Pioglitazone, Metformin Hydrochloride Oral Tablet 15-500Mg Drug Medication Dosage Information
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Pioglitazone, Metformin Hydrochloride: Oral tablet (15-500mg)

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Drug Image file DrugItem_26733.JPG
Pioglit/Metformin 15-500mg Tab
MacLeods Pharma
Pill Identification: C27 
Drug Image file DrugItem_25994.JPG
Pioglit/Metformin 15-500mg Tab
Aurobindo Pharma USA Inc.
Pill Identification: H  |  92
Drug Image file DrugItem_20953.JPG
Pioglit/Metformin 15-500mg Tab
Mylan Pharmaceuticals Inc.
Pill Identification: MYLAN  |  P155
Drug Image file DrugItem_18960.JPG
Pioglit/Metformin 15-500mg Tab
Torrent Pharma, Inc
Pill Identification: 1280  |  15/500
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Pioglit/Metformin 15-500mg Tab

What is this Medicine?

METFORMIN; PIOGLITAZONE (met FOR min; pye oh GLI ta zone) helps to treat type 2 diabetes. It helps to control blood sugar. Treatment is combined with diet and exercise.

CVS Pharmacy Patient Statistics for Pioglitazone, Metformin Hydrochloride: Oral tablet(15-500mg)
Generic vs. Brand Name Usage*
*Brand contains same active ingredient but may not represent FDA-approved generic equivalent
Usage By Strength
In-Depth Information
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Pioglitazone Hydrochloride and Metformin Hydrochloride 15mg-500mg Tablet

NDC: 333420176
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Type 2 Diabetes Mellitus

Storage Information
Avoid excessive humidity
Protect from moisture
Store between 68 to 77 degrees F, excursions permitted 59 to 86 degrees F
Pioglitazone Hydrochloride and Metformin Hydrochloride 15mg-500mg Tablet
Drug Image file DrugItem_26733.JPG
MacLeods Pharma
Pill Identification: C27 
Shape: oblong
Color: white

Reported Side Effects for Pioglitazone Hydrochloride and Metformin Hydrochloride 15mg-500mg Tablet

Megaloblastic Anemia Incidence:
<1.0%*
Severity: SEVERE
Onset: DELAYED
Irregular Periods Incidence:
<0.4%*
Severity: MILD
Onset: DELAYED
Electrolyte Imbalance Incidence:
<0.1%*
Severity: SEVERE
Onset: DELAYED
Electrolyte Imbalance Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
Low Blood Sugar Incidence:
<8.5%*
Severity: MODERATE
Onset: EARLY
Anemia Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Elevated Hepatic Enzymes Incidence:
0.3%*
Severity: MODERATE
Onset: DELAYED
Decreased Appetite Incidence:
1.0-10.0%*
Severity: MILD
Onset: DELAYED
Metallic Taste Incidence:
1.0-10.0%*
Severity: MILD
Onset: EARLY
Feeling Sick Incidence:
1.0-5.0%*
Severity: MILD
Onset: EARLY
Metallic Taste Incidence:
1.0-10.0%*
Severity: MILD
Onset: EARLY
Stomach Pain Incidence:
1.0-10.0%*
Severity: MILD
Onset: EARLY
Upset Stomach Incidence:
1.0-10.0%*
Severity: MILD
Onset: EARLY
Muscle Pain Incidence:
1.0-5.4%*
Severity: MILD
Onset: EARLY
Gas Incidence:
1.0-10.0%*
Severity: MILD
Onset: EARLY
Heart Failure Incidence:
1.1-5.7%*
Severity: SEVERE
Onset: DELAYED
Fluid Retention Incidence:
1.6-26.7%*
Severity: MODERATE
Onset: DELAYED
Weight Gain Incidence:
2.7-13.9%*
Severity: MILD
Onset: DELAYED
Swelling Incidence:
3.0-6.0%*
Severity: MODERATE
Onset: DELAYED
Fluid Retention Incidence:
3.0-6.0%*
Severity: MODERATE
Onset: DELAYED
Upset Stomach Incidence:
3.6-5.8%*
Severity: MILD
Onset: EARLY
Infection Incidence:
4.4-16.0%*
Severity: MILD
Onset: DELAYED
Sinus Infection Incidence:
4.4-5.0%*
Severity: MILD
Onset: DELAYED
Headache Incidence:
4.6-6.0%*
Severity: MILD
Onset: EARLY
Lightheadedness Incidence:
4.8-5.4%*
Severity: MILD
Onset: EARLY
Loose Stools Incidence:
4.8-5.8%*
Severity: MILD
Onset: EARLY
Sore Throat Incidence:
5.1%*
Severity: MILD
Onset: DELAYED
Broken Bones Incidence:
5.1%*
Severity: SEVERE
Onset: DELAYED
Lack Of Vitamin B12 Incidence:
7.0%*
Severity: MODERATE
Onset: DELAYED
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for Pioglitazone Hydrochloride and Metformin Hydrochloride 15mg-500mg Tablet

