Xgeva Solution For Injection 70Mg Drug Medication Dosage Information
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XGEVA: Solution for injection (70mg)

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What is this Medicine?

DENOSUMAB (den oh sue mab) slows bone breakdown. Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more. Xgeva is used to treat a high calcium level due to cancer and to prevent bone fractures and other bone problems caused by multiple myeloma or cancer bone metastases. Xgeva is also used to treat giant cell tumor of the bone.

Similar Brand Name Drugs : Prolia: Solution for injection (60mg)
In-Depth Information

XGEVA 120mg/1.7mL Solution for Injection

NDC: 555130730
  • Prescription Required
  • Not a Controlled Drug
    (CSA Schedule)
  • FDA Approved




FDA approved for the following conditions:
Osteoporosis, Osteoporosis Prophylaxis, Bone Metastases, Giant Cell Tumor Of Bone, Multiple Myeloma, Hypercalcemia

Storage Information
Protect from extreme heat
Do not expose product to temperatures above 77 degrees F
Discard within 14 days after first use
Protect from light
Store in original container
Do not freeze
Product must be used within 14 days after removal from refrigeration to room temperature (77 degrees F)
Store unopened containers in refrigerator (36 to 46 degrees F)
Protect from direct sunlight
Discard product if it contains particulate matter, is cloudy, or discolored
XGEVA 120mg/1.7mL Solution for Injection

Reported Side Effects for XGEVA 120mg/1.7mL Solution for Injection

Balance Problems Incidence:
<5.0%*
Severity: MILD
Onset: EARLY
Fluid Retention Incidence:
<24.0%*
Severity: MODERATE
Onset: DELAYED
Vomiting Incidence:
<24.0%*
Severity: MILD
Onset: EARLY
Low Phosphate Level Incidence:
<15.4%*
Severity: SEVERE
Onset: DELAYED
Low Magnesium Levels Incidence:
<3.0%*
Severity: SEVERE
Onset: DELAYED
Low Calcium Levels Incidence:
<3.1%*
Severity: SEVERE
Onset: DELAYED
Tired Incidence:
<3.0%*
Severity: SEVERE
Onset: EARLY
Constipation Incidence:
<21.0%*
Severity: MODERATE
Onset: DELAYED
Irregular Heart Beat Incidence:
<1.0%*
Severity: SEVERE
Onset: EARLY
Decreased Appetite Incidence:
<24.0%*
Severity: MILD
Onset: DELAYED
Inflamed Pancreas Incidence:
0.2%*
Severity: SEVERE
Onset: DELAYED
Dead Bone Incidence:
0.7-7.1%*
Severity: SEVERE
Onset: DELAYED
Heartburn Incidence:
2.1%*
Severity: MILD
Onset: DELAYED
Joint Pain Incidence:
2.1-10.4%*
Severity: MILD
Onset: DELAYED
Itching Incidence:
2.2%*
Severity: MILD
Onset: RAPID
Gas Incidence:
2.2%*
Severity: MILD
Onset: EARLY
Weakness Incidence:
2.3-45.0%*
Severity: MILD
Onset: DELAYED
Sore Throat Incidence:
2.3%*
Severity: MILD
Onset: DELAYED
Skin Rash Incidence:
2.5%*
Severity: MILD
Onset: EARLY
Muscle Pain Incidence:
2.9-10.4%*
Severity: MILD
Onset: EARLY
Chest Pain Incidence:
>3.0%*
Severity: MODERATE
Onset: EARLY
Stomach Pain Incidence:
3.3%*
Severity: MILD
Onset: EARLY
Bone Pain Incidence:
3.7-19.0%*
Severity: MODERATE
Onset: DELAYED
Anemia Incidence:
4.0-21.0%*
Severity: MODERATE
Onset: DELAYED
Infection Incidence:
4.0-6.0%*
Severity: SEVERE
Onset: DELAYED
Nerve Pain Incidence:
4.6%*
Severity: MODERATE
Onset: DELAYED
Bladder Infection Incidence:
5.9%*
Severity: MODERATE
Onset: DELAYED
Muscle And/Or Bone Pain Incidence:
7.6%*
Severity: MILD
Onset: EARLY
Low White Blood Cells Incidence:
8.5%*
Severity: MODERATE
Onset: DELAYED
Back Pain Incidence:
10.0-34.7%*
Severity: MILD
Onset: DELAYED
Headache Incidence:
10.0-24.0%*
Severity: MILD
Onset: EARLY
Upset Stomach Incidence:
10.0-31.0%*
Severity: MILD
Onset: EARLY
Chills Incidence:
10.4%*
Severity: MILD
Onset: RAPID
Flushing Incidence:
10.4%*
Severity: MILD
Onset: RAPID
Fever Incidence:
10.4%*
Severity: MILD
Onset: EARLY
Cough Incidence:
>15.0%*
Severity: MILD
Onset: DELAYED
Loose Stools Incidence:
20.0-21.0%*
Severity: MILD
Onset: EARLY
Shortness Of Breath Incidence:
21.0-27.0%*
Severity: MODERATE
Onset: EARLY
*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different.
Pregnancy & Lactation Information
First Trimester

Class 3 - Risk Documented in Animals

Second Trimester

Class 3 - Risk Documented in Animals

Third Trimester

Class 3 - Risk Documented in Animals

Lactation

Avoid - This drug is known to cause harm to infants when taken by nursing mothers.


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