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Skin Rash Incidence:
<1.0%*
Severity: MILD
Onset: EARLY
Bruises Incidence:
<1.0%*
Severity: MILD
Onset: DELAYED
Pseudoparkinsonism Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Paresthesias Incidence:
<1.0%*
Severity: MILD
Onset: DELAYED
Rapid Heart Rate Incidence:
<0.1%*
Severity: MODERATE
Onset: EARLY
Heartburn Incidence:
<1.0%*
Severity: MILD
Onset: DELAYED
Bruise Incidence:
<0.1%*
Severity: MODERATE
Onset: EARLY
Liver Failure Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Nightmares Incidence:
<1.0%*
Severity: MILD
Onset: EARLY
Nighttime Urination Incidence:
<1.0%*
Severity: MILD
Onset: EARLY
Ear Pain Incidence:
<0.1%*
Severity: MILD
Onset: EARLY
Inability To Sleep Incidence:
<1.0%*
Severity: MILD
Onset: EARLY
Underactive Thyroid Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Low Potassium Levels Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
Overactive Thyroid Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
High Blood Pressure Incidence:
<3.0%*
Severity: MODERATE
Onset: EARLY
High Bilirubin Level Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
Enlarged Thyroid Gland Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Inflamed Hair Follicles Incidence:
<0.1%*
Severity: MILD
Onset: DELAYED
Swelling Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Painful Urination Incidence:
<1.0%*
Severity: MODERATE
Onset: EARLY
Shortness Of Breath Incidence:
<0.1%*
Severity: MODERATE
Onset: EARLY
Loose Stools Incidence:
<1.0%*
Severity: MILD
Onset: EARLY
Diabetes Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Cough Incidence:
<0.1%*
Severity: MILD
Onset: DELAYED
Eye Twitch Incidence:
<0.1%*
Severity: MODERATE
Onset: EARLY
Heart Block Incidence:
<0.1%*
Severity: SEVERE
Onset: EARLY
Decreased Appetite Incidence:
<1.0%*
Severity: MILD
Onset: DELAYED
Anemia Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Hair Loss Incidence:
<1.0%*
Severity: MILD
Onset: DELAYED
Runny Nose Incidence:
<0.1%*
Severity: MILD
Onset: EARLY
Itching Incidence:
<1.0%*
Severity: MILD
Onset: RAPID
Low Platelet Count Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Ringing In Ears Incidence:
<0.1%*
Severity: MILD
Onset: DELAYED
Dry Eyes Incidence:
<0.1%*
Severity: MILD
Onset: EARLY
Eye Pain Incidence:
<0.1%*
Severity: MILD
Onset: EARLY
Stomach Pain Incidence:
<1.0%*
Severity: MILD
Onset: EARLY
No White Blood Cells Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Liver Infection Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Joint Pain Incidence:
0.1-1.0%*
Severity: MILD
Onset: DELAYED
Pale Skin Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Wheezing Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: RAPID
Sinus Infection Incidence:
0.1-1.0%*
Severity: MILD
Onset: DELAYED
Inflamed Vocal Cords Incidence:
0.1-1.0%*
Severity: MILD
Onset: DELAYED
Muscle Pain Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Stuffy Nose Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Chest Pain Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: EARLY
Back Pain Incidence:
0.1-1.0%*
Severity: MILD
Onset: DELAYED
High Magnesium Level Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
High Potassium Level Incidence:
0.1-1.0%*
Severity: SEVERE
Onset: DELAYED
Upset Stomach Incidence:
1.0-10.0%*
Severity: MILD
Onset: EARLY
Dysarthria Incidence:
1.0-10.0%*
Severity: MODERATE
Onset: DELAYED
Yawning Incidence:
1.0-10.0%*
Severity: MILD
Onset: EARLY
Flushing Incidence:
1.0-10.0%*
Severity: MILD
Onset: RAPID
Allergic Skin Reaction Incidence:
1.0-10.0%*
Severity: MODERATE
Onset: DELAYED
Excessive Sweating Incidence:
1.0-10.0%*
Severity: MILD
Onset: DELAYED
Tired Incidence:
1.0-10.0%*
Severity: MILD
Onset: EARLY
Causing To Be Hungry Incidence:
1.0-10.0%*
Severity: MILD
Onset: DELAYED
Sore Throat Incidence:
2.0-4.0%*
Severity: MILD
Onset: DELAYED
Lightheadedness Incidence:
>10.0%*
Severity: MILD
Onset: EARLY
Tiredness Incidence:
>10.0%*
Severity: MILD
Onset: EARLY
Impotence (erectile Dysfunction) Incidence:
>10.0%*
Severity: MODERATE
Onset: DELAYED
Weight Gain Incidence:
>10.0%*
Severity: MILD
Onset: DELAYED
Upset Stomach Incidence:
>10.0%*
Severity: MILD
Onset: EARLY
Ejaculation Dysfunction Incidence:
>10.0%*
Severity: MODERATE
Onset: DELAYED
Dry Mouth Incidence:
>10.0%*
Severity: MILD
Onset: EARLY
Drowsiness Incidence:
>10.0%*
Severity: MILD
Onset: EARLY
Postural Low Blood Pressure Incidence:
>10.0%*
Severity: MODERATE
Onset: DELAYED
Constipation Incidence:
>10.0%*
Severity: MODERATE
Onset: DELAYED
Blurred Vision Incidence:
>10.0%*
Severity: MODERATE
Onset: EARLY
Retaining Urine Incidence:
>10.0%*
Severity: MODERATE
Onset: EARLY
Skin Irritation Incidence:
23.0%*
Severity: MILD
Onset: EARLY
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for Zonalon 5% Topical Cream

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Major Lifestyle Interaction
Alcohol and Zonalon 5% Topical Cream(Doxepin Hydrochloride)
Alcohol and CNS Depressants(Doxepin Hydrochloride)
Avoid alcohol-containing drinks while taking this medicine. Using this drug along with alcohol can lead to serious side effects. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery until you know how this drug affects you, and especially if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Major Lifestyle Interaction
Marijuana and Zonalon 5% Topical Cream(Doxepin Hydrochloride)
Marijuana and Tricyclic antidepressants(Doxepin Hydrochloride)
Do not take Marijuana, Medical and Tricyclic Antidepressants together without talking to your health care provider. Taking these drugs together might increase the risk of high blood pressure or heart rate, nervousness, palpitations, problems with sleep, severe headache, or other side effects.
Moderate Lifestyle Interaction
Tobacco and Zonalon 5% Topical Cream(Doxepin Hydrochloride)
Tobacco and Tricyclic antidepressants(Doxepin Hydrochloride)
Tobacco smoking may reduce the effectiveness of this drug in treating your condition. Tobacco smoke contains substances that speed the removal of this drug from the body, which in theory can make this drug less effective. Alternatively, if you take this drug and suddenly stop Tobacco smoking, you may experience drug-related side effects like confusion, constipation, dizziness, difficulty with urination, dry mouth and eyes or drowsiness. Make sure your prescriber is aware that you smoke Tobacco or if you plan to stop smoking.
Pregnancy & Lactation Information
FIRST Trimester

Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

SECOND Trimester

Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

THIRD Trimester

Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Lactation

Caution - Not enough information is available to rule out harm to infants when this drug is taken by nursing mothers.


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