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CVS® now offers FREE in-store pickup!

Currently available at select stores.

351 S. Main St. Wilkes Barre, PA 18701

Store #1591 Get directions
Set as myCVS store 570 825-3215

Closed 1:30-2 daily for lunch

Services at this store

COVID-19 Vaccines

Get vaccinated for COVID-19 today. Schedule your vaccine ahead of time so you can get out faster.

CVS Photo

At CVS Photo, you can turn your photos into gifts and pieces of art that will be cherished for years to come.

About this pharmacy & drug store

South Main Street CVS Pharmacy

The CVS Pharmacy at 351 South Main Street is a Wilkes Barre pharmacy that provides easy access to quick snacks and household supplies. The South Main Street store is your go-to for groceries, cosmetics, first aid supplies, and vitamins. Its easy-to-access location makes this Wilkes Barre pharmacy a neighborhood favorite.

It's great to find all the healthcare and household goods you need at just one location, but it's equally beneficial to get what you're looking for at affordable prices. The Wilkes Barre CVS Pharmacy is the place to go for great prices on the products you use often. Want even more perks? Get an ExtraCare® Membership and earn ExtraCare® Rewards on select items. You'll also be added to our email list and receive special offers, personalized coupons, and sales notifications.

Saving at the Neighborhood Wilkes Barre CVS Pharmacy

South Main Street CVS Pharmacy has become an accepted member of the Wilkes Barre area. We have become a useful source of day-to-day items that locals can find and purchase at their convenience. The drive-thru pharmacy at the Wilkes Barre CVS Pharmacy makes it possible to pick up your meds without having to find a parking space.

Shop for goods like personal care items, vitamins, cosmetics, and many other products in an easy-to-navigate store that will get your shopping done quickly and easily. Stocking up on essentials just got a lot easier.

Getting to South Main Street CVS Pharmacy

This CVS Pharmacy is a convenient place to get groceries, prescription medicine, and more in Wilkes Barre. Pick up everything you'll need for the week without leaving the comfortable confines of your immediate area. The S Main St and Academy St O transit station is just up the street from the South Main Street CVS Pharmacy, so even if you can't get a ride you can still get what you need. All you have to do is get on and off to shop, and get back on to get back home.

South Main Street CVS Pharmacy FAQ

Does South Main Street CVS Pharmacy have UPS drop-off?

No, UPS package drop-off in Wilkes Barre is not available at South Main Street CVS Pharmacy, but Market Street CVS Pharmacy located about 1 miles away is a UPS access point.

How much is a flu shot at CVS?

Flu shots in Wilkes Barre are free at CVS through Medicare Part B and to those with medical insurance. For customers without medical insurance or Medicare, it costs $73.99 for a senior dose vaccine, or $40.99 - $73.99 for a seasonal vaccine. South Main Street CVS Pharmacy administers flu shots to help you get through the season.

Does CVS accept EBT?

Yes, the South Main Street CVS Pharmacy takes the SNAP EBT card. Use your Wilkes Barre SNAP EBT card at this store to purchase food.

Does South Main Street CVS Pharmacy develop photos?

Yes, the South Main Street CVS Pharmacy is the place to go to get your photos developed in Wilkes Barre. This location develops all types of film, disposable cameras, and negatives on high-quality photo paper. Developing 35mm film or a disposable camera takes between 7 and 10 days, and processing APS, black and white film, slides, or 110 film takes about 3 weeks.

Does CVS at 351 S. Main St. Wilkes Barre, PA 18701 offer flu shots?

Flu shots are offered at the CVS Pharmacy at 351 S. Main St. Wilkes Barre, PA 18701.

Schedule your flu shot ahead of time so you can get in and out faster. Provide your insurance information and answer questions online ahead of time. Shop cold and flu and stay prepared this cold and flu season with immunity support products and more.