Exparel Suspension For Injection 13.3Mg Drug Medication Dosage Information
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EXPAREL: Suspension for injection (13.3mg)

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What is this Medicine?

BUPIVACAINE LIPOSOMAL (bue PIV a kane LIP oh som al) is an anesthetic. It causes loss of feeling in the skin or other tissues. It is used to prevent and to treat pain from some procedures.

In-Depth Information

EXPAREL 13.3mg/mL Suspension for Injection

NDC: 652500266
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Postsurgical Regional Analgesia, Postsurgical Local Analgesia

Storage Information
Do not autoclave
Avoid excessive heat (above 104 degrees F)
Discard unused portion. Do not store for later use.
Do not freeze
Discard if product has been frozen
Refrigerate (between 36 and 46 degrees F)
May be stored at controlled room temperature for up to 30 days in sealed, unopened vial
EXPAREL 13.3mg/mL Suspension for Injection

Reported Side Effects for EXPAREL 13.3mg/mL Suspension for Injection

Laryngeal Edema Incidence:
<1.0%*
Severity: SEVERE
Onset: RAPID
Ringing In Ears Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Shaking Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Uncontrolled Urination Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Retaining Urine Incidence:
<7.6%*
Severity: MODERATE
Onset: EARLY
Hives Incidence:
<2.0%*
Severity: MILD
Onset: RAPID
Rapid Heart Rate Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Bundle-branch Block Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Infection Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Vocal Cord Spasm Incidence:
<2.0%*
Severity: SEVERE
Onset: RAPID
Decreased Breathing Incidence:
<2.0%*
Severity: MODERATE
Onset: RAPID
Fainting Incidence:
<2.1%*
Severity: MILD
Onset: EARLY
Anaphylactoid Reactions Incidence:
<1.0%*
Severity: SEVERE
Onset: RAPID
Decreased Breathing Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Weakness Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Back Pain Incidence:
<10.0%*
Severity: MILD
Onset: DELAYED
Blurred Vision Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Confusion Incidence:
<5.0%*
Severity: MODERATE
Onset: EARLY
Injection Site Reaction Incidence:
<2.0%*
Severity: MILD
Onset: RAPID
Hypoxia Incidence:
<2.4%*
Severity: MODERATE
Onset: EARLY
Elevated Hepatic Enzymes Incidence:
<4.2%*
Severity: MODERATE
Onset: DELAYED
Skin Redness Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Bruise Incidence:
<2.4%*
Severity: MODERATE
Onset: EARLY
High Body Temperature Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Depression Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Distressed Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Angioedema Incidence:
<1.0%*
Severity: SEVERE
Onset: RAPID
Nervousness Incidence:
<3.0%*
Severity: MILD
Onset: DELAYED
Joint Pain Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Heart Block Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Weakness Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Suddenly Stopped Heart Incidence:
<2.0%*
Severity: SEVERE
Onset: EARLY
Blood Clot Incidence:
<2.0%*
Severity: SEVERE
Onset: DELAYED
Cough Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Delirium Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Drowsiness Incidence:
<5.2%*
Severity: MILD
Onset: EARLY
Restlessness Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Painful Urination Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Not Breathing Incidence:
<2.0%*
Severity: SEVERE
Onset: RAPID
Skin Rash Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Paresthesias Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Excessive Sweating Incidence:
<4.7%*
Severity: MILD
Onset: DELAYED
High Blood Pressure Incidence:
<5.0%*
Severity: MODERATE
Onset: EARLY
Rapid Heart Rate Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Pale Skin Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Muscle And/Or Bone Pain Incidence:
<2.0%*
Severity: MILD
Onset: EARLY
Postural Low Blood Pressure Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Irregular Heart Beat Incidence:
0.6-1.3%*
Severity: SEVERE
Onset: EARLY
Anemia Incidence:
1.2-9.9%*
Severity: MODERATE
Onset: DELAYED
Shortness Of Breath Incidence:
1.2-1.3%*
Severity: MODERATE
Onset: EARLY
Slow Heart Beat Incidence:
1.3-1.6%*
Severity: SEVERE
Onset: RAPID
Tiredness Incidence:
1.3%*
Severity: MILD
Onset: EARLY
Hiccups Incidence:
1.3-2.4%*
Severity: MILD
Onset: EARLY
Hypoesthesia Incidence:
1.5-3.6%*
Severity: MILD
Onset: DELAYED
Rapid Heart Rate Incidence:
1.8-3.9%*
Severity: MODERATE
Onset: RAPID
Low Blood Pressure Incidence:
2.0-9.9%*
Severity: MODERATE
Onset: RAPID
Fever Incidence:
2.0-23.3%*
Severity: MILD
Onset: EARLY
Inability To Sleep Incidence:
2.0-9.9%*
Severity: MILD
Onset: EARLY
Itching Incidence:
2.0-15.0%*
Severity: MILD
Onset: RAPID
Muscle Cramps Incidence:
2.0-9.9%*
Severity: MILD
Onset: DELAYED
Fluid Retention Incidence:
2.0-9.9%*
Severity: MODERATE
Onset: DELAYED
Lightheadedness Incidence:
2.0-11.3%*
Severity: MILD
Onset: EARLY
Vomiting Incidence:
2.1-27.8%*
Severity: MILD
Onset: EARLY
Constipation Incidence:
2.1-21.9%*
Severity: MODERATE
Onset: DELAYED
Upset Stomach Incidence:
2.1-40.2%*
Severity: MILD
Onset: EARLY
Decreased Appetite Incidence:
2.1%*
Severity: MILD
Onset: DELAYED
Low Potassium Levels Incidence:
3.0-4.2%*
Severity: MODERATE
Onset: DELAYED
Headache Incidence:
3.3-8.3%*
Severity: MILD
Onset: EARLY
Tired Incidence:
4.2-5.0%*
Severity: MILD
Onset: EARLY
Metallic Taste Incidence:
7.1-7.3%*
Severity: MILD
Onset: EARLY
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Pregnancy & Lactation Information
First Trimester

Class 3 - Risk Documented in Animals

Second Trimester

Class 3 - Risk Documented in Animals

Third Trimester

Class 3 - Risk Documented in Animals

Lactation

Caution - Not enough information is available to rule out harm to infants when this drug is taken by nursing mothers.


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