STORE OPEN Until 10:00 PM
PHARMACY OPEN Closing at 8:00 PM

CVS Pharmacy at 1300 Madonna Road San Luis Obispo, CA 93405

  • attention important covid-19 updateWe are reserving Wednesdays, 9AM-10AM exclusively for vulnerable guests & their caregivers.
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Store & Photo Hours

  • Thanksgiving Hours 8:00 AM to 10:00 PM
  • M-F 8:00 AM - 10:00 PM
  • Sat 8:00 AM - 10:00 PM
  • Sun 8:00 AM - 10:00 PM

Pharmacy Hours

  • Thanksgiving Hours 9:00 AM to 2:00 PM
  • M-F 9:00 AM - 8:00 PM
  • Sat 9:00 AM - 6:00 PM
  • Sun 10:00 AM - 6:00 PM

What services does this CVS offer?

About this Pharmacy & Drug Store


Between filling prescriptions from your doctor and keeping track of vitamins, supplements and vaccines, it can feel like staying healthy is a full-time job. Fortunately, CVS Pharmacy® is here to help. Our store at 1300 Madonna Road in San Luis Obispo offers fast prescription service, OTC medicine and flu shots to help you stay on track.


Convenient pharmacy location in San Luis Obispo


Our pharmacy at 1300 Madonna Road is easy to find: It's just west of I-101 near the intersection of Madonna Road and Boranda Street. Nearby landmarks, including Laguna Lake Park and Laguna Lake Municipal Golf Course make it easy for visitors and residents to find our store. You can come by any day of the week to enjoy fast and accurate prescription service.


Want to make your trip to CVS Pharmacy® even more productive? You can get your flu shot and other vaccines at our convenient walk-in clinic without an appointment. Our certified immunizing pharmacists provide CDC-recommended vaccines, including chicken pox and MMR, to teens, adults and seniors. If you prefer, you can get your flu shot at one of our off-site Flu Clinics. CVS Pharmacy® hosts these clinics at local businesses and community centers throughout the year.


Easy prescription order management online or with our app


Do you want to use your computer, phone or tablet to access your pharmacy account? Just create a personal CVS account, and download our mobile prescription services app. With just a few clicks or taps, you can manage automatic refills, transfer prescriptions, scan in new scripts and view your current orders. Our website is also full of helpful information, including details on drug interactions and our Pill Identifier tool. 


You can also save more on your trips to CVS Pharmacy®. Use the app to browse the current deals in our weekly ad, and link your ExtraCare® rewards card to your phone to increase your savings by up to three times more.


High-quality custom photo printing


The CVS Pharmacy® photo center offers quick photo printing service, making it easy for you to turn your digital pictures into priceless heirlooms. Once you upload your files, you can choose from numerous options, including:


  • Memory books
  • Calendars
  • Enlargements
  • Wallet photos
  • Personalized gifts


Some items are available for same-day pickup. The expert technicians at our photo center can also take your passport photo, so you can get started preparing for your next international trip.


Cosmetics, gifts and affordable essentials


While you're here at our store in San Luis Obispo to pick up your prescriptions, you can also stock up on other items for your home. Find cleaning products, baby supplies and seasonal gifts along with personal-care items, cosmetics, and OTC medicine, all at affordable prices.


You can also pick up pantry staples including snacks, treats and drinks. If you're a SNAP participant, you can pay for eligible items with your EBT card at our Madonna Road store.


Find what you need at our drug store


With CVS Pharmacy®, it's easy to take care of your health-care needs, including prescription and OTC medicine, vitamins and healthy foods. Our caring pharmacists can also give you information on special products including Plan B pills. To hear our store hours, call 805-549-0993.