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Most Commonly Used

Methotrexate 50mg/2mL for Inj
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Methotrexate 2.5mg Tab
Hikma Pharmaceuticals USA Inc.
Pill Identification: 54 323 
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Methotrexate 50mg/2mL for Inj
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Methotrexate 2.5mg Tab
Mylan Pharmaceuticals Inc.
Pill Identification: M 14 
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Methotrexate 25mg/mL for Inj
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Also See:

  • Answers to Frequently-Asked Questions (FAQs)
  • Other Class Related Drugs
  • Additional Patient Usage Statistics

Common Side Effects of Methotrexate Sodium
Before you start taking methotrexate, tell your doctor if you have any allergies or medical conditions. Also let your doctor know about any medicines you are taking, including over-the-counter medicines, and any supplements. Some medicines interact with methotrexate and may raise the risk that you will develop serious side effects. Your doctor will want to make sure all your medicines are safe to take with methotrexate.

Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Methotrexate may cause birth defects or death to a growing fetus. Methotrexate is not recommended for breast-feeding mothers. Men and women should use effective methods of birth control while taking methotrexate. A man must continue using birth control methods for at least three months after he stops taking methotrexate. A woman must use birth control until after her first period after discontinuing methotrexate.

Methotrexate can cause side effects. Once you start taking methotrexate, let your doctor know if you experience the following side effects, particularly if they last a long time or are severe:
  • Sores in the mouth, or gums that are swollen or tender
  • Headaches
  • Nausea and upset stomach
  • Dizziness or drowsiness
  • Fatigue
  • Fever and chills
  • Loss of appetite
  • Loss of hair
Get immediate medical help if you experience the following symptoms while taking methotrexate:
  • Vision loss or blurred vision
  • Confusion, seizures, or loss of consciousness
  • Difficulty moving one or both sides of the body or weakness
If you are taking methotrexate, you should be aware of some of more serious side effects. Watch for signs of an allergic reaction to methotrexate. These signs include skin rash, itching, hives, or swelling of the face, lips, or tongue.

Methotrexate can cause low blood counts by decreasing the number of white blood cells, red blood cells, and platelets. Tell you doctor if you have signs of infection that include fever, chills, cough, sore throat, pain, or difficulty passing urine. It is important to tell your doctor if you have signs of decreased platelets or bleeding, which would include bruising; pinpoint red spots on the skin; black, tarry stools; or blood in the urine. Signs of decreased red blood cells include being unusually weak or tired, fainting spells, and light-headedness.

Methotrexate can cause other side effects. Contact your doctor if any side effect worsens, worries you, or will not go away. Ask your doctor or pharmacist right away about whether something you notice is a possible side effect of methotrexate. Your doctor will decide if methotrexate is right medicine to treat your condition.