Acetaminophen, Aspirin, Caffeine Oral Tablet 250-250-65Mg Drug Medication Dosage Information
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Acetaminophen, Aspirin, Caffeine: Oral tablet (250-250-65mg)

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Pain Reliever Plus Tab
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Migraine Relief Caplet
McKesson Corporation
Pill Identification: L 374 
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Headache Relief ES Tab

What is this Medicine?

ACETAMINOPHEN; ASPIRIN; CAFFEINE (a set a MEE noe fen; AS pir in; KAF een) is a pain reliever. It is used to treat mild aches and pains. This medicine may help with arthritis, colds, headache (including migraine), muscle aches, menstrual cramps, sinusitis, and toothache.

CVS Pharmacy Patient Statistics for Acetaminophen, Aspirin, Caffeine: Oral tablet(250-250-65mg)
Generic vs. Brand Name Usage*
*Brand contains same active ingredient but may not represent FDA-approved generic equivalent
Usage By Strength
In-Depth Information
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Pain Reliever Plus 250mg-250mg-65mg Tablet

NDC: 009045135
  • Over the Counter
    (Prescription Not Required)
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved

Storage Information
Store at 77 degrees F; excursions permitted to 59-86 degrees F
Pain Reliever Plus 250mg-250mg-65mg Tablet
Daily Life Interactions for Pain Reliever Plus 250mg-250mg-65mg Tablet

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Major Lifestyle Interaction
Alcohol and Pain Reliever Plus 250mg-250mg-65mg Tablet(Acetaminophen)
Alcohol and Acetaminophen(Acetaminophen)
Patients who drink more than 3 alcoholic drinks a day and take Acetaminophen are at increased risk of developing liver side effects. Limit alcohol intake while taking Acetaminophen. Avoid alcoholic drinks if you are taking Acetaminophen on a regular basis.
Major Lifestyle Interaction
Alcohol and Pain Reliever Plus 250mg-250mg-65mg Tablet(Aspirin)
Alcohol and Salicylates(Aspirin)
Side effects from this drug may get worse if you drink alcohol-containing drinks. If you have persistent stomach upset, vomit blood or what looks like coffee grounds, or have black, tarry stools, contact your health care provider immediately. Avoid alcohol containing drinks while taking aspirin. Alcohol intake should be limited even with short term use of aspirin or related pain relievers.
Moderate Lifestyle Interaction
Tobacco and Pain Reliever Plus 250mg-250mg-65mg Tablet(Acetaminophen)
Tobacco and Acetaminophen(Acetaminophen)
If you are a tobacco smoker, use of Acetaminophen can increase the risk of liver side effects. Immediately tell your doctor if you get severe abdominal pain, nausea, vomiting, or yellowing of the skin. Do not exceed 4 g acetaminophen/day in adults. Tell your doctor if Acetaminophen does not help your headache or other pain. Tobacco smoke may reduce the effectiveness of Acetaminophen.
Moderate Lifestyle Interaction
Tobacco and Pain Reliever Plus 250mg-250mg-65mg Tablet(Caffeine)
Tobacco and Caffeine(Caffeine)
Tobacco smoke contains substances that may speed the removal of Caffeine from the body. If you start smoking Caffeine may become less effective. Tobacco smokers often drink several caffeinated beverages daily. Just the opposite occurs when someone stops smoking tobacco; if you stop smoking this may increase the amount of Caffeine in the blood and side effects from Caffeine may get worse. Too much Caffeine can cause nausea, nervousness, or sleeplessness, and occasionally other effects like tremor. If you stop smoking tobacco, you may need to lower your Caffeine intake.
Moderate Lifestyle Interaction
Caffeine-containing Foods/Beverages and Pain Reliever Plus 250mg-250mg-65mg Tablet(Caffeine)
Caffeine-containing Foods/Beverages and Caffeine(Caffeine)
While taking Caffeine-containing medicines, limit the use of foods, beverages (examples: coffee, tea, colas), herbs (examples: guarana, green tea) and other products that contain additional caffeine, such as chocolate and some non-prescription medications or dietary supplements for headache, insomnia, or weight loss. Too much Caffeine can cause effects like nausea, nervousness, or sleeplessness. Some drug products for adults that contain caffeine have about as much caffeine as a cup of coffee.
Minor Lifestyle Interaction
Grapefruit juice and Pain Reliever Plus 250mg-250mg-65mg Tablet(Caffeine)
Grapefruit juice and Caffeine(Caffeine)
Do not significantly alter your grapefruit juice intake while taking medicines containing caffeine. Some reports suggest that intake of grapefruit juice can increase side effects from caffeine. Too much Caffeine can cause effects like nausea, tremor, nervousness, or sleeplessness. If these occur, consider ingesting less caffeine daily.
Pregnancy & Lactation Information

Caution - Not enough information is available to rule out harm to infants when this drug is taken by nursing mothers.

Learning More About
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  • Find other class related drugs
  • Find additional patient usage statistics
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