Vomiting Incidence: 2.0-10.0%* Severity: MILD
Onset: EARLY

Upset Stomach Incidence: 2.0-10.0%* Severity: MILD
Onset: EARLY

Stomach Pain Incidence: 2.0-10.0%* Severity: MILD
Onset: EARLY

Heartburn Incidence: 2.0-10.0%* Severity: MILD
Onset: EARLY

Upset Stomach Incidence: 2.0-10.0%* Severity: MILD
Onset: EARLY

Alcohol and Acetaminophen(Acetaminophen)

Patients who drink more than 3 alcoholic drinks a day and take acetaminophen are at increased risk of developing liver side effects. Avoid alcoholic drinks if you are taking acetaminophen on a regular basis.

Alcohol and Salicylates(Aspirin)

Side effects from this drug may get worse if you drink alcohol-containing drinks. If you have persistent stomach upset, vomit blood or what looks like coffee grounds, or have black, tarry stools, contact your health care provider immediately. Avoid alcohol containing drinks while taking aspirin. Alcohol intake should be limited even with short term use of aspirin or related pain relievers.

Tobacco and Acetaminophen(Acetaminophen)

If you are a tobacco smoker, use of Acetaminophen can increase the risk of liver side effects. Immediately tell your doctor if you get severe abdominal pain, nausea, vomiting, or yellowing of the skin. Do not exceed 4 g acetaminophen/day in adults. Tell your doctor if Acetaminophen does not help your headache or other pain. Tobacco smoke may reduce the effectiveness of Acetaminophen.

Grapefruit juice and Caffeine(Caffeine)

Side effects from Caffeine may get worse if you take Grapefruit juice or other foods that contain significant amounts of Grapefruit. Too much Caffeine can cause effects like nausea, nervousness, or sleeplessness. Do not significantly alter your grapefruit juice intake while taking medicines containing caffeine.

Tobacco and Caffeine(Caffeine)

Tobacco smoke contains substances that may speed the removal of Caffeine from the body. If you start smoking Caffeine may become less effective. Tobacco smokers often drink several caffeinated beverages daily. Just the opposite occurs when someone stops smoking tobacco; if you stop smoking this may increase the amount of Caffeine in the blood and side effects from Caffeine may get worse. Too much Caffeine can cause nausea, nervousness, or sleeplessness, and occasionally other effects like tremor. If you stop smoking tobacco, you may need to lower your Caffeine intake.

Caffeine-containing Foods/Beverages and Caffeine(Caffeine)

While taking Caffeine products, limit the use of foods, beverages, herbs and other medicines that contain additional caffeine, like coffee, teas, colas, chocolate and some diet pills. Too much Caffeine can cause effects like nausea, nervousness, or sleeplessness. Some drug products for adults that contain caffeine have about as much caffeine as a cup of coffee.