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CVS® now offers FREE in-store pickup!

Currently available at select stores.

315 Main St. Trussville, AL 35173

Store #4891 Get directions
Set as myCVS store 205 655-8804

Closed 1:30-2 daily for lunch

Services at this store

COVID-19 Vaccines

Get vaccinated for COVID-19 today. Schedule your vaccine ahead of time so you can get out faster.

CVS Photo

At CVS Photo, you can turn your photos into gifts and pieces of art that will be cherished for years to come.

About this pharmacy & drug store

Main Street CVS Pharmacy

The CVS Pharmacy at 315 Main Street is a Trussville pharmacy that provides easy access to quick pick-me-ups and household supplies. The Main Street location is your one-stop shop for cosmetics, groceries, vitamins, and first aid supplies. Its easy-to-access location has made this Trussville pharmacy a neighborhood fixture.

In addition to an incredible supply of healthcare, food, and more necessities, the neighborhood Trussville CVS Pharmacy is where customers can experience great discounts. Register for an ExtraCareÆ Membership to receive individualized coupons, notifications of sales, member email offers, and to start accumulating ExtraCareÆ Rewards on select items.

Saving at Your Nearby Trussville CVS Pharmacy

Main Street CVS Pharmacy is a proud part of the Trussville city. We're ready to aid each and every local searching for a place where they can purchase daily essentials quickly and easily. This Trussville CVS Pharmacy has a drive-thru pharmacy to meet your prescription refill needs without having to leave your car.

You can find vitamins, cosmetics, personal care items, and more in an easy-to-navigate store that will let you get on your way before you know it. Buying the everyday items you need couldn't be easier.

Getting to Main Street CVS Pharmacy

This CVS Pharmacy is the place to go to get prescription medicine and groceries in Trussville. Buy all your necessary supplies for the week without setting foot outside your immediate area. This CVS Pharmacy makes finding your everyday necessities easy, with prices that can't be beat.

Main Street CVS Pharmacy FAQ

Is Main Street CVS Pharmacy a UPS Access Point?

Yes, UPS drop-off and pickup in Trussville is available at this CVS Pharmacy. You can drop off prepaid and labeled packages for UPS to pick up for delivery within 24 hours. We can also hold packages mailed to you for as long as seven days.

How much is a flu shot at CVS?

Free flu shots in Trussville are available to those with health insurance and through Medicare Part B. For customers without Medicare or medical insurance, you'll pay $73.99 for a senior dose vaccine, or $40.99 - $73.99 for a seasonal vaccine. Main Street CVS Pharmacy administers flu shots to help you get through the season.

Does CVS take EBT?

Yes, the Main Street CVS Pharmacy accepts EBT. Use your Trussville SNAP EBT card at this location to buy food.

Does Main Street CVS Pharmacy do photo developing?

Yes, get your photos developed in Trussville at the Main Street CVS Pharmacy. We develop all types of film, disposable cameras, and negatives on high-quality photo paper. Processing 35mm film or a disposable camera takes between 7 and 10 days, and processing slides, 110 film, black and white film, or APS takes around 3 weeks.

Does CVS at 315 Main St. Trussville, AL 35173 test for coronavirus (COVID-19)?

CVS Health is conducting lab coronavirus testing (COVID-19) at 315 Main St. Trussville, AL. Patients are required to schedule an appointment for covid testing in advance. Limited appointments are available to qualifying patients due to high demand. Test types vary by location and will be confirmed during the scheduling process. Patients must bring their insurance card and proof of identity*. Please view our other coronavirus support options for more information. Also, find at-home COVID tests for sale online and in-store.