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Moderate Lifestyle Interaction
Alcohol and Pioglitazone Hydrochloride and Metformin Hydrochloride 15mg-500mg Tablet(Metformin Hydrochloride)
Alcohol and Metformin Hydrochloride(Metformin Hydrochloride)
Avoid or limit the use of alcohol with metformin, due to an increased risk for side effects. Avoid excessive use of alcohol in any form. Alcoholic beverages can increase the risk of low blood sugar, or can cause increased blood sugar due to the calories in these beverages. Limit alcohol containing medicines and beverages if you are a patient with diabetes. If you use a blood sugar monitoring device, check your blood sugar regularly. Learn the signs and symptoms of high or low blood sugar, and know how you should treat these if they occur. Contact your health care provider immediately if you experience extreme weakness, increasing drowsiness, or difficulty breathing (heavy breathing, shortness of breath) which are symptoms of the more serious side effects of Metformin.
Moderate Lifestyle Interaction
Alcohol and Pioglitazone Hydrochloride and Metformin Hydrochloride 15mg-500mg Tablet(Pioglitazone Hydrochloride)
Alcohol and Thiazolidinediones(Pioglitazone Hydrochloride)
It is best to limit the ingestion of alcohol during use of this medicine. Alcohol can increase the risk for severe or prolonged low blood sugar. If you do choose to drink alcohol, make sure you do not take it on an empty stomach. Frequently monitor your blood sugar. Know the signs and symptoms of low blood sugar and how to treat them. Do not drive or operate machinery, or perform other hazardous tasks while ingesting alcohol.
Minor Lifestyle Interaction
Tobacco and Pioglitazone Hydrochloride and Metformin Hydrochloride 15mg-500mg Tablet(Metformin Hydrochloride)
Tobacco and Metformin Hydrochloride(Metformin Hydrochloride)
If you use tobacco or are trying to quit tobacco use, you may need to monitor your blood sugar more frequently. Nicotine, a component of tobacco, can increase the blood sugar. Also, if you are trying to quit smoking, as your body adjusts to not smoking, your blood sugar levels may change; the actions of Antidiabetic Agents (medicines used to treat diabetes) may be increased and this could lead to low blood sugar. Know the symptoms of low or high blood sugar and report them if they occur. Monitor your blood sugar regularly.
Minor Lifestyle Interaction
Tobacco and Pioglitazone Hydrochloride and Metformin Hydrochloride 15mg-500mg Tablet(Pioglitazone Hydrochloride)
Tobacco and Thiazolidinediones(Pioglitazone Hydrochloride)
If you use tobacco or are trying to quit tobacco use, you may need to monitor your blood sugar more frequently. Nicotine, a component of tobacco, can increase the blood sugar. Also, if you are trying to quit smoking, as your body adjusts to not smoking, your blood sugar levels may change; the actions of Antidiabetic Agents (medicines used to treat diabetes) may be increased and this could lead to low blood sugar. Know the symptoms of low or high blood sugar and report them if they occur. Monitor your blood sugar regularly.
Pregnancy & Lactation Information
First Trimester

Class 3 - Risk Documented in Animals

Second Trimester

Class 3 - Risk Documented in Animals

Third Trimester

Class 3 - Risk Documented in Animals

Lactation

Caution - Not enough information is available to rule out harm to infants when this drug is taken by nursing mothers.


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