Trokendi Xr Oral Capsule, Extended Release 100Mg Drug Medication Dosage Information
show timeout overlay link

Your Session Is About to Expire

This online session is about to expire due to inactivity. Click Continue to return to page.

  • Weekly Ad

Trokendi XR: Oral capsule, extended release (100mg)

Detailed Information
Also see:
  • Get answers to Frequently Asked Questions (FAQs)
  • Find other class related drugs
  • Find additional patient usage statistics
Visit Drug Summary Page
Drug Image file default-drug-image.png
Trokendi XR 100mg Capsule
Drug Image file default-drug-image.png
Trokendi XR 100mg Capsule

What is this Medicine?

TOPIRAMATE (toe PYRE a mate) is used to treat seizures in adults or children with epilepsy. It is also used for the prevention of migraine headaches.

CVS Pharmacy Patient Statistics for Trokendi XR: Oral capsule, extended release(100mg)
Generic vs. Brand Name Usage*
*Brand contains same active ingredient but may not represent FDA-approved generic equivalent
Usage By Strength
In-Depth Information

Trokendi XR 100mg Capsule

NDC: 177720103
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Tonic-clonic Seizures, Lennox-Gastaut Syndrome, Partial Seizures

Sometimes used for but not FDA approved for the following conditions:
Myoclonic Seizures, Absence Seizures, Atonic Seizures

Storage Information
Protect from light
Protect from moisture
Store at 77 degrees F; excursions permitted to 59-86 degrees F
Trokendi XR 100mg Capsule
Close All Sections Show

Reported Side Effects for Trokendi XR 100mg Capsule

Close Show
Dysarthria Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Drug-induced Body Odor Incidence:
<1.0%*
Severity: MILD
Onset: DELAYED
Lightheadedness Incidence:
<14.0%*
Severity: MILD
Onset: EARLY
Confusion Incidence:
<4.0%*
Severity: MODERATE
Onset: EARLY
Weakness Incidence:
<6.0%*
Severity: MILD
Onset: DELAYED
Causing To Be Hungry Incidence:
<1.0%*
Severity: MILD
Onset: DELAYED
Secondary Malignancy Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Vomiting Incidence:
<3.0%*
Severity: MILD
Onset: EARLY
Vaginal Bleeding Incidence:
<3.0%*
Severity: MODERATE
Onset: DELAYED
High Red Blood Cells Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
High Sodium Levels Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
Blood In The Urine Incidence:
<2.0%*
Severity: MODERATE
Onset: DELAYED
Difficulty Swallowing Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Dry Skin Incidence:
<5.0%*
Severity: MILD
Onset: DELAYED
Balance Problems Incidence:
<3.0%*
Severity: MILD
Onset: EARLY
Ringing In Ears Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Low Platelet Count Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Decreased Memory Incidence:
<11.0%*
Severity: MODERATE
Onset: DELAYED
Upset Stomach Incidence:
<14.0%*
Severity: MILD
Onset: EARLY
Weight Gain Incidence:
<1.0%*
Severity: MILD
Onset: DELAYED
Bruises Incidence:
<8.0%*
Severity: MILD
Onset: DELAYED
Psychomotor Impairment Incidence:
<8.0%*
Severity: MILD
Onset: EARLY
Pancytopenia Incidence:
<0.1%*
Severity: SEVERE
Onset: DELAYED
Pale Skin Incidence:
<1.0%*
Severity: MILD
Onset: EARLY
Nighttime Urination Incidence:
<1.0%*
Severity: MILD
Onset: EARLY
Large Pupil Incidence:
<0.1%*
Severity: MILD
Onset: EARLY
High Lymphocytes Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
Increased Sexual Desire Incidence:
<0.1%*
Severity: MILD
Onset: DELAYED
Decreased Sexual Desire Incidence:
<3.0%*
Severity: MILD
Onset: DELAYED
Inflamed Vocal Cords Incidence:
<8.0%*
Severity: MILD
Onset: DELAYED
Uncontrolled Movements Incidence:
<4.0%*
Severity: MODERATE
Onset: DELAYED
Increased Urination Incidence:
<3.0%*
Severity: MILD
Onset: EARLY
Decreased Reflexes Incidence:
<2.0%*
Severity: MILD
Onset: DELAYED
Excessive Mucle Tone Incidence:
<3.0%*
Severity: MODERATE
Onset: DELAYED
Bruise Incidence:
<1.0%*
Severity: MODERATE
Onset: EARLY
Inflamed Tongue Incidence:
<1.0%*
Severity: MODERATE
Onset: EARLY
Gingival Hyperplasia Incidence:
<1.0%*
Severity: MODERATE
Onset: DELAYED
Flushing Incidence:
<5.0%*
Severity: MILD
Onset: RAPID
Fecal Incontinence Incidence:
<1.0%*
Severity: MODERATE
Onset: EARLY
Emotional Lability Incidence:
<8.0%*
Severity: MILD
Onset: EARLY
Ejaculation Dysfunction Incidence:
<3.0%*
Severity: MODERATE
Onset: DELAYED
Depression Incidence:
<9.0%*
Severity: MODERATE
Onset: DELAYED
Painful Urination Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Nose Bleed Incidence:
<8.0%*
Severity: MILD
Onset: DELAYED
Melasma Incidence:
<0.1%*
Severity: MILD
Onset: DELAYED
Mania Incidence:
<0.1%*
Severity: MODERATE
Onset: EARLY
Inflamed Iris (Eye) Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
Gas Incidence:
<1.0%*
Severity: MILD
Onset: EARLY
Inability To Sleep Incidence:
<9.0%*
Severity: MILD
Onset: EARLY
Low Phosphate Level Incidence:
<6.0%*
Severity: MODERATE
Onset: DELAYED
Inflamed Stomach Incidence:
<3.0%*
Severity: MODERATE
Onset: DELAYED
Gum Inflammation Incidence:
<1.0%*
Severity: MILD
Onset: DELAYED
Low Blood Sodium Levels Incidence:
<0.1%*
Severity: MODERATE
Onset: DELAYED
High Ammonia Levels Incidence:
<26.0%*
Severity: MODERATE
Onset: DELAYED
Excessive Sweating Incidence:
<1.0%*
Severity: MILD
Onset: DELAYED
Overactive Thyroid Incidence:
<8.0%*
Severity: MODERATE
Onset: DELAYED
Extra Saliva Production Incidence:
<6.0%*
Severity: MILD
Onset: EARLY
High Blood Pressure Incidence:
<2.0%*
Severity: MODERATE
Onset: EARLY
Nervousness Incidence:
<8.0%*
Severity: MILD
Onset: DELAYED
Slow Heart Beat Incidence:
<1.0%*
Severity: SEVERE
Onset: RAPID
Kidney Stones Incidence:
<3.0%*
Severity: MODERATE
Onset: DELAYED
Dehydration Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Blood Clot Incidence:
0.1-1.0%*
Severity: SEVERE
Onset: DELAYED
Fluid From Breast Incidence:
0.1-1.0%*
Severity: MILD
Onset: DELAYED
Scotomata Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Drooping Eyelids Incidence:
0.1-1.0%*
Severity: MILD
Onset: DELAYED
Chest Pain Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: EARLY
Hemorrhoids Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Photosensitivity Incidence:
0.1-1.0%*
Severity: MILD
Onset: DELAYED
Irritated Blood Vessels Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: RAPID
Peripheral Vasodilation Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: RAPID
Dyskinesia Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Parosmia Incidence:
0.1-1.0%*
Severity: MILD
Onset: DELAYED
Hoarseness Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Dystonic Reaction Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Paranoia Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Delirium Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: EARLY
EEG Changes Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Eosinophilia Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Elated Mood Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: EARLY
Heart Block Incidence:
0.1-1.0%*
Severity: SEVERE
Onset: EARLY
Throat Inflammation Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Diabetes Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Melena Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Low Lymphocytes Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Enlarged Lymph Nodes Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Hyperesthesia Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Mouth Ulcers Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
High Platelet Count Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Retaining Urine Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: EARLY
Hives Incidence:
0.1-1.0%*
Severity: MILD
Onset: RAPID
Blood Clot In Lung Incidence:
0.1-1.0%*
Severity: SEVERE
Onset: DELAYED
Dry Eyes Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Light Sensitivity Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: EARLY
Decreased Urination Incidence:
0.1-1.0%*
Severity: SEVERE
Onset: EARLY
Increased Blood Sugar Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Increased Blood Fats Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Postural Low Blood Pressure Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Low Blood Pressure Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: RAPID
Nerve Pain Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Inceased Urination Incidence:
0.1-1.0%*
Severity: MILD
Onset: EARLY
Arthropathy Incidence:
0.1-1.0%*
Severity: MILD
Onset: DELAYED
Low Calcium Levels Incidence:
0.1-1.0%*
Severity: MODERATE
Onset: DELAYED
Bleeding Incidence:
0.2-4.5%*
Severity: MODERATE
Onset: EARLY
Skin Rash Incidence:
1.0-4.0%*
Severity: MILD
Onset: EARLY
Anemia Incidence:
1.0-3.0%*
Severity: MODERATE
Onset: DELAYED
Breathing Difficulties Incidence:
>1.0%*
Severity: SEVERE
Onset: RAPID
Dry Mouth Incidence:
1.0-5.0%*
Severity: MILD
Onset: EARLY
Impotence (erectile Dysfunction) Incidence:
>1.0%*
Severity: MODERATE
Onset: DELAYED
Muscle Pain Incidence:
>1.0%*
Severity: MILD
Onset: EARLY
Acute Cerebellar Syndrome Incidence:
>1.0%*
Severity: SEVERE
Onset: EARLY
Excessive Thirst Incidence:
1.0-2.0%*
Severity: MILD
Onset: EARLY
Secretion Of Tears Incidence:
1.0%*
Severity: MILD
Onset: EARLY
Bladder Infection Incidence:
1.0-3.0%*
Severity: MODERATE
Onset: DELAYED
Itching Incidence:
1.0-4.0%*
Severity: MILD
Onset: RAPID
Visual Impairment Incidence:
1.0-3.0%*
Severity: SEVERE
Onset: EARLY
Constipation Incidence:
>1.0%*
Severity: MODERATE
Onset: DELAYED
Hair Loss Incidence:
1.0-4.0%*
Severity: MILD
Onset: DELAYED
Yeast Infection Incidence:
>1.0%*
Severity: MODERATE
Onset: DELAYED
Distressed Incidence:
1.0-2.0%*
Severity: MILD
Onset: EARLY
Uncontrolled Urination Incidence:
1.0-4.0%*
Severity: MODERATE
Onset: EARLY
Heavy Menstrual Period Incidence:
1.0-2.0%*
Severity: MILD
Onset: DELAYED
Shaking Incidence:
>1.0%*
Severity: MILD
Onset: EARLY
Sinus Infection Incidence:
1.0-10.0%*
Severity: MILD
Onset: DELAYED
Joint Pain Incidence:
1.0-7.0%*
Severity: MILD
Onset: DELAYED
Eye Pain Incidence:
>1.0%*
Severity: MILD
Onset: EARLY
Convulsions Incidence:
1.0%*
Severity: SEVERE
Onset: DELAYED
Psychosis Incidence:
>1.0%*
Severity: MODERATE
Onset: EARLY
Headache Incidence:
>1.0%*
Severity: MILD
Onset: EARLY
Fainting Incidence:
>1.0%*
Severity: MILD
Onset: EARLY
Hot Flashes Incidence:
1.0-2.0%*
Severity: MODERATE
Onset: EARLY
Conjunctivitis Incidence:
>1.0%*
Severity: MODERATE
Onset: DELAYED
Irregular Periods Incidence:
>1.0%*
Severity: MILD
Onset: DELAYED
Fever Incidence:
1.0-12.0%*
Severity: MILD
Onset: EARLY
Skin Discoloration Incidence:
1.0%*
Severity: MILD
Onset: DELAYED
Low White Blood Cell Counts Incidence:
1.0-2.0%*
Severity: MODERATE
Onset: DELAYED
Infection Incidence:
1.0-15.0%*
Severity: MILD
Onset: DELAYED
Low Blood Sugar Incidence:
1.0%*
Severity: MODERATE
Onset: EARLY
Chest Pain Incidence:
>1.0%*
Severity: MODERATE
Onset: EARLY
Heartburn Incidence:
>1.0%*
Severity: MILD
Onset: DELAYED
Electrolyte Imbalance Incidence:
1.0-32.0%*
Severity: MODERATE
Onset: DELAYED
Swelling Incidence:
1.0-2.0%*
Severity: MODERATE
Onset: DELAYED
Migraine Incidence:
>1.0%*
Severity: MODERATE
Onset: EARLY
Hallucinations Incidence:
>1.0%*
Severity: MODERATE
Onset: EARLY
Deafness Incidence:
1.0-2.0%*
Severity: SEVERE
Onset: DELAYED
Shortness Of Breath Incidence:
1.0-3.0%*
Severity: MODERATE
Onset: EARLY
Dandruff Incidence:
1.0%*
Severity: MILD
Onset: DELAYED
Rhinitis Incidence:
1.0-5.0%*
Severity: MILD
Onset: EARLY
Sore Throat Incidence:
2.0-6.0%*
Severity: MILD
Onset: DELAYED
No Menstrual Periods Incidence:
2.0%*
Severity: MILD
Onset: DELAYED
Acne Incidence:
2.0-3.0%*
Severity: MILD
Onset: DELAYED
Unable To Speak Incidence:
2.0%*
Severity: MODERATE
Onset: DELAYED
Blurred Vision Incidence:
2.0-4.0%*
Severity: MODERATE
Onset: EARLY
Metallic Taste Incidence:
2.0-15.0%*
Severity: MILD
Onset: EARLY
Muscle Cramps Incidence:
2.0%*
Severity: MILD
Onset: DELAYED
Drowsiness Incidence:
2.0-15.0%*
Severity: MILD
Onset: EARLY
Loose Stools Incidence:
2.0-9.0%*
Severity: MILD
Onset: EARLY
Ambras Syndrome Incidence:
2.0%*
Severity: MILD
Onset: DELAYED
Irritability Incidence:
2.0%*
Severity: MILD
Onset: DELAYED
Vaginal Discharge Incidence:
2.0%*
Severity: MILD
Onset: DELAYED
Cough Incidence:
2.0-7.0%*
Severity: MILD
Onset: DELAYED
Paresthesias Incidence:
2.0-51.0%*
Severity: MILD
Onset: DELAYED
Upset Stomach Incidence:
3.0-5.0%*
Severity: MILD
Onset: EARLY
Back Pain Incidence:
3.0-5.0%*
Severity: MILD
Onset: DELAYED
Incoordination Incidence:
3.0-4.0%*
Severity: MODERATE
Onset: DELAYED
Hypoesthesia Incidence:
4.0-8.0%*
Severity: MILD
Onset: DELAYED
Decreased Appetite Incidence:
4.0-15.0%*
Severity: MILD
Onset: DELAYED
Hyperkinesis Incidence:
5.0%*
Severity: MILD
Onset: DELAYED
Stomach Pain Incidence:
6.0-15.0%*
Severity: MILD
Onset: EARLY
Weight Loss Incidence:
6.0-17.0%*
Severity: MILD
Onset: DELAYED
Tired Incidence:
7.0-19.0%*
Severity: MILD
Onset: EARLY
Fast Eye Movements Incidence:
10.0-11.0%*
Severity: MODERATE
Onset: DELAYED
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Daily Life Interactions for Trokendi XR 100mg Capsule
Close Show

Elements of your daily lifestyle may have an effect on the medications you are taking. Drug interactions can result in unwanted side effects, reduce the effectiveness of your medicine or possibly increase the action of a particular medicine.

Major Lifestyle Interaction
Alcohol and Trokendi XR 100mg Capsule(Topiramate)
Close Show
Alcohol and Topiramate(Topiramate)
Do not drink alcoholic beverages for 6 hours before or after taking Topiramate extended-release capsules. You should avoid alcoholic beverages while taking other forms of Topiramate. Alcohol can affect seizure control and interfere with the drug treatment, and may increase the risk of serious side effects. Decreased alertness, drowsiness, falls, or other side effects may occur. Do not drive or operate machinery if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.
Moderate Lifestyle Interaction
Marijuana and Trokendi XR 100mg Capsule(Topiramate)
Close Show
Marijuana and Topiramate(Topiramate)
Topiramate can theoretically increase the elimination of Marijuana, Medical from the body. The side effects profile of Marijuana, Medical may be altered if you take Topiramate. You may feel drowsy or more tired. Do not drive or operate machinery until you know how these drugs affect you. Contact your health care provider immediately if you notice slurred speech, confusion, increases heart rate, or palpitations while taking Marijuana, Medical.
Pregnancy & Lactation Information
Close Show
FIRST Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

SECOND Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

THIRD Trimester

Class D - Adequate well-controlled or observational studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective.

Lactation

Caution - Not enough information is available to rule out harm to infants when this drug is taken by nursing mothers.


Learning More About
Visit the Drug Summary page where you can:
  • Get answers to Frequently Asked Questions (FAQs)
  • Find other class related drugs
  • Find additional patient usage statistics
Learn More
Patient Experiences with Trokendi XR

Close Show

We want to help you stay educated about the medications you are taking. View other
patient's observations and share your own.

Be sure to consult your health care provider before taking any medications. Other
patient's comments should not be considered medical advice or health care provider
recommendations